supported by grants from the Lone Star Paralysis Foundation,NIH R01NS081063;Department of Defense award W81XWH-19-2-0054 to GDB;supported by University of Wyoming Startup funds,Department of Defense grant W81XWH-17-1-0402;the University of Wyoming Sensory Biology COBRE under National Institutes of Health(NIH)award number 5P20GM121310-02;the National Institute of General Medical Sciences of the NIH under award number P20GM103432 to JSB。
Behavioral recovery using(viable)peripheral nerve allografts to repair ablation-type(segmental-loss)peripheral nerve injuries is delayed or poor due to slow and inaccurate axonal regeneration.Furthermore,such peripher...
supported by the National Natural Science Foundation of China, No.31972725(to WHY)
Previous studies showed that acetyl-11-keto-beta-boswellic acid(AKBA),the active ingredient in the natural Chinese medicine Boswellia,can stimulate sciatic nerve injury repair via promoting Schwann cell proliferation....
BACKGROUND A large ganglionic cyst extending from the hip joint to the intrapelvic cavity through the sciatic notch is a rare space-occupying lesion associated with compressive lower-extremity neuropathy.A cyst in the...
Regional anesthesia is an integral component of successful orthopedic surgery.Neuraxial anesthesia is commonly used for surgical anesthesia while peripheral nerve blocks are often used for postoperative analgesia.Pati...
supported by grants from the National Research Foundation of Korea funded by the Korean government(NRF-2017R1A2B4009963,to JYO,TYH,JHJ and HJP);from the Korea Institute of Oriental Medicine(grant K18182,to JYP,YR and HJP)。
Despite numerous efforts to overcome neuropathic pain,various pharmacological drugs often fail to meet the needs and have many side effects.Muscovite is an aluminosilicate mineral that has been reported to have an ant...
supported by grants from the National Institutes of Health(NIH;K08 AR060164-01A);the Department of Defense(DoD;W81XWH-16-1-0725)to JCE;institutional support from the University of Rochester and Pennsylvania State University Medical Centers。
4-Aminopyridine(4-AP), an FDA-approved drug for the symptomatic treatment of multiple sclerosis, is used to improve neuromuscular function in patients with diverse demyelinating disorders. We recently demonstrated tha...
supported by the Priority Academic Program Development of Jiangsu Higher Education Institutions of China PAPD。
Previous research revealed the positive activity of matrix metalloproteinase 7(MMP7) on migration and myelin regeneration of Schwa nn cells(SCs). However, understanding of the molecular changes and biological activiti...
supported by grants from the National Natural Science Foundation of China,No.81872699(to MS);Key project of Shaanxi Province,China,No.2017ZDXM-SF-043(to MS);the Military Medical Science and Technology Youth Development Program,China,No.19QNP061(to CL)
Olfactory ensheathing cells(OECs)are promising seed cells for nerve regeneration.However,their application is limited by the hypoxic environment usually present at the site of injury.Exosomes derived from human umbili...
supported by the National Natural Science Foundation of China,No.81460198,31260233;the National Institute of Health of the United States of American,No.R01NS064288,R01NS085176,R01EY027347(to FQZ);the Craig H.Neilson Foundation,the Bright Focus Foundation(to FQZ)
Most current studies quantify axon regeneration by immunostaining regeneration-associated proteins,representing indirect measurement of axon lengths from both sensory neurons in the dorsal root ganglia and motor neuro...
supported by the National Natural Science Foundation of China,No.81371353(to XPD)
The Slit family of axon guidance cues act as repulsive molecules for precise axon pathfinding and neuronal migration during nervous system development through interactions with specific Robo receptors.Although we prev...