AMYLOIDOSIS

作品数:117被引量:124H指数:6
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相关领域:医药卫生更多>>
相关作者:戚晓平吉晓滨梁赐芳蔡昊段明辉更多>>
相关机构:广州市第一人民医院解放军第一一七医院中国人民解放军北京协和医院更多>>
相关期刊:更多>>
相关基金:国家自然科学基金国家重点基础研究发展计划上海市自然科学基金更多>>
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Design and redesign journey of a drug for transthyretin amyloidosis
《Neural Regeneration Research》2025年第4期1096-1097,共2页Francisca Pinheiro Salvador Ventura 
funded by the Spanish Ministry of Science and Innovation(PDC2021-120914-I00);the Universitat Autònoma de Barcelona(PROOF OF CONCEPT 2020);ICREA,ICREA-Academia 2015 and 2020(to SV).
The misfolding and subsequent aggregation of proteins into amyloid fibrils underlie the onset of a variety of human disorders collectively known as amyloidosis.Transthyretin(TTR)is one of the>30 amyloidogenic proteins...
关键词:AMYLOID aggregation SENILE 
Nanochaperones Based on Hydrophobic Interaction and Coordination Inhibit Protein Misfolding and Fibrillation
《Chinese Journal of Polymer Science》2024年第11期1710-1718,I0009,共10页Hui Wang Lin-Lin Xu Lin-Qi Shi Ru-Jiang Ma 
financially supported by the National Key R&D Program of China(No.2022YFA1205700);the National Natural Science Foundation of China(Nos.51933006,52293383 and 52303188);the Natural Science Foundation of Tianjin,China(No.23JCYBJC01780);China Postdoctoral Science Foundation Funded Project(No.2023M731786)。
Amyloidosis is characterized by the deposition of fibrillar aggregates,with a specific peptide or protein as the primary component,in affected tissues or organs.Excessive proliferation and deposition of amyloid fibril...
关键词:Nanochaperone AMYLOIDOSIS INSULIN hIAPP Inhibit fibrillation 
Changes in the clinical features,treatments,and outcomes of patients with systemic light chain(AL)amyloidosis in Western China,2010-2022:A multicenter,retrospective,real-world study
《Chinese Medical Journal》2024年第21期2624-2626,共3页Hongbin Yu Lei Zhao Jiawei Li Chunlan Zhang Qinyu Liu Jie Zhou Fang Xu Jian Xiao Ying Yuan Siyu Yan Yucheng Chen Qing Zhang Huifang Shang Zhangxue Hu Yu Wu 
To the Editor:Systemic light chain(AL)amyloidosis,a rare and deadly disease affecting approximately 10 individuals per million each year worldwide,is marked by misfolded,aggregated immunoglobulin light chains produced...
关键词:AMYLOID PATIENTS clinical 
Periorbital purpura can be the only initial symptom of primary light chain amyloidosis:A case report
《World Journal of Clinical Cases》2024年第26期5946-5951,共6页Xiu-Feng Wang Ting Li Man Yang Yan Huang 
Supported by the Henan Province Medical Science and Technology Research Plan Joint Construction Project,No.LHGJ20210533;Xinxiang Science and Technology Research Project,No.GG2020029.
BACKGROUND Primary light chain amyloidosis is a rare and complex disease with complex clinical features and is highly susceptible to misdiagnosis and underdiagnosis in the early stages.CASE SUMMARY We report a case of...
关键词:Primary light chain amyloidosis Periorbital purpura Initial symptom Literature review Case report 
Carpal Tunnel Syndrome: A Marker for Amyloidosis
《World Journal of Neuroscience》2024年第3期92-101,共10页Luciana León Cejas Miguel Saucedo Mayra Aldecoa Gustavo Teruya Fabricio Silva Alvaro Muratore Gonzalo Viollaz Cintia Marchesoni Ana Pardal Pablo Dezanzo Alejandro Iotti Ricardo Reisin 
Introduction: Amyloidosis are systemic conditions and carpal tunnel syndrome (CTS) precedes the principal systemic complications and can be used as an early marker. Our objective was to determine the frequency of amyl...
关键词:Carpal Tunnel AMYLOID TRANSTHYRETIN Amyloid Cardiac Transthyretin Variants Light Chains 
金属纳米伴侣界面金属原子对淀粉样蛋白纤维化的调控作用
《Science China Materials》2024年第7期2345-2354,共10页李虎 高冠斌 余良翀 张子俊 张斌 邓昱周 慕庆雪 沈雷 孙涛垒 
We acknowledge the National Natural Science Foundation of China(52273110,21975191,52372271 and 22173070);the Youth Top Talent Project of Hubei Provence(GGB);the Knowledge Innovation Program of Wuhan-Shuguang Project(GGB);the Fundamental Research Funds for the Central Universities(WUT:2023III013GX)for financial supports.
合成具有生物分子伴侣功能的金属纳米伴侣作为调节蛋白质构象的候选物具有良好的应用前景.尽管对金属纳米伴侣已有广泛研究,但其分子中界面金属原子对蛋白质构象的调控作用及其机制尚不清楚,这严重阻碍了对高性能金属纳米伴侣的开发.本...
关键词:customizing nano-chaperone nano-interface gold-nanoclusters peptide amyloidosis 
Extensive Bi-Atrial Remodeling on Hypertensive Patient with Permanent Atrial Fibrillation Delayed Diagnosis of Fatal Cardiac Lambda Amyloidosis
《World Journal of Cardiovascular Diseases》2024年第6期409-420,共12页Houzéiph Abdou Lassissi Ngardjibem Djita Ibrahima Sory Sylla Thome Masset Abdelrhani Moumen Sedjolo Emmanuelle Bibiane Kpomalegni 
Background: Amyloidosis is a disease characterized by the deposition of fibrillar proteins in tissues. The nature of the protein defines the type of amyloidosis. Cardiac involvement is most often secondary to deposits...
关键词:MYELOMA Cardiac Lambda Light Chain Amyloidosis Monoclonal Gammopathy Heart Failure 
Insights into renal and urological complications of inflammatory bowel disease
《World Journal of Nephrology》2024年第3期9-25,共17页Anmol Singh Tejasvini Khanna Diksha Mahendru Jasraj Kahlon Vikash Kumar Aalam Sohal Juliana Yang 
Inflammatory bowel disease(IBD)is a chronic condition characterized by immune-mediated inflammation in the gastrointestinal tract,which follows a relapsing and remitting course.Apart from affecting the gastrointestina...
关键词:Inflammatory bowel disease GLOMERULONEPHRITIS AMYLOIDOSIS Extra-intestinal manifestations NEPHROTOXICITY chronic kidney disease 
Systemic Amyloidosis Secondary to Psoriasis: A Rare, Autoimmune and Genetically-Determined Disorder That Is Amenable to Treatment with Cyclosporin A—Cyclosporin A for Psoriasis-Induced Amyloidosis
《Open Journal of Nephrology》2024年第2期226-232,共7页Kamel El-Reshaid Shaima Al-Bader John Patrick Madda 
Background: Systemic secondary amyloidosis (SSA) is associated with chronic inflammatory disorders and/or chronic infections. Patients and Methods: Over the past 10 years;a total of 21 patients, with long-term (17 mon...
关键词:AMYLOIDOSIS PSORIASIS Nephrotic Syndrome Cyclosporin A 
Single-center retrospective analysis of efficacy and safety of daratumumab plus dexamethasone for light chain amyloidosis nephropathy
《China Medical Abstracts(Internal Medicine)》2024年第2期112-113,共2页薛韩 
Objective To analyze the efficacy and safety of daratumumab plus dexamethasone in the treatment of renal injury patients with light chain amyloidosis,and to provide clinical reference.Methods It was a single center re...
关键词:diagnosis ENDOSCOPIC treatment 
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