funded by the Spanish Ministry of Science and Innovation(PDC2021-120914-I00);the Universitat Autònoma de Barcelona(PROOF OF CONCEPT 2020);ICREA,ICREA-Academia 2015 and 2020(to SV).
The misfolding and subsequent aggregation of proteins into amyloid fibrils underlie the onset of a variety of human disorders collectively known as amyloidosis.Transthyretin(TTR)is one of the>30 amyloidogenic proteins...
financially supported by the National Key R&D Program of China(No.2022YFA1205700);the National Natural Science Foundation of China(Nos.51933006,52293383 and 52303188);the Natural Science Foundation of Tianjin,China(No.23JCYBJC01780);China Postdoctoral Science Foundation Funded Project(No.2023M731786)。
Amyloidosis is characterized by the deposition of fibrillar aggregates,with a specific peptide or protein as the primary component,in affected tissues or organs.Excessive proliferation and deposition of amyloid fibril...
To the Editor:Systemic light chain(AL)amyloidosis,a rare and deadly disease affecting approximately 10 individuals per million each year worldwide,is marked by misfolded,aggregated immunoglobulin light chains produced...
Supported by the Henan Province Medical Science and Technology Research Plan Joint Construction Project,No.LHGJ20210533;Xinxiang Science and Technology Research Project,No.GG2020029.
BACKGROUND Primary light chain amyloidosis is a rare and complex disease with complex clinical features and is highly susceptible to misdiagnosis and underdiagnosis in the early stages.CASE SUMMARY We report a case of...
Introduction: Amyloidosis are systemic conditions and carpal tunnel syndrome (CTS) precedes the principal systemic complications and can be used as an early marker. Our objective was to determine the frequency of amyl...
We acknowledge the National Natural Science Foundation of China(52273110,21975191,52372271 and 22173070);the Youth Top Talent Project of Hubei Provence(GGB);the Knowledge Innovation Program of Wuhan-Shuguang Project(GGB);the Fundamental Research Funds for the Central Universities(WUT:2023III013GX)for financial supports.
Background: Amyloidosis is a disease characterized by the deposition of fibrillar proteins in tissues. The nature of the protein defines the type of amyloidosis. Cardiac involvement is most often secondary to deposits...
Inflammatory bowel disease(IBD)is a chronic condition characterized by immune-mediated inflammation in the gastrointestinal tract,which follows a relapsing and remitting course.Apart from affecting the gastrointestina...
Background: Systemic secondary amyloidosis (SSA) is associated with chronic inflammatory disorders and/or chronic infections. Patients and Methods: Over the past 10 years;a total of 21 patients, with long-term (17 mon...
Objective To analyze the efficacy and safety of daratumumab plus dexamethasone in the treatment of renal injury patients with light chain amyloidosis,and to provide clinical reference.Methods It was a single center re...