SENILE

作品数：208被引量：365H指数：10
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相关领域：医药卫生更多>>
相关作者：王振宇任幼红钟蓝李波董冰更多>>
相关机构：航空工业中心医院成都中医药大学郑州大学第一附属医院山西医科大学更多>>
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相关基金：国家自然科学基金广西壮族自治区自然科学基金中国博士后科学基金广东省自然科学基金更多>>
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Design and redesign journey of a drug for transthyretin amyloidosis
《Neural Regeneration Research》2025年第4期1096-1097,共2页Francisca Pinheiro Salvador Ventura 
funded by the Spanish Ministry of Science and Innovation(PDC2021-120914-I00);the Universitat Autònoma de Barcelona(PROOF OF CONCEPT 2020);ICREA,ICREA-Academia 2015 and 2020(to SV).
The misfolding and subsequent aggregation of proteins into amyloid fibrils underlie the onset of a variety of human disorders collectively known as amyloidosis.Transthyretin(TTR)is one of the>30 amyloidogenic proteins...
关键词：AMYLOID aggregation SENILE 
Clinical Study on the Treatment of Senile Alzheimer’s Dementia with Sodium Oligomannate Combined with Memantine Hydrochloride
《Journal of Clinical and Nursing Research》2024年第10期208-217,共10页Jian Zhao Xi Li Xuelian Jia Ganke Gao 
Clinical Special Project of Fujian University of Traditional Chinese Medicine(Project Number:XB2023027)。
Objective:To analyze the clinical effects of sodium oligomannate combined with memantine hydrochloride in the treatment of senile Alzheimer’s dementia.Methods:Sixty-eight cases of Alzheimer’s dementia treated at the...
关键词：Senile Alzheimer’s dementia Sodium oligomannate Memantine hydrochloride Cognitive function TREATMENT 
Rejuvenation of BMSCs senescence by pharmacological enhancement of TFEB-mediated autophagy alleviates aged-related bone loss and extends lifespan in middle aged mice
《Bone Research》2024年第3期661-674,共14页Ziwei Luo Wanyi Wei Dawei Qiu Zixia Su Liangpu Liu Honghai Zhou Hao Cui Li Yang 
supported by grants from Science and Technology Planning Project of Guangxi Zhuang Autonomous Region (Guike AD19245094,AD19245096);Doctoral Foundation of Guangxi University of Chinese Medicine (XP018148);Guangxi Key Laboratory of Efficacy Study on Chinese Materia Medica,2020 (20-065-38)。
Bone marrow stromal/stem cells(BMSCs)are generally considered as common progenitors for both osteoblasts and adipocytes in the bone marrow,but show preferential differentiation into adipocytes rather than osteoblasts ...
关键词：SENILE osteoporosis PROGENITOR 
Biodegradable Zn-2Cu-0.5Zr alloy promotes the bone repair of senile osteoporotic fractures via the immune-modulation of macrophages
《Bioactive Materials》2024年第8期422-437,共16页Huanzhong Ji Gang Shen Hanghang Liu Yao Liu Junyu Qian GuoJiang Wan En Luo 
supported by Grants from the National Natural Science Foundation of China(82370932);Research and Develop Program,West China Hospital of Stomatology Sichuan University(RD-03-202102);Program of Science and Technology Department of Sichuan Province(2023ZYD0107).The authors declare no potential conflicts of interest with respect to the authorship and/or publication of this article.
Delayed bone-healing of senile osteoporotic fractures remains a clinical challenge due to the alterations caused by aging in bone and immune systems.The novel biomaterials that address the deficiencies in both skeleta...
关键词：Zinc-based biodegradable metals Macrophage Bone regeneration Immune-osteo microenvironment Senile osteoporotic bone fracture healing 
Transforming growth factor-β1 and vascular endothelial growth factor levels in senile acute myeloid leukemia and correlation with prognosis
《World Journal of Clinical Cases》2024年第20期4121-4129,共9页Wan Li Sheng-Yu Ma Hui-Ying Zhao 
the Ethic Committee of Suzhou Hospital of Anhui Medical University(Approval No.C2024003).
BACKGROUND Acute myeloid leukemia(AML)is a disease in which immature hematopoietic cells accumulate in the bone marrow and continuously expand,inhibiting hematopoiesis.The treatment and prognosis of this disease have ...
关键词：Acute myeloid leukemia Transforming growth factor-β1 Vascular endothelial growth factor Expression level Prognostic correlation 
Insight into endoplasmic reticulum-mitochondria contacts in human amyotrophic lateral sclerosis
《Neural Regeneration Research》2024年第7期1407-1408,共2页Naomi Hartopp Andrea Markovinovic Christopher CJ Miller Patricia Gomez-Suaga 
supported by grants from the UK Medical Research Council (MR/R022666/1);Alzheimer’s Disease Society (AlzSoc-28 7);Alzheimer’s Research UK (ARUK-PG2017B-3 and ARUK-DC2019-009) to CCJM;a Motor Neurone Disease Association Fellowship to PGS and a King’s College Guy’s and St Thomas’s studentship to NH;PGSis supported by an MSCA-Sealof Excellence-HEALTH fellowship (IHMC22/00025) from the Instituto de Salud CarlosⅢ(ISCⅢ);funded by the"Mecanismo para la Recuperacion y la Resiliencia"(MRR) program from The NextGenerationEU funds (European Union);by Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas-lnstituto de Salud CarlosⅢ(CIBER-CIBERNED-ISCⅢ)(CB06/05/0041)。
Amyotrophic lateral sclerosis(ALS) is a fastprogressing fatal neurodegenerative disease and the most common form of motor neuron disease.There is currently no cure and approximately 90% of cases are sporadic.ALS share...
关键词：SENILE SCLEROSIS 
Clinical characteristics and impactof comorbidities on the prognosis of senileepilepsy in Southwest China:a retrospectivecohort study
《Acta Epileptologica》2024年第2期100-109,共10页Zhen Cao Yinping Li Shengyi Liu Zihua He Jinmei Li 
Background Senile epilepsy and its comorbidities pose a tremendous burden on patients and the society.Thisstudy was aimed to investigate the clinical characteristics and comorbidities of senile epilepsy,as well as the...
关键词：Senile epilepsy Elderly EPILEPSY COMORBIDITY PROGNOSIS 
Effect of Wenshen Tongluo Zhitong recipe on the interventionof autophagy onsenile osteoporosis mice model by AMPK/mTOR signaling pathway
《China Medical Abstracts(Internal Medicine)》2024年第2期79-80,共2页牛园园 
Objective To study the intervention effects and mechanism of Wenshen Tongluo Zhitong Recipe(WTZR)on senile osteoporosis(SOP)model mice.Methods Sixty 6-month-old male C57BL/6J mice were randomly divided into six groups...
关键词：SENILE OSTEOPOROSIS INJECTION 
Assessing the current situation and the influencing factors affecting perceived stigma among older patients after leukemia diagnosis
《World Journal of Psychiatry》2024年第6期812-821,共10页Xuan Tang Shuang-Qin Chen Jiang-Hua Huang Cai-Feng Deng Jie-Qiong Zou Juan Zuo 
BACKGROUND Psychological problems are becoming increasingly prominent among older patients with leukemia,with patients potentially facing stigmatization after diagnosis.However,there is limited research on the stigma ...
关键词：Senile leukemia STIGMA Social support ANXIETY DEPRESSION Influencing factors 
Deciphering tau-related dementia using human iPSC lines: electrophysiological perspectives of future studies被引量：1
《Neural Regeneration Research》2022年第12期2672-2674,共3页Olga Kopach 
To date,no disease-modifying treatment or cure is available for dementia.This disorder is becoming more common as the global population ages.There has been over several decades of extensive research focusing on how th...
关键词：SENILE PATHOLOGY eventually 
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