Rejuvenation of BMSCs senescence by pharmacological enhancement of TFEB-mediated autophagy alleviates aged-related bone loss and extends lifespan in middle aged mice  

作　　者：Ziwei Luo Wanyi Wei Dawei Qiu Zixia Su Liangpu Liu Honghai Zhou Hao Cui Li Yang 

机构地区：[1]College of Orthopedics,Guangxi University of Chinese Medicine,Nanning 530200 Guangxi,China [2]Faculty of Chinese Medicine Science,Guangxi University of Chinese Medicine,Nanning 530200 Guangxi,China [3]Department of Physical Education,Guangxi University of Chinese Medicine,Nanning 530200 Guangxi,China [4]Guangxi Key Laboratory of Efficacy Study on Chinese Materia Medica,Guangxi University of Chinese Medicine,Nanning 530200 Guangxi,China [5]College of Pharmacy,Guangxi University of Chinese Medicine,Nanning 530200 Guangxi,China [6]Key Laboratory of Biorheological Science and Technology,Ministry of Education,Bioengineering College,Chongqing University,Chongqing 400030,China

出　　处：《Bone Research》2024年第3期661-674,共14页骨研究（英文版）

基　　金：supported by grants from Science and Technology Planning Project of Guangxi Zhuang Autonomous Region (Guike AD19245094,AD19245096);Doctoral Foundation of Guangxi University of Chinese Medicine (XP018148);Guangxi Key Laboratory of Efficacy Study on Chinese Materia Medica,2020 (20-065-38)。

摘　　要：Bone marrow stromal/stem cells(BMSCs)are generally considered as common progenitors for both osteoblasts and adipocytes in the bone marrow,but show preferential differentiation into adipocytes rather than osteoblasts under aging,thus leading to senile osteoporosis.Accumulated evidences indicate that rejuvenation of BMSCs by autophagic enhancement delays bone aging.

关 键 词：SENILE osteoporosis PROGENITOR 

分 类 号：R580[医药卫生—内分泌]