Insights into renal and urological complications of inflammatory bowel disease  

作　　者：Anmol Singh Tejasvini Khanna Diksha Mahendru Jasraj Kahlon Vikash Kumar Aalam Sohal Juliana Yang 

机构地区：[1]Department of Medicine,Tristar Centennial Medical Center,Nashville,TN 37203,United States [2]Department of Medicine,Maulana Azad Medical College,New Delhi 110002,India [3]Department of Medicine,Dayanand Medical College and Hospital,Ludhiana 141001,Punjab,India [4]Department of Internal Medicine,Abrazo Medical Center,Phoenix,AZ 85015,United States [5]Department of Medicine,The Brooklyn Hospital Center,Brooklyn,NY 11201,United States [6]Department of Hepatology,Liver Institute Northwest,Seattle,WA 98105,United States [7]Division of Gastroenterology and Hepatology,University of Texas Medical Branch,Galveston,TX 77555,United States

出　　处：《World Journal of Nephrology》2024年第3期9-25,共17页世界肾病学杂志（英文版）

摘　　要：Inflammatory bowel disease(IBD)is a chronic condition characterized by immune-mediated inflammation in the gastrointestinal tract,which follows a relapsing and remitting course.Apart from affecting the gastrointestinal tract,IBD also has extra-intestinal manifestations(EIMs).While the etiology of extraintestinal manifestation remains unclear,it is theorized to be based on immunological responses influenced by genetic factors.Renal involvement is one of the EIMs observed in ulcerative colitis and Crohn’s disease.The renal manifes-tations in IBD patients encompass a range of conditions including nephrolithiasis,amyloidosis,tubulointerstitial nephritis,glomerulonephritis(GN),obstructive pathologies,and chronic kidney disease(CKD).The incidence of CKD in IBD patients varies from 5%-15%.The decline in renal function can stem from various factors such as direct inflammatory damage to the kidneys leading to glomerular or tubular injury,or from complications like recurrent stones,amyloidosis,or GN.Additionally,nephrotoxic medications used in treating IBD,such as TNF-αinhibitors,calcineurin inhibitors,and aminosalicylates,can exacerbate the decline in renal function.Currently,there is a lack of consensus regarding these patients'screening and renal function monitoring.This review aims to assess the existing literature on the different renal complications among individuals with IBD,shedding light on their pathophysiology and management.

关 键 词：Inflammatory bowel disease GLOMERULONEPHRITIS AMYLOIDOSIS Extra-intestinal manifestations NEPHROTOXICITY chronic kidney disease 

分 类 号：R692[医药卫生—泌尿科学]