T cell interactions with microglia in immune-inflammatory processes of ischemic stroke  

作　　者：Yuxiao Zheng Zilin Ren Ying Liu Juntang Yan Congai Chen Yanhui He Yuyu Shi Fafeng Cheng Qingguo Wang Changxiang Li Xueqian Wang 

机构地区：[1]School of Traditional Chinese Medicine,Beijing University of Chinese Medicine,Beijing,China [2]Library,Beijing University of Chinese Medicine,Beijing,China [3]Dongzhimen Hospital,Beijing University of Chinese Medicine,Beijing,China

出　　处：《Neural Regeneration Research》2025年第5期1277-1292,共16页中国神经再生研究（英文版）

基　　金：supported by the National Natural Science Foundation of China,Nos.82104560(to CL),U21A20400(to QW);the Natural Science Foundation of Beijing,No.7232279(to XW);the Project of Beijing University of Chinese Medicine,No.2022-JYB-JBZR-004(to XW)。

摘　　要：The primary mechanism of secondary injury after cerebral ischemia may be the brain inflammation that emerges after an ischemic stroke,which promotes neuronal death and inhibits nerve tissue regeneration.As the first immune cells to be activated after an ischemic stroke,microglia play an important immunomodulatory role in the progression of the condition.After an ischemic stroke,peripheral blood immune cells(mainly T cells)are recruited to the central nervous system by chemokines secreted by immune cells in the brain,where they interact with central nervous system cells(mainly microglia)to trigger a secondary neuroimmune response.This review summarizes the interactions between T cells and microglia in the immune-inflammatory processes of ischemic stroke.We found that,during ischemic stroke,T cells and microglia demonstrate a more pronounced synergistic effect.Th1,Th17,and M1 microglia can co-secrete proinflammatory factors,such as interferon-γ,tumor necrosis factor-α,and interleukin-1β,to promote neuroinflammation and exacerbate brain injury.Th2,Treg,and M2 microglia jointly secrete anti-inflammatory factors,such as interleukin-4,interleukin-10,and transforming growth factor-β,to inhibit the progression of neuroinflammation,as well as growth factors such as brain-derived neurotrophic factor to promote nerve regeneration and repair brain injury.Immune interactions between microglia and T cells influence the direction of the subsequent neuroinflammation,which in turn determines the prognosis of ischemic stroke patients.Clinical trials have been conducted on the ways to modulate the interactions between T cells and microglia toward anti-inflammatory communication using the immunosuppressant fingolimod or overdosing with Treg cells to promote neural tissue repair and reduce the damage caused by ischemic stroke.However,such studies have been relatively infrequent,and clinical experience is still insufficient.In summary,in ischemic stroke,T cell subsets and activated microglia act synergistically to regulate inflamm

关 键 词：BRAIN IMMUNE INFLAMMATION interaction ischemic stroke mechanism MICROGLIA NEURON secondary injury T cells 

分 类 号：R743.3[医药卫生—神经病学与精神病学]