SUBICULUM

作品数：9被引量：21H指数：3
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相关领域：医药卫生更多>>
相关作者：马兰李浩洪康林戴正泽更多>>
相关机构：复旦大学上海医学院四川大学华西医院更多>>
相关期刊：《Chinese Medical Journal》《Neuroscience Bulletin》《Acta Pharmacologica Sinica》《Neural Regeneration Research》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划更多>>
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Low-frequency Stimulation at the Subiculum Prevents Extensive Secondary Epileptogenesis in Temporal Lobe Epilepsy被引量：1
《Neuroscience Bulletin》2024年第5期564-576,共13页Yujia Shen Yiwei Gong Xiaoli Da Shajing Gao Shuo Zhang Minjuan Sun Yuanzhi Yang Xiaoyun Qiu Menghan Li Yang Zheng Fan Fei Yi Wang Zhong Chen Cenglin Xu 
supported by grants from the National Natural Science Foundation of China(U21A20418 and 82173796);the Natural Science Foundation of Zhejiang Province(LD22H310003);the Research Project of Zhejiang Chinese Medical University(2023JKZDZC04).
Secondary epileptogenesis is characterized by increased epileptic susceptibility and a tendency to generate epileptiform activities outside the primary focus.It is one of the major resultants of pharmacoresistance and...
关键词：Secondary epileptogenesis Low-frequency stimulation SUBICULUM Temporal lobe epilepsy 
(+)-Borneol enantiomer ameliorates epileptic seizure via decreasing the excitability of glutamatergic transmission被引量：3
《Acta Pharmacologica Sinica》2023年第8期1600-1611,共12页Yu Wang Xiao-yun Qiu Jia-ying Liu Bei Tan Fei Wang Min-juan Sun Xu-hong Jiang Xu-ming Ji Ceng-lin Xu Yi Wang Zhong Chen 
supported by grants from the National Key R&D Program of China (2021ZD0202803 and 2020YFA0803902);the National Natural Science Foundation of China (82022071);the Natural Science Foundation of Zhejiang Province (LD22H310003);the Research Project of Zhejiang Chinese Medical University (2022JKJNTZ13).
Epilepsy is one common brain disorder,which is not well controlled by current pharmacotherapy.In this study we characterized the therapeutic potential of borneol,a plant-derived bicyclic monoterpene compound,in the tr...
关键词：epilepsy anti-seizure drug (+)-borneol valproate SUBICULUM glutamatergic synaptic transmission 
Basal Forebrain Cholinergic Innervation Induces Depression-Like Behaviors Through Ventral Subiculum Hyperactivation
《Neuroscience Bulletin》2023年第4期617-630,共14页Nana Yu Huina Song Guangpin Chu Xu Zhan Bo Liu Yangling Mu Jian-Zhi Wang Yisheng Lu 
supported by grants from National Natural Science Foundation of China(82071508,31771190,31730035).
Malfunction of the ventral subiculum(vSub),the main subregion controlling the output connections from the hippocampus,is associated with major depressive disorder(MDD).Although the vSub receives cholinergic innervatio...
关键词：Depression Medial septum SUBICULUM ACETYLCHOLINE Circuit 
Low-frequency Stimulation at the Subiculum is Anti-convulsant and Anti-drug-resistant in a Mouse Model of Lamotrigine-resistant Temporal Lobe Epilepsy被引量：7
《Neuroscience Bulletin》2020年第6期654-658,共5页Yeping Ruan Cenglin Xu Jile Lan Jiazhen Nao Shuo Zhang Fei Fan Yi Wang Zhong Chen 
supported by grants from the National Natural Science Foundation of China (81703480 and 81603084);the Fundamental Research Funds for Central Universities,China (2019FZA7016 and 2019QNA5001).
Dear Editor,Epilepsy is a common neurological disease.About 30%of epileptic patients develop resistance to antiepileptic drugs(AEDs),and are considered to have refractory or drugresistant epilepsy[1].Based on the time...
关键词：EPILEPSY drug drugs 
Subicular pyramidal neurons gate drug resistance in temporal lobe epilepsy
《中国药理学与毒理学杂志》2018年第9期722-723,共2页XU Ceng-lin WANG Yi CHEN Zhong 
National Natural Science Foundation of China(91332202,81630098,81521062,81671282,81703480).
OBJECTIVE To understand the underlying mechanisms of drug resistant temporal lobe epilepsy(TLE).METHODS In vivo and vitro electrophysiology,optogenetics and chemogenetics were used in a classic multi-drug resistant TL...
关键词：temporal LOBE EPILEPSY SUBICULUM PYRAMIDAL NEURONS 
Memory Dysfunction in Type 2 Diabetes Mellitus Correlates with Reduced Hippocampal CA1 and Subiculum Volumes被引量：9
《Chinese Medical Journal》2015年第4期465-471,共7页Yan-Wei Zhang Jiu-Quan Zhang Chen Liu Ping Wei Xiao Zhang Qiao-Ying Yuan Xun-Tao Yin Lu-Qing Wei Jin-Guo Cui Jian Wang 
This study was financially supported by the Innovation Fund for Younger Investigators of Southwest Hospital of the Third Military Medical University，the National Natural Science Foundation of China
Background：Little attention has been paid to the role of subcortical deep gray matter （SDGM） structures in type 2 diabetes mellitus （T2DM）-induced cognitive impairment,especially hippocampal subfields.Our aims we...
关键词：Cognitive Impairment Hippocampus Type 2 Diabetes Mellitus Subcortical Deep Gray Matter Structures Volume 
Expression of N-methyl-D-aspartic acid 2A-B and 2B receptors in anterior thalamic nucleus and subiculum complex of rats被引量：1
《Neural Regeneration Research》2008年第8期822-825,共4页Yuanshan Fu Xiaokai Ma Xiaoling Yue Bin Wang 
the National Natural Science Foundation of China, No. 30470551;a Category Project of the Education Department of Liaoning Province, No. 05L1021
BACKGROUND：Glutamate acid ionotropic receptor N-methyl-D-aspartic acid （NMDA） takes part in long-term potentiation, thereby influencing the process of learning and memory. OBJECTIVE： To verify expression of NMDA 2...
关键词：anterior thalamic nucleus learning MEMORY NMDA receptor RATS subiculum complex 
Environmental cues associated with morphine modulate release of glutamate and γ-aminobutyric acid in ventral subiculum被引量：2
《Neuroscience Bulletin》2006年第5期255-260,共6页康林 戴正泽 李浩洪 马兰 
supported by the National Natural Science Foundation of China(No.30230130 and No.30400129);the Ministry of Science and Technology of China(No.2003CB515405,No.2005CB522406);the Program for Changjiang Scholars and Innovative Research Team of Ministry of Education of China;Shanghai Municipal Commission for Science and Technology(No.06JC14008).
Objective To investigate whether environmental cues associated with different properties of morphine could regulate the extracellular levels of glutamate and y-aminobutyric acid （GABA） in the hippocampal ventral sub...
关键词：conditioning place preference conditioning place aversion ventral subiculum MICRODIALYSIS γ-aminobutyric acid GLUTAMATE 
Environmental cues associated with rewarding and aversive properties of morphine induce activation of ventral subiculum through distinct neurotransmitters
《中国药理通讯》2005年第4期12-12,共1页Lin Kang Zhengze Dai Haohong Li Lan Ma 
关键词：吗啡 活化作用 环境因素 药理作用 
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