KINESIN

作品数:75被引量:88H指数:5
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相关领域:生物学医药卫生更多>>
相关作者:潘俊敏刘梅侯聪聪李洁龄董伟光更多>>
相关机构:浙江大学中国海洋大学中国科学院大学中国农业大学更多>>
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相关基金:国家自然科学基金河北省自然科学基金国家重点基础研究发展计划河南省高校科技创新团队支持计划更多>>
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Endophilin A2 controls touch and mechanical allodynia via kinesin-mediated Piezo2 trafficking
《Military Medical Research》2025年第2期157-183,共27页Man-Xiu Xie Ren-Chun Lai Yi-Bin Xiao Xi Zhang Xian-Ying Cao Xiao-Yu Tian An-Nan Chen Zi-Yi Chen Yan Cao Xiao Li Xiao-Long Zhang 
National Natural Science Foundation of China(82271241 and 82001172 to XLZ,81801112 to MXX);Guangdong Basic and Applied Basic Research Foundation(2022A1515012389 to MXX,2022A1515012543 to RCL);Young Talent Support Project of Guangzhou Association for Science and Technology(QT20220101169 to XLZ);Excellent Young Talents Project of Guangdong Provincial People’s Hospital,Guangdong Academy of Medical Sciences(KY012021188 to XLZ);Science and Technology Projects in Guangzhou(202201010792 to RCL)。
Background Tactile and mechanical pain are crucial to our interaction with the environment,yet the underpinning molecular mechanism is still elusive.Endophilin A2(EndoA2)is an evolutionarily conserved protein that is ...
关键词:Endophilin A2 TOUCH Mechanical allodynia Piezo2 KIF5B 
Kinesin family member 14 expression and its clinical implications in colorectal cancer
《World Journal of Gastrointestinal Oncology》2025年第3期299-321,共23页Kai Qin Jia-Yuan Luo Da-Tong Zeng Wan-Ying Huang Bin Li Qi Li Yan-Ting Zhan Rong-Quan He Wei-Jian Huang Gang Chen Zu-Yuan Chen Bang-Teng Chi Yu-Xing Tang Rui-Xue Tang Hui Li 
Natural Science Foundation of Shandong Province,No.ZR2020QH185;Scientific Research Nurturing Fund of The First Affiliated Hospital of Shandong First Medical University&Shandong Provincial Qianfoshan Hospital,No.QYPY2020NSFC0803;Guangxi Zhuang Autonomous Region Health Commission Scientific Research Project,No.Z-A20220415;Guangxi Medical University Teacher Teaching Ability Development Project,No.2022JFA02;Guangxi Medical University Undergraduate Education and Teaching Reform Project,No.2023Y05.
BACKGROUND Colorectal cancer(CRC)is the third most common cancer globally,causing over 900000 deaths annually.Risk factors include aging,diet,obesity,sedentary lifestyle,tobacco use,genetic predisposition,and inflamma...
关键词:Colorectal cancer Kinesin family member 14 Nitidine chloride Molecular docking Standardized mean difference 
Mechanistic link between long noncoding RNA and stability of oncogene reveals stemness and chemoresistance of hepatocellular carcinoma
《World Journal of Gastroenterology》2025年第7期160-162,共3页Yu-Bo Liang Xing-Ming Chen Wan-Ling Luo Yang Ke 
Supported by the National Natural Science Foundation of China,No.82103173 and No.82460461;Medical Subject Leader of Yunnan Province(General Surgery),No.D-2024029;Yunnan Fundamental Research Project for Excellent Young Scholars,No.202401AW070003;the Young and Mid-aged Academic and Technical Leader Reserve Talent Program of Yunnan Province,No.202205AC160063。
This letter comments on the recently published manuscript by Yu et al,in which the authors revealed a novel mechanism by which the m6A-modified long noncoding RNA kinesin family member 9-antisense RNA 1 promotes stemn...
关键词:Kinesin family member 9-antisense RNA 1 Hepatocellular carcinoma Ubiquitin-specific peptidase 1 Short stature homeobox 2 CHEMORESISTANCE 
On load dependence of detachment rate of kinesin motor
《Chinese Physics B》2025年第1期498-505,共8页Xiao-Xuan Shi Yao Wang Yu-Ru Liu Ping Xie 
Project supported by Youth Project of Science and Technology Research Program of Chongqing Education Commission of China (Grant No. KJQN202404522)。
Kinesin is an archetypal microtubule-based molecular motor that can generate force to transport cargo in cells. The load dependence of the detachment rate is an important factor of the kinesin motor, the determination...
关键词:KINESIN detachment rate generated force chemomechanical coupling mechanism optical trapping 
Engineering The Neck Hinge Reshapes The Processive Movement of Kinesin-3
《生物化学与生物物理进展》2024年第10期2730-2740,共11页LI Dong REN Jin-Qi SONG Yin-Long LIANG Xin FENG Wei 
北京市自然科学基金(5242021);中国科学院战略性先导科技专项(XDB37020302);国家自然科学基金(32071191,32371273);科技创新2030-“脑科学与类脑研究”重大项目(2022ZD0205800);中国科学院稳定支持基础研究领域青年团队计划(075)资助。
Objective In kinesin-3,the neck coil correlates with the following segments to form an extended neck that contains a characteristic hinge diverse from a proline in KIF13B to a long flexible linker in KIF1A.The functio...
关键词:intracellular transport molecular motor kinesin-3 neck hinge processive movement 
Kinesin 26B modulates M2 polarization of macrophage by activating cancer-associated fibroblasts to aggravate gastric cancer occurrence and metastasis
《World Journal of Gastroenterology》2024年第20期2689-2708,共20页Lian-Meng Huang Ming-Jin Zhang 
BACKGROUND The regulatory effects of KIF26B on gastric cancer(GC)have been confirmed,but the specific mechanism still needs further exploration.Pan-cancer analysis shows that the KIF26B expression is highly related to...
关键词:METASTASIS INVASION MACROPHAGE 
Origin of tradeoff between movement velocity and attachment duration of kinesin motor on a microtubule
《Chinese Physics B》2024年第2期557-566,共10页刘玉颖 张志强 
Kinesin-1 motor protein is a homodimer containing two identical motor domains connected by a common long coiledcoil stalk via two flexible neck linkers. The motor can step on a microtubule with a velocity of about 1 ...
关键词:motor protein VELOCITY detachment time PROCESSIVITY 
Connecting neurodevelopment to neurodegeneration:a spotlight on the role of kinesin superfamily protein 2A(KIF2A)被引量:1
《Neural Regeneration Research》2024年第2期375-379,共5页Nuria Ruiz-Reig Janne Hakanen Fadel Tissir 
Fund for Scientific Research(FNRS)PDR T0236.20;FNRS-Exellence of Science 30913351;FNRS CDR J.0175.23(to FT)。
Microtubules play a central role in cytoskeletal changes during neuronal development and maintenance.Microtubule dynamics is essential to polarity and shape transitions underlying neural cell division,differentiation,...
关键词:brain disorders cortical malformations KINESIN MICROTUBULES NEURODEGENERATION NEURODEVELOPMENT 
Kinesin-microtubule interaction reveals the mechanism of kinesin-1 for discriminating the binding site on microtubule
《Chinese Physics B》2023年第10期738-748,共11页耿轶钊 鲁丽爱 贾宁 张冰冰 纪青 
supported by the Natural Science Foundation of Hebei Province of China(Grant No.A2020202007);the National Natural Science Foundation of China(Grant No.11605038)。
Microtubule catalyzes the mechanochemical cycle of kinesin,a kind of molecular motor,through its crucial roles in kinesin's gating,ATPase and force-generation process.These functions of microtubule are realized throug...
关键词:KINESIN TUBULIN MICROTUBULE molecular dynamics simulation 
KIF23过表达预示甲状腺乳头状癌患者预后不良
《南开大学学报(自然科学版)》2023年第2期53-60,共8页张文瑞 王虹喜 霍磊 
Supported by the Green Seedling Project of the Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine(QMJH202001)。
甲状腺乳头状癌(PTC)的发病率正在迅速增加,需要寻找新的生物标志物用于治疗和预后.运动蛋白家族在肿瘤发生和发展中发挥重要作用,是多种肿瘤的治疗靶点.基于GEPIA数据库初步分析KIF23对PTC预后的影响.与正常组织相比,显示KIF23基因在...
关键词:Kinesin家族成员23(KIF23) 甲状腺乳头状癌(PTC) 生物标志物 预后 
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