Oxygen nanobubbles of ICG dimers achieve self-cascade photothermal and photodynamic therapy for hypoxia-reversible tumor treatment  

作　　者：Xiang Sun Zheng Zhang Moran Wang Yuqin Chen Xiang Meng Wenjun Zhao Juan Jin Wanghanqi Yang Chengwan Xia Yuxin Wang Shengliang Li Bin Huang Ning Gu 

机构地区：[1]Key Laboratory for Bio-Electromagnetic Environment and Advanced Medical Theranostics,School of Biomedical Engineering and Informatics,Nanjing Medical University,Nanjing 210029,China [2]Department of Oral and Maxillofacial Trauma Orthognathic Plastic Surgery,Nanjing Stomatological Hospital,Research Institute of Stomatology,Medical School of Nanjing University,Nanjing 210093,China [3]College of Pharmaceutical Sciences,Soochow University,Suzhou 215123,China [4]Nanjing Key Laboratory for Cardiovascular Information and Health,Engineering Medicine Institute of Clinical Medicine,Nanjing Drum Tower Hospital,Medical School of Nanjing University,Nanjing 210008,China

出　　处：《Nano Research》2025年第4期325-336,共12页纳米研究(英文版)

基　　金：supported by the National Key R&D Program of China(No.2023YFF0713600);the National Natural Science Foundation of China(Nos.62375138,and 52173135);the National Natural Science Innovative Research Group Project(No.61821002);the Frontier Fundamental Research Program of Jiangsu Province for Leading Technology(No.BK 20222002);the Natural Science Foundation of Jiangsu Province(No.BK 20231523);Jiangsu Specially Appointed Professorship.

摘　　要：Simultaneous photothermal and photodynamic therapies(PTT and PDT)hold great promise for noninvasive tumor therapy.However,effective regulation of PTT and PDT with optimal synergistic effects remains a challenge.To date,there are only a few synergistic PTT and PDT methods with suitable collaborative effects due to the rarity of efficient nanoplatforms with good cascading properties.To overcome this limitation,a proof-of-concept of self-cascade PTT and PDT was developed for hypoxia-reversible tumor therapy.With the assembly of dimeric indocyanine green(DICG)with oxygen nanobubbles(O_(2)-NBs),DICG/O_(2)-NBs typically exhibit J-aggregates for significant PTT effects,with a high photothermal conversion efficiency of 51.45% under 880 nm light irradiation.Interestingly,the PTT performance of DICG/O_(2)-NBs can switch J-aggregates of DICG into DICG monomers with efficient O_(2) gas liberation,while producing hydroxyl radicals for type Ⅰ PDT.Additionally,the evolved DICG monomer reacts with the released O_(2) to generate plenty of 1O_(2) for efficient type Ⅱ PDT.With these advantages,the cascaded nanoplatform achieves good tumor targeting and biocompatibility,and thus has high tumor inhibition of 94.26%,with an obvious ability to reverse hypoxia.This work demonstrates the efficiency of self-cascade PTT and PDT nanomedicine for high-performance hypoxia-reversible tumor ablation,thus providing a new approach for the development of cascading phototheranostics in vivo.

关 键 词：indocyanine green(ICG)dimer oxygen nanobubble J-aggregate self-cascade photothermal therapies(PTT) photodynamic therapies(PDT) 

分 类 号：R730.5[医药卫生—肿瘤]