Delivery of therapeutic oligonucleotides in nanoscale  

作　　者：Lei Wu Wenhui Zhou Lihua Lin Anhong Chen Jing Feng Xiangmeng Qu Hongbo Zhang Jun Yue 

机构地区：[1]School of Biomedical Engineering,Sun Yat-sen University,Guangzhou,510006,Guangdong,China [2]Pharmaceutical Sciences Laboratory and Turku Bioscience Centre,Åbo Akademi University,Turku,20520,Finland [3]Southern Medical University Affiliated Fengxian Hospital,Shanghai,201499,China

出　　处：《Bioactive Materials》2022年第1期292-323,共32页生物活性材料（英文）

基　　金：This work was financially supported by the Natural Science Foundation of China(81871472);Natural Science Foundation of Guangdong Province(Project No.2019A1515010696 and 2021A1515012333);Shenzhen Municipal Science,Technology and Innovation Commission(Project No.JCYJ20190807163003704);“100 Talents Program”of the start-up foundation from Sun Yat-sen University,Academy of Finland(328933)and Sigrid Jus´elius Foundation.

摘　　要：Therapeutic oligonucleotides(TOs)represent one of the most promising drug candidates in the targeted cancer treatment due to their high specificity and capability of modulating cellular pathways that are not readily druggable.However,efficiently delivering of TOs to cancer cellular targets is still the biggest challenge in promoting their clinical translations.Emerging as a significant drug delivery vector,nanoparticles(NPs)can not only protect TOs from nuclease degradation and enhance their tumor accumulation,but also can improve the cell uptake efficiency of TOs as well as the following endosomal escape to increase the therapeutic index.Furthermore,targeted and on-demand drug release of TOs can also be approached to minimize the risk of toxicity towards normal tissues using stimuli-responsive NPs.In the past decades,remarkable progresses have been made on the TOs delivery based on various NPs with specific purposes.In this review,we will first give a brief introduction on the basis of TOs as well as the action mechanisms of several typical TOs,and then describe the obstacles that prevent the clinical translation of TOs,followed by a comprehensive overview of the recent progresses on TOs delivery based on several various types of nanocarriers containing lipid-based nanoparticles,polymeric nanoparticles,gold nanoparticles,porous nanoparticles,DNA/RNA nanoassembly,extracellular vesicles,and imaging-guided drug delivery nanoparticles.

关 键 词：Therapeutic oligonucleotides NANOPARTICLES ANTI-CANCER Targeted delivery Clinical translation 

分 类 号：R318[医药卫生—生物医学工程] TB3[医药卫生—基础医学]