APTAMER

作品数：238被引量：376H指数：8
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相关机构：湖南大学军事医学科学院华中科技大学武汉大学更多>>
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Assessing traditional Chinese medicine from a molecular perspective
《Journal of Traditional Chinese Medical Sciences》2025年第1期3-9,共7页Minhui Su Wenxi Wang Xudong Sun Lihong Li Weihong Tan 
supported by the National Natural Science Foundation of China(T2188102);Hangzhou Institute of Medicine(2024ZZBS02,Hangzhou,China).
Molecular medicine,which delves into the intricacies of biomolecular structure,function,and role,is pivotal for advancing precise diagnostics and personalized treatment.Nucleic acids,a class of star functional molecul...
关键词：Molecular medicine Nucleic acid molecular medicine APTAMER Traditional Chinese medicine 
Single-Round Circular Aptamer Discovery Using Bioinspired Magnetosome-Like Magnetic Chain Cross-Linked Graphene Oxide
《Research》2025年第1期23-34,共12页Lili Yao Junmei Feng Yuefei Zhou Shengjie Gao Shuai Liu Hao Qu Yu Mao Lei Zheng 
supported by the National Natural Science Foundation of China(22104028,32072306,and U23A20265).
Circular aptamers are promising candidates for analytical and therapeutic applications due to their enhanced biological and structural stability.However,the process of circular aptamer selection remains a great challe...
关键词：lipopolysaccharide analytical therapeutic applications magnetosome magnetic chain graphene oxide high affinity aptamer selection protein targets single round circular aptamer discovery circular aptamers 
A Novel Composite of Aptamer-Based Ti_(3)C_(2)T_(x)and Molecularly Imprinted Polymer with Double Recognition Property for Sensitive Electrochemical Detection of Ofloxacin
《Journal of Analysis and Testing》2025年第1期109-117,共9页Hanxing Yang Wenting Wang Yanbo Zeng Rong Tang Huixiang Yan Yiwen Yang Hailong Wang Jianbo Wang Longhua Guo Jianguo Xu Lei Li 
supported by the National Natural Science Foundation of China(21507041,21677060);the Zhejiang Province Public Welfare Technology Application Research Project(LGF21B050004);Scientific Research Fund of Zhejiang Provincial Education Department(Y202352065);Jiaxing Municipal Public Welfare Research Project(2022AY10015)。
A novel composite of aptamer-based Ti_(3)C_(2)T_(x)and molecularly imprinted polymer(Apt-Ti_(3)C_(2)T_(x)-MIP)with double recognition property was prepared for sensitive electrochemical detection of ofloxacin(OFL).Fir...
关键词：Ti_(3)C_(2)T_(x) APTAMER Molecular imprinting Double recognition Electrochemical sensor OFLOXACIN 
DNA walker induced“signal on”fluorescence aptasensor strategy for rapid and sensitive detection of extracellular vesicles in gastric cancer
《Chinese Chemical Letters》2025年第2期300-303,共4页Gaojian Yang Zhiyang Li Rabia Usman Zhu Chen Yuan Liu Song Li Hui Chen Yan Deng Yile Fang Nongyue He 
supported financially by the National Natural Science Foundation of China(NSFC,Nos.62071119 and 62075098);the National Key Research and Development Program of China(Nos.2017YFA0205301 and 2018YFC1602905)。
The extracellular vesicles show great potential as a noninvasive biomarker for the early detection of cancer.Hence,there is an urgent requirement to create biosensors that are time-saving,simple,and easily scalable in...
关键词：Extracellular vesicles APTAMER Streptavidin magnetic beads Nt.BbvCI Detection 
Tumor acidic microenvironment activatable DNA nanostructure for precise cancer cell targeting and inhibition
《Chinese Chemical Letters》2025年第1期415-419,共5页Yanfei Liu Yaqin Hu Yifu Tan Qiwen Chen Zhenbao Liu 
funded by the National Natural Science Foundation of China(No.32271464);the Hunan Provincial Natural Science Foundation for Distinguished Young Scholars(No.2022JJ10086);the Innovation-Driven Project of Central South University(No.2020CX048);Hunan Provincial High-Level Health Talents(No.20240304088);Fund of the Hunan Provincial Natural Science Foundation and the Hunan Medical Products Administration(No.2023JJ60501)。
Precise tumor targeting and therapy is a major trend in cancer treatment.Herein,we designed a tumor acidic microenvironment activatable drug loaded DNA nanostructure,in which,we made a clever use of the sequences of A...
关键词：APTAMER I-MOTIF DNA nanostructure Logic gate Drug delivery system 
Aptamer-drug conjugates-loaded bacteria for pancreatic cancer synergistic therapy
《Signal Transduction and Targeted Therapy》2024年第11期5200-5216,共17页Yu Xiao Tao Pan Wuren Da Yuanding Liu Shuangya Chen Daiquan Chen Keying Liu Yihan Zheng Daolong Xie Yuan Gao Haiyan Xu Yang Sun Weihong Tan 
the China Postdoctoral Science Foundation(Certificate Number:2023M742348);the Fundamental Research Funds for the Central Universities(2020JCPT02);the“Innovation Research Team of High-Level of Local Universities in Shanghai”;the National Key Research and Development Program of China(2023YFC3405100).
Pancreatic cancer is one of the most malignant tumors with the highest mortality rates,and it currently lacks effective drugs.Aptamer-drug conjugates(ApDC),as a form of nucleic acid drug,show great potential in cancer...
关键词：DRUGS SPECIFICITY SYNERGISTIC 
Electrochemical aptasensor based on black phosphorus-porous graphene nanocomposites for high-performance detection of Hg^(2+)
《Chinese Chemical Letters》2024年第11期372-377,共6页Jie Zhou Chuanxiang Zhang Changchun Hu Shuo Li Yuan Liu Zhu Chen Song Li Hui Chen Rokayya Sami Yan Deng 
financially supported by the NSF of China(No.61871180);2022 Special Project for the Construction of Innovative Provinces to Fight the COVID-19 Outbreak(No.2022SK2115);Natural Science Foundation of Hunan Province of China(Nos.2022JJ30230,2021JJ30213);the Deanship of Scientific Research,Taif University。
A novel approach was developed to fabricate a label-free electrochemical aptasensor for specific detection of mercury ions(Hg^(2+)).This involved modifying polylysine(PLL)-coated black phosphorus-porous graphene(BP-PG...
关键词：Hg^(2+) Electrochemical sensor Black phosphorus-porous graphene APTAMER AuNPs 
Computational Simulation of Aptamer-target Binding Mechanisms
《中国生物化学与分子生物学报》2024年第11期1550-1562,共13页YANG Yuan-Yuan XU Fei WU Xiu-Xiu 
国家自然科学基金(No.32072312)资助。
Aptamers are a type of single-chain oligonucleotide that can combine with a specific target.Due to their simple preparation,easy modification,stable structure and reusability,aptamers have been widely applied as bioch...
关键词：computational simulation APTAMER TARGET binding mechanism intermolecular forces 
Multifunctional Ce-MOF@PdNPs with colorimetric fluorescent electrochemical activity for ultrasensitive and accurate detection of diethylstilbestrol
《Nano Research》2024年第11期9990-9998,共9页Mingyue Ye Tingting Su Jin Li Xiaowan Chen Dichen Ying Shijia Wu Zhouping Wang Nuo Duan 
supported by Jiangsu Agriculture Science and Technology Innovation Fund(No.CX(22)3006);National Natural Science Foundation of China(Nos.32272449 and 32072310);the Fundamental Research Funds for the Central Universities(No.JUSRP622025);Collaborative innovation center of food safety and quality control in Jiangsu Province.
The development of biosensors is gaining tremendous attention in various fields due to their extraordinary advantages, however, their sensitivity and accuracy are still challenging. Herein, we proposed a novel multifu...
关键词：cerium-based materials Pd nanoparticles(PdNPs) APTAMER colorimetric/fluorescence/electrochemical signal amplification 
An aptamer-driven DNA nanodevice for improved delivery of synthetic immunostimulants
《Nano Research》2024年第10期9078-9083,共6页Dejie Lu Zhenghan Di Lele Li Jian Zhao Li Zheng 
supported financially by the National Natural Science Foundation of China(Nos.T2322005 and 32101156);Youth Innovation Promotion Association CAS.
Efficient delivery of therapeutics to immune cells remains a formidable challenge for cancer immunotherapy.In this work,we demonstrate that an aptamer-driven DNA nanodevice,constructed through linkage of a synthetic i...
关键词：APTAMER immunostimulatory oligonucleotides DNA nanodevice tumor-associated macrophages cancer therapy 
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