云南高校图书馆联盟文献共享服务平台- I-MOTIF

I-MOTIF: 作品数：23被引量：15H指数：2; 导出分析报告; 相关领域：理学生物学更多>>; 相关作者：许文菊李涛国新华胡宇芳马少华更多>>; 相关机构：西南大学湖南大学吉林大学中国科学院更多>>; 相关期刊：《Science China Chemistry》《广东化工》《分析测试学报》《分析化学》更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划山西省回国留学人员科研经费资助项目国家科技重大专项更多>>

i-Motif DNA在纳米生物技术与疾病诊疗方面的应用: 《广东化工》2025年第3期69-72,共4页高安琪罗腾硕程明攀; DNA除了具有典型的右手双螺旋结构外,还具有多种多样的二级结构。i-Motif DNA是富含胞嘧啶碱基(C)的序列,以半质子化的C·C^(+)碱基对为基础形成的特殊二级结构。其广泛存在于染色体端粒末端和基因启动子区域,并与多种癌症的发生相关,...; 关键词：i-Motif DNA 癌症治疗生物分析药物释放

Tumor acidic microenvironment activatable DNA nanostructure for precise cancer cell targeting and inhibition: 《Chinese Chemical Letters》2025年第1期415-419,共5页Yanfei Liu Yaqin Hu Yifu Tan Qiwen Chen Zhenbao Liu; funded by the National Natural Science Foundation of China(No.32271464);the Hunan Provincial Natural Science Foundation for Distinguished Young Scholars(No.2022JJ10086);the Innovation-Driven Project of Central South University(No.2020CX048);Hunan Provincial High-Level Health Talents(No.20240304088);Fund of the Hunan Provincial Natural Science Foundation and the Hunan Medical Products Administration(No.2023JJ60501)。; Precise tumor targeting and therapy is a major trend in cancer treatment.Herein,we designed a tumor acidic microenvironment activatable drug loaded DNA nanostructure,in which,we made a clever use of the sequences of A...; 关键词：APTAMER I-MOTIF DNA nanostructure Logic gate Drug delivery system

Light-Mediated Spatiotemporally Dynamic Assembly of DNA Nanostructures in Living Cells Regulates Autophagy: 《CCS Chemistry》2024年第6期1557-1570,共14页Rui Zhang Pin Hu Yuwei Xu Ziqing Wang Dayong Yang Chi Yao; supported by the National Natural Science Foundation of China(grant nos.22225505,22322407,and 22174097);D.Y.thanks Fudan University Ruiqing Education Funding.; The assembly of exogenous artificial architectures inside cells can regulate a series of biological events,which heavily relies on the development of spatiotemporally controlled molecular assembly systems.We herein re...; 关键词：DNA nanotechnology DNA hydrogel SELF-ASSEMBLY AUTOPHAGY I-MOTIF

人端粒i-motif:结构、识别和生物学功能: 《中国生物化学与分子生物学报》2023年第11期1524-1533,共10页黄钧柳张昀崔晓杰; 民族地区生态环境国家民委重点实验室(中央民族大学)自主课题资助(No.KLEEMA202201)。; 人端粒i-motif是由人端粒末端富含胞嘧啶(cytosine,C)的核酸序列形成的特殊高级结构,在端粒重复序列RNA(telomeric repeat-containing RNA,TERRA)转录调控、端粒功能维持和端粒酶活性抑制等方面发挥重要作用。端粒i-motif与多种癌症的...; 关键词：I-MOTIF 人端粒结构配体识别癌症治疗

Polydopamine-coated i-motif DNA/Gold nanoplatforms for synergistic photothermal-chemotherapy: 《Asian Journal of Pharmaceutical Sciences》2023年第2期49-60,共12页Bo Chen Lan Mei Rangrang Fan Di Chuan Yangmei Ren Min Mu Haifeng Chen Bingwen Zou Gang Guo; This work was financially supported by National Natural Sciences Foundation of China(31971308 and 82102767);National S&T Major Project(2019ZX09301-147);Sichuan Science and Technology Program(2021YFS0081);Luzhou Science and Technology Plan(2018CDLZ-10).; The combination of photothermal therapywith chemotherapy has gradually developed into promising cancer therapy.Here,a synergistic photothermal-chemotherapy nanoplatform based on polydopamine(PDA)-coated gold nanoparti...; 关键词：Gold nanoparticles POLYDOPAMINE I-MOTIF AS1411 aptamer Photothermal-chemotherapy

Engineering DNA quadruplexes in DNA nanostructures for biosensor construction: 《Nano Research》2022年第4期3504-3513,共10页Jingxin Liu Li Yan Shiliang He Junqing Hu; This work was financially supported by the National Natural Science Foundation of China(Nos.51972055,81803480,and 21902101);the Shenzhen Science and Technology Research Project(No.JCYJ20180508152903208);the Shenzhen Pengcheng Scholar Program,and Shenzhen Bay Laboratory Open Fund(No.SZBL2020090501002).; DNA quadruplexes are nucleic acid conformations comprised of four strands.They are prevalent in human genomes and increasing efforts are being directed toward their engineering.Taking advantage of the programmability ...; 关键词：G-QUADRUPLEX I-MOTIF DNA nanotechnology BIOSENSOR

基于i-motif的生物医学应用纳米系统:pH成像、药物控释和肿瘤诊疗: 《分析测试学报》2022年第4期486-497,共12页马文杰黄金程洪贾瑞晨陈彪孙欢欢吴宇辰何晓晓王柯敏; the Natural Science Foundation of China(21735002,21874035,21675046,22174044);Postgraduate Scientific Research Innovation Project of Hunan Province(CX20210396)。; I-motif作为一种新型pH敏感元件,因其在不同pH条件下可以进行快速的构象转变,以及具有自动化合成、优异的生物相容性和灵活的功能化整合等优点,在生物医学领域引起了广泛的关注和研究热潮。该文介绍了i-motif的基本性能,综述了基于i-mo...; 关键词：I-MOTIF pH成像 pH控制的药物释放 pH响应型肿瘤诊疗

pH-Responsive Magnetic I-Motif Container Coupled with DNA Walker for Construction of Dual-Signal Electrochemical Biosensor被引量：1: 《Journal of Analysis and Testing》2022年第1期3-10,共8页Xin-Yan Wang Yuanfang Li Shuzhen Lv Sai Bi; supported by the National Natural Science Foundation of China(22076087);the Special Funds of the Taishan Scholar Program of Shandong Province(tsqn20161028);the Science Foundation for Distinguished Young Scholars of Shandong Province(ZR2020JQ08);the Youth Innovation Technology Program of Shandong Province(2019KJC029);the Collaborative Innovation Program of Jinan(2018GXRC033).; Herein,a dual-signal electrochemical biosensor has been developed by self-assembly of pH-activatable i-motif probes on magnetic microparticles(MMPs)coupled with DNA walker for signal amplification.In this study,the cy...; 关键词：Dual-signal electrochemical biosensor pH I-MOTIF DNA walker Signal amplification

Synchronous conjugation of i-motif DNA and therapeutic siRNA on the vertexes of tetrahedral DNA nanocages for efficient gene silence被引量：3: 《Acta Pharmaceutica Sinica B》2021年第10期3286-3296,共11页Xiu Han Xiang Xu Ziheng Wu Zhenghong Wu Xiaole Qi; supported by Double First-Class Innovation Team of China Pharmaceutical University(CPU2018GY40,China);National Mega-project for Innovative Drugs(2019ZX09721001,China)。; The functionality of DNA biomacromolecules has been widely excavated,as therapeutic drugs,carriers,and functionalized modification derivatives.In this study,we developed a series of DNA tetrahedron nanocages(Td),via s...; 关键词：I-MOTIF SIRNA Gene delivery DNA tetrahedron Endosomal escape Cancer Gene silence Biocompatibility

解聚集诱导发射探针用于人端粒i-Motif二聚体与单体的选择性识别被引量：1: 《分析化学》2021年第6期992-998,共7页曾瑞迪杨通陈佳汇王丹丹周小顺邵勇; 浙江省自然科学基金重点项目(No.LZ20B050001);浙江省万人计划项目(No.2020R52022);国家自然科学基金项目(No.21675142);国家级大学生创新创业计划项目(No.201910345027);浙江师范大学自主设计科研项目(No.2020ZS0304)资助。; 由于具有重要的生物活性,并在生物传感器和材料化学等领域广泛应用,i-motif结构开关及识别引起越来越多的关注。分子内i-motif多聚体具有多个重复结构单元,其与i-motif单体的周围环境存在差异。虽然有关i-motif单体的探针识别已有报道,...; 关键词：分子内i-motif二聚体 i-motif单体金丝桃素荧光探针选择性识别

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