基于i-motif的生物医学应用纳米系统:pH成像、药物控释和肿瘤诊疗  

I-Motif-based Nanosystems for Biomedical Appli⁃cations:pH Imaging,Drugs Controlled Release and Tumor Theranostics

作　　者：马文杰 黄金 程洪 贾瑞晨 陈彪 孙欢欢 吴宇辰 何晓晓[1,2] 王柯敏[2] MA Wen-jie;HUANG Jin;CHENG Hong;JIA Rui-chen;CHEN Biao;SUN Huan-huan;WU Yu-chen;HE Xiao-xiao;WANG Ke-min(College of Biology,Hunan University,Changsha 410082,China;State Key Laboratory of Chemo/Biosensing and Chemometrics,College of Chemistry and Chemical Engineering,Hunan University,Key Laboratory for Bio-nanotechnology and Molecule Engineering of Hunan Province,Changsha 410082,China)

机构地区：[1]湖南大学生物学院,湖南长沙410082 [2]湖南大学化学化工学院,化学/生物传感与化学计量学国家重点实验室,湖南省生物纳米技术与分子工程重点实验室,湖南长沙410082

出　　处：《分析测试学报》2022年第4期486-497,共12页Journal of Instrumental Analysis

基　　金：the Natural Science Foundation of China(21735002,21874035,21675046,22174044);Postgraduate Scientific Research Innovation Project of Hunan Province(CX20210396)。

摘　　要：I-motif作为一种新型pH敏感元件,因其在不同pH条件下可以进行快速的构象转变,以及具有自动化合成、优异的生物相容性和灵活的功能化整合等优点,在生物医学领域引起了广泛的关注和研究热潮。该文介绍了i-motif的基本性能,综述了基于i-motif的纳米系统在细胞pH成像、pH控制的药物释放和pH响应型肿瘤诊疗一体化等生物医学领域的应用研究进展,总结了基于i-motif的纳米系统在生物医学应用中面临的挑战,并展望了基于i-motif的纳米系统在精准医学中的应用前景。I-motif,as a novel pH-sensitive element,has attracted extensive attention and research upsurge in the field of biomedicine due to its ability of fast conformation alteration at different pH conditions,as well as the advantages of au⁃tomatic synthesis,excellent biocompatibility and flexible functional integration.In this review,the basic performances of i-motif are firstly described.Then,the applications of i-motif-based nanosystems in biomedical field are reviewed from three aspects of cellular pH imaging,pH-controlled drugs release and pH-responsive tumor theranostics applica⁃tions.Finally,some of the current challenges of the i-motif-based nanosystems for the biomedical applications are point⁃ed out,and an insight into the future prospects of i-motif-based nanosystems for precision medicine is provided.

关 键 词：I-MOTIF pH成像 pH控制的药物释放 pH响应型肿瘤诊疗 

分 类 号：O657.3[理学—分析化学] G353.11[理学—化学]