Polydopamine-coated i-motif DNA/Gold nanoplatforms for synergistic photothermal-chemotherapy  

作　　者：Bo Chen Lan Mei Rangrang Fan Di Chuan Yangmei Ren Min Mu Haifeng Chen Bingwen Zou Gang Guo 

机构地区：[1]State Key Laboratory of Biotherapy and Cancer Center,West China Hospital,Sichuan University,Chengdu 610041,China [2]Department of Neurosurgery,West China Hospital,Sichuan University,Chengdu 610041,China [3]Department of Thoracic Oncology and Department of Radiation Oncology,Cancer Center,West China Hospital,Sichuan University,Chengdu 610041,China

出　　处：《Asian Journal of Pharmaceutical Sciences》2023年第2期49-60,共12页亚洲药物制剂科学（英文）

基　　金：This work was financially supported by National Natural Sciences Foundation of China(31971308 and 82102767);National S&T Major Project(2019ZX09301-147);Sichuan Science and Technology Program(2021YFS0081);Luzhou Science and Technology Plan(2018CDLZ-10).

摘　　要：The combination of photothermal therapywith chemotherapy has gradually developed into promising cancer therapy.Here,a synergistic photothermal-chemotherapy nanoplatform based on polydopamine(PDA)-coated gold nanoparticles(AuNPs)were facilely achieved via the in situ polymerization of dopamine(DA)on the surface of AuNPs.This nanoplatform exhibited augmented photothermal conversion efficiency and enhanced colloidal stability in comparison with uncoated PDA shell AuNPs.The i-motif DNA nanostructure was assembled on PDA-coated AuNPs,which could be transformed into a C-quadruplex structure under an acidic environment,showing a characteristic pH response.The PDA shell served as a linker between the AuNPs and the i-motif DNA nanostructure.To enhance the specific cellular uptake,the AS1411 aptamer was introduced to the DNA nanostructure employed as a targeting ligand.In addition,Dox-loaded NPs(DAu@PDA-AS141)showed the pH/photothermal-responsive release of Dox.The photothermal effect of DAu@PDA-AS141 elicited excellent photothermal performance and efficient cancer cell inhibition under 808 nm near-infrared(NIR)irradiation.Overall,these results demonstrate that the DAu@PDA-AS141 nanoplatform shows great potential in synergistic photothermal-chemotherapy.

关 键 词：Gold nanoparticles POLYDOPAMINE I-MOTIF AS1411 aptamer Photothermal-chemotherapy 

分 类 号：TB383.1[一般工业技术—材料科学与工程] R730.5[医药卫生—肿瘤]