New insights into the therapeutic approaches for the treatment of tauopathies  

作　　者：Himanshi Singh Asmita Das Mohammad Moshahid Khan Tayebeh Pourmotabbed 

机构地区：[1]Department of Microbiology,Immunology and Biochemistry,University of Tennessee Health Science Center,Memphis,TN,USA [2]Department of Biotechnology,Delhi Technological University,Shahbad Daulatpur,Delhi,India [3]Department of Neurology,College of Medicine,University of Tennessee Health Science Center,Memphis,TN,USA [4]Neuroscience Institute,University of Tennessee Health Science Center,Memphis,TN,USA [5]Center for Muscle,Metabolism and Neuropathology,Division of Regenerative and Rehabilitation Sciences and Department of Physical Therapy,College of Health Professions,University of Tennessee Health Science Center,Memphis,TN,USA

出　　处：《Neural Regeneration Research》2024年第5期1020-1026,共7页中国神经再生研究（英文版）

基　　金：supported by National Institute of Health grant number R03AG075597(to MMK and TP);Department of Defense Award Number HT9425-23-1-0043(to MMK).

摘　　要：Tauopathies are a group of neurological disorders,including Alzheimer’s disease and frontotemporal dementia,which involve progressive neurodegeneration,cognitive deficits,and aberrant tau protein accumulation.The development of tauopathies cannot currently be stopped or slowed down by treatment measures.Given the significant contribution of tau burden in primary tauopathies and the strong association between pathogenic tau accumulation and cognitive deficits,there has been a lot of interest in creating therapies that can alleviate tau pathology and render neuroprotective effects.Recently,small molecules,immunotherapies,and gene therapy have been used to reduce the pathological tau burden and prevent neurodegeneration in animal models of tauopathies.However,the major pitfall of the current therapeutic approach is the difficulty of drugs and gene-targeting modalities to cross the blood-brain barrier and their unintended side effects.In this review,the current therapeutic strategies used for tauopathies including the use of oligonucleotide-based gene therapy approaches that have shown a promising result for the treatment of tauopathies and Alzheimer’s disease in preclinical animal models,have been discussed.

关 键 词：DEMENTIA gene therapies IMMUNOTHERAPY NEURODEGENERATION OLIGONUCLEOTIDES tau TAUOPATHIES THERAPIES 

分 类 号：R741[医药卫生—神经病学与精神病学]