Self-assembly of tau fragments as a key pathologic event in tauopathies  

作　　者：Ly Thi Huong Luu Le Jung Hoon Lee Min Jae Lee 

机构地区：[1]Department of Biochemistry and Molecular Biology,Seoul National University College of Medicine,Seoul,Korea

出　　处：《Neural Regeneration Research》2024年第12期2565-2566,共2页中国神经再生研究（英文版）

基　　金：supported by grants from the National Research Foundation of Korea (2021 R1A2C2008023,2020R1A5A 1019023;RS-2023-00261784 to MJL;2021R1/1A1A 01051245to JHL)。

摘　　要：Tau protein is encoded by the microtubuleassociated protein tau(MAPT)gene and stabilizes microtubules in the neurons.Tau has unique biophysical properties that make it both highly water-soluble and positively charged.Although tau is an intrinsically disordered protein lacking defined secondary structures,it can acquire highly organized-sheet structures and stack into a filamentous inclusion such as a paired helical filament(PHF).

关 键 词：TAU PATHOLOGIC assembly 

分 类 号：R741[医药卫生—神经病学与精神病学]