Overlaps and divergences between tauopathies and synucleinopathies:a duet of neurodegeneration  

作　　者：Wen Li Jia-Yi Li 

机构地区：[1]Health Sciences Institute,Key Laboratory of Major Chronic Diseases of Nervous System of Liaoning Province,China Medical University,Shenyang 110122,China [2]Neural Plasticity and Repair Unit,Department of Experimental Medical Science,Wallenberg Neuroscience Center,Lund University,BMC A10,22184 Lund,Sweden

出　　处：《Translational Neurodegeneration》2024年第1期861-873,共13页转化神经变性病(英文)

基　　金：supported by the National Natural Science Foundation of China(82371273,81430025,U1801681 to J-Y.L.and W.L.);the Key Field Research Development Program of Guangdong Province(2018B030337001);the Swedish Research Council(2019-01551,2023-02216);ParkinsonFonden(1351/21,1421/22,1494/23);the Strategic Research Area Multipark(Multidisciplinary research in Parkinson’s disease at Lund University);Hjarnfonden(FO2022-0282,FO2023-0397,PS2018-0062);Svenska Sällskapet för Medicinsk Forskning(SSMF,P18-0194).

摘　　要：Proteinopathy,defined as the abnormal accumulation of proteins that eventually leads to cell death,is one of the most significant pathological features of neurodegenerative diseases.Tauopathies,represented by Alzheimer’s disease(AD),and synucleinopathies,represented by Parkinson’s disease(PD),show similarities in multiple aspects.AD manifests extrapyramidal symptoms while dementia is also a major sign of advanced PD.We and other researchers have sequentially shown the cross-seeding phenomenon ofα-synuclein(α-syn)and tau,reinforcing pathologies between synucleinopathies and tauopathies.The highly overlapping clinical and pathological features imply shared pathogenic mechanisms between the two groups of disease.The diagnostic and therapeutic strategies seemingly appropriate for one distinct neurodegenerative disease may also apply to a broader spectrum.Therefore,a clear understanding of the overlaps and divergences between tauopathy and synucleinopathy is critical for unraveling the nature of the complicated associations among neurodegenerative diseases.In this review,we discuss the shared and diverse characteristics of tauopathies and synucleinopathies from aspects of genetic causes,clinical manifestations,pathological progression and potential common therapeutic approaches targeting the pathology,in the aim to provide a timely update for setting the scheme of disease classification and provide novel insights into the therapeutic development for neurodegenerative diseases.

关 键 词：TAUOPATHY SYNUCLEINOPATHY Tau α-Synuclein NEURODEGENERATION 

分 类 号：R74[医药卫生—神经病学与精神病学]