SYNUCLEINOPATHY

作品数：9被引量：9H指数：1
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相关领域：医药卫生更多>>
相关作者：黄越王维治更多>>
相关机构：哈尔滨医科大学附属第二医院更多>>
相关期刊：《Neuroimmunology and Neuroinflammation》《Journal of Biomedical Research》《Neural Regeneration Research》《Translational Neurodegeneration》更多>>
相关基金：国家自然科学基金广东省自然科学基金更多>>
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Overlaps and divergences between tauopathies and synucleinopathies:a duet of neurodegeneration
《Translational Neurodegeneration》2024年第1期861-873,共13页Wen Li Jia-Yi Li 
supported by the National Natural Science Foundation of China(82371273,81430025,U1801681 to J-Y.L.and W.L.);the Key Field Research Development Program of Guangdong Province(2018B030337001);the Swedish Research Council(2019-01551,2023-02216);ParkinsonFonden(1351/21,1421/22,1494/23);the Strategic Research Area Multipark(Multidisciplinary research in Parkinson’s disease at Lund University);Hjarnfonden(FO2022-0282,FO2023-0397,PS2018-0062);Svenska Sällskapet för Medicinsk Forskning(SSMF,P18-0194).
Proteinopathy,defined as the abnormal accumulation of proteins that eventually leads to cell death,is one of the most significant pathological features of neurodegenerative diseases.Tauopathies,represented by Alzheime...
关键词：TAUOPATHY SYNUCLEINOPATHY Tau α-Synuclein NEURODEGENERATION 
Profiling neuroprotective potential of trehalose in animal models of neurodegenerative diseases:a systematic review
《Neural Regeneration Research》2023年第6期1179-1185,共7页Kah Hui Yap Shahrul Azmin Suzana Makpol Hanafi Ahmad Damanhuri Muzaimi Mustapha Jemaima Che Hamzah Norlinah Mohamed Ibrahim 
supported by Dana Impak Perdana Grant(DIP-2019-007)received by NMI from Universiti Kebangsaan Malaysia.
Trehalose,a unique nonreducing crystalline disaccharide,is a potential disease-modifying treatment for neurodegenerative diseases associated with protein misfolding and aggregation due to aging,intrinsic mutations,or ...
关键词：amyotrophic lateral sclerosis autophagy neurodegenerative disease NEUROINFLAMMATION polyglutamine tract protein refolding spinocerebellar ataxia SYNUCLEINOPATHY tau pathology TREHALOSE 
Reciprocal effects of alpha-synuclein aggregation and lysosomal homeostasis in synucleinopathy models被引量：1
《Translational Neurodegeneration》2023年第1期479-499,共21页Alice Drobny Fanni Annamária Boros Denise Balta Susy Prieto Huarcaya Deniz Caylioglu Niyeti Qazi Julia Vandrey Yanni Schneider Jan Philipp Dobert Caleb Pitcairn Joseph Robert Mazzulli Friederike Zunke 
supported by the Deutsche Forschungsgemeinschaft(DFG),Bonn,Germany(SFB877,project B11,Grant no.:125440785);the Interdisciplinary Center for Clinical Research(IZKF)at the University Hospital of the University of Erlangen-Nuremberg(Jochen-Kalden funding programme N8);Research reported in this publication was partly supported by the National Institute of Neurological Disorders and Stroke of the National Institutes of Health under Award Number R01NS092823 and RF1NS109157.
Background Lysosomal dysfunction has been implicated in a number of neurodegenerative diseases such as Parkinson’s disease(PD).Various molecular,clinical and genetic studies have highlighted a central role of lysosom...
关键词：Dopaminergic neurons iPSC-derived models LYSOSOME Parkinson’s disease Protein trafficking SYNUCLEINOPATHY 
Propagation of tau and α-synuclein in the brain: therapeutic potential of the glymphatic system被引量：1
《Translational Neurodegeneration》2022年第1期667-689,共23页Douglas M.Lopes Sophie K.Llewellyn Ian F.Harrison 
research fellowship awards made to IFH from Alzheimer’s Research UK(ARUK-RF2019A-003)and Parkinson’s UK(F-1902).
Many neurodegenerative diseases, including Alzheimer’s disease and Parkinson’s disease, are characterised by the accumulation of misfolded protein deposits in the brain, leading to a progressive destabilisation of t...
关键词：Glymphatic PROPAGATION TAUOPATHY SYNUCLEINOPATHY CLEARANCE AQUAPORIN-4 
LRRK2 mutant knock-in mouse models: therapeutic relevance in Parkinson’s disease被引量：1
《Translational Neurodegeneration》2022年第1期790-808,共19页Eunice Eun Seo Chang Philip Wing-Lok Ho Hui-Fang Liu Shirley Yin-Yu Pang Chi-Ting Leung Yasine Malki Zoe Yuen-Kiu Choi David Boyer Ramsden Shu-Leong Ho 
Tai Hung Fai Charitable Foundation-Edwin S H Leong Research Programme for Parkinson’s Disease;The Henry G.Leong Endowed Professorship in Neurology;The Donation Fund for Neurology Research;Health and Medical Research Fund(HMRF),Food and Health Bureau,Hong Kong S.A.R.
Mutations in the leucine-rich repeat kinase 2 gene (LRRK2) are one of the most frequent genetic causes of both familial and sporadic Parkinson’s disease (PD). Mounting evidence has demonstrated pathological similarit...
关键词：Parkinson’s disease LRRK2 Knock-in mouse model NEUROTRANSMISSION Motor dysfunction Autophagy LYSOSOME Mitochondrial dysfunction SYNUCLEINOPATHY Hyperkinase activity LRRK2 inhibitor 
Glutathione peroxidase 4 deficit-mediated fer⁃roptosis contributes to dopaminergic neuron degeneration under synucleinopathy
《中国药理学与毒理学杂志》2021年第9期645-646,共2页SUN Jie LU Dan-hua LI Kun LIN Xiao-min PAN Ming-hai GONG Hai-biao SUN Wan-yang WANG Meng LIANG Lei Kurihara Hiroshi LI Yi-fang DUAN Wen-jun ZHANG Li HE Rong-rong 
National Key Research and Development Program of China(2017YFC1700404);Natural Science Foundation of China(81873209);Natural Science Foundation of China(U1801284);Natural Science Foundation of China(81903821);Natural Science Foundation of China(81973718);the Local Innovative and Research Teams Project of Guangdong Pearl River Talents Program(2017BT01Y036);GDUPS(2019),Fun⁃damental Research Funds for the Central Univer⁃sities(21620448);Natural Science Foundation of Guangdong Province(2019A 1515010909);Nat⁃ural Science Foundation of Guangdong Prov⁃ince(2021A1515011297);Science and Tech⁃nology Program of Guangzhou(201903010062);Science and Technology Program of Guang⁃zhou(907158833068),and the Innovation Team Project of Guangdong Provincial Department of Education(2020KCXT D003)。
OBJECTIVE Intracellular aggre⁃gation ofα-synuclein(SNCA)is one of the core pathological features of neurodegenerative disor⁃ders including Parkinson disease,whilst the detailed mechanism for consequently neuron loss ...
关键词：Parkinson disease ferroptosis glutathione peroxidase-4 phospholipid-omics Α-SYNUCLEIN 
Autophagy-lysosome pathway as a source of candidate biomarkers for Parkinson's disease
《Neuroimmunology and Neuroinflammation》2021年第2期101-110,共10页Nikolaos Papagiannakis Leonidas Stefanis 
Parkinson's disease(PD)is a neurodegenerative disorder characterized by progressive motor disturbances and affects more than 1%of the worldwide population.Diagnosis of PD relies on clinical history and physical examin...
关键词：MACROAUTOPHAGY chaperone-mediated autophagy SYNUCLEINOPATHY Lewy bodies Gaucher disease GLUCOCEREBROSIDASE Hsc70 
Vanishing cerebral vasculitis in a patient with Lewy pathology被引量：1
《The Journal of Biomedical Research》2017年第6期559-562,共4页Natalia Liapounova Kamran H.Azar J.Max Findlay Jian-Qiang Lu 
Immune-mediated mechanisms are involved in the pathogenesis of both cerebral vasculitis and Parkinson’s disease（PD, brainstem-predominant Lewy pathology）, but the presentation of cerebral vasculitis with comorbid L...
关键词：VASCULITIS cerebrovascular disease Parkinson’s disease Lewy pathology SYNUCLEINOPATHY immune pathogenesis 
共核蛋白病(synucleinopathy)的研究进展被引量：5
《国外医学（神经病学．神经外科学分册）》2001年第6期416-419,共4页黄越 王维治 
目前将α -共核蛋白 (α -synuclein)异常积聚所参与引起的神经系统变性病统称为共核蛋白病 (synucle inopathy) ,包括Alzheimer病 (AD)、肌萎缩侧索硬化 (ALS)、帕金森病 (PD)、多系统萎缩 (MSA)和路易体痴呆(DLB)等。研究α -共核蛋...
关键词：共核蛋白商α-共核蛋白 神经变性病 AD ALS PD MSA 
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