MACROAUTOPHAGY

作品数：19被引量：417H指数：7
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相关领域：生物学更多>>
相关机构：东北林业大学更多>>
相关期刊：《Cellular & Molecular Immunology》《Frontiers in Biology》《World Journal of Gastroenterology》《Genes & Diseases》更多>>
相关基金：国家自然科学基金重庆市自然科学基金上海市自然科学基金上海市青年科技启明星计划更多>>
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From macroautophagy to mitophagy:Unveiling the hidden role of mitophagy in gastrointestinal disorders
《World Journal of Gastroenterology》2024年第23期2934-2946,共13页Duo-Lun Gao Meng-Ran Lin Nan Ge Jin-Tao Guo Fan Yang Si-Yu Sun 
Supported by the National Natural Science Foundation of China,No.82100700;Fundamental Scientific Research Project from the Educational Department of Liaoning Province,No.LJKMZ20221191;High-quality Development Fund Project from the Science and Technology of Liaoning Province,No.2023JH2 and No.20200063;345 Talent Project of Shengjing Hospital,No.52-30B.
In this editorial,we comment on an article titled“Morphological and biochemical characteristics associated with autophagy in gastrointestinal diseases”,which was published in a recent issue of the World Journal of G...
关键词：MITOPHAGY Gastrointestinal diseases PARKIN Autophagic receptor Colorectal cancer Gastric cancer Inflammatory bowel disease 
Integrin β5 subunit regulates hyperglycemia-induced vascular endothelial cell apoptosis through FoxO1-mediated macroautophagy
《Chinese Medical Journal》2024年第5期565-576,共12页Xuze Lin Sizhuang Huang Side Gao Jinxing Liu Jiong Tang Mengyue Yu 
Background:Hyperglycemia frequently induces apoptosis in endothelial cells and ultimately contributes to microvascular dysfunction in patients with diabetes mellitus(DM).Previous research reported that the expression ...
关键词：Endothelial cell apoptosis INTEGRIN Autophagy Diabetes 
Mitochondrial dysfunction and mitophagy:crucial players in burn trauma and wound healing被引量：2
《Burns & Trauma》2023年第1期595-610,共16页Harshini Sheeja Prabhakaran Dongxue Hu Weifeng He Gaoxing Luo Yih-Cherng Liou 
supported by the Ministry of Education(MOE),Singapore,Tier 2(MOE-000395-01);Tier1(A-8000412-00-00)grants awarded to YCL.
Burn injuries are a significant cause of death worldwide,leading to systemic inflammation,multiple organ failure and sepsis.The progression of burn injury is explicitly correlated with mitochondrial homeostasis,which ...
关键词：MITOPHAGY MITOCHONDRIA Wound healing Burn trauma MACROAUTOPHAGY 
Beclin-1/LC3-II dependent macroautophagy was uninfluenced in ischemia-challenged vascular endothelial cells被引量：6
《Genes & Diseases》2022年第2期549-561,共13页Yaping Ma Chaofan Li Yan He Tiwei Fu Li Song Qingsong Ye Fugui Zhang 
This work was supported by the National Natural Science Foundation of China(No.81400493);Scientific and Technological Research Program of Chongqing Municipal Education Commission(No.KJQN20200429);Joint Medical Research Project by Chongqing Health Commission and Natural Science Foundation of Chongqing(No.2020GDRC008).
Autophagy has been extensively studied and occurs in many biological settings.However,a question remains as to whether ischemia enhances Beclin-1/LC3-II-dependent macroautophagy in vascular endothelial cells,as has be...
关键词：AUTOPHAGY Bioinformatics analysis Human umbilical vein endothelial cell Quantitative proteomics study Skin flap 
Autophagy-lysosome pathway as a source of candidate biomarkers for Parkinson's disease
《Neuroimmunology and Neuroinflammation》2021年第2期101-110,共10页Nikolaos Papagiannakis Leonidas Stefanis 
Parkinson's disease(PD)is a neurodegenerative disorder characterized by progressive motor disturbances and affects more than 1%of the worldwide population.Diagnosis of PD relies on clinical history and physical examin...
关键词：MACROAUTOPHAGY chaperone-mediated autophagy SYNUCLEINOPATHY Lewy bodies Gaucher disease GLUCOCEREBROSIDASE Hsc70 
Adaptive immunity at the crossroads of autophagy and metabolism被引量：3
《Cellular & Molecular Immunology》2021年第5期1096-1105,共10页Shree Padma Metur Daniel J.Klionsky 
The function of lymphocytes is dependent on their plasticity,particularly their adaptation to energy availability and environmental stress,and their protein synthesis machinery.Lymphocytes are constantly under metabol...
关键词：IMMUNOLOGY LYSOSOME MACROAUTOPHAGY STRESS 
Herbal cake-partitioned moxibustion inhibits colonic autophagy in Crohn’s disease via signaling involving distinct classes of phosphatidylinositol 3-kinases被引量：8
《World Journal of Gastroenterology》2020年第39期5997-6014,共18页Shi-Yuan Wang Ji-Meng Zhao Ci-Li Zhou Han-Dan Zheng Yan Huang Min Zhao Zhi-Ying Zhang Lu-Yi Wu Huan-Gan Wu Hui-Rong Liu 
the Program of Shanghai Academic Research Leader,No.17XD1403400;National Natural Sciences Foundation of China,No.81574079 and No.81873374;Three-year Action Plan Project of Shanghai Traditional Chinese Medicine Development,No.ZY(2018-2020)-CCCX-2004-01;Chinese Medicine Inheritance and Innovation"100 Million"Talent Project,Qi Huang Scholar;Shanghai Rising-Star Program,No.16QA1403400.
BACKGROUND Autophagy is an evolutionarily conserved biological process in eukaryotic cells that involves lysosomal-mediated degradation and recycling of related cellular components.Recent studies have shown that autop...
关键词：Crohn’s disease Colon MOXIBUSTION MACROAUTOPHAGY Immunity Phosphatidylinositol 3-kinase signaling 
Autophagy and inflammation in ischemic stroke被引量：110
《Neural Regeneration Research》2020年第8期1388-1396,共9页Yun Mo Yin-Yi Sun Kang-Yong Liu 
supported by the Natural Science Foundation of Shanghai of China,No.17ZR1425800(to KYL);the Shanghai Pudong District Health Bureau of China,No.PDZX2017-25(to KYL)
Appropriate autophagy has protective effects on ischemic nerve tissue,while excessive autophagy may cause cell death.The inflammatory response plays an important role in the survival of nerve cells and the recovery of...
关键词：AUTOPHAGY cerebral ischemia function INFLAMMASOME INFLAMMATION ischemia/refusion ischemic stroke MACROAUTOPHAGY NEUROINFLAMMATION oxygen glucose deprivation 
Dihydromyricetin and Salvianolic acid B inhibit alpha-synuclein aggregation and enhance chaperone-mediated autophagy被引量：13
《Translational Neurodegeneration》2019年第1期215-229,共15页Jia-Zhen Wu Mustafa Ardah Caroline Haikal Alexander Svanbergsson Meike Diepenbroek Nishant N.Vaikath Wen Li Zhan-You Wang Tiago F.Outeiro Omar M.El-Agnaf Jia-Yi Li 
We would like to acknowledge financial supports by the National Natural Science Foundation(81430025,81701265,31800898,U801681);Acknowledgements are also to the supports of the Swedish Research Council(K2015-61X-22297-03-4);EU-JPND(aSynProtec),EU-JPND(REfrAME),EU H2020-MSCA-ITN-2016(Syndegen),BAGADILICO-Excellence in Parkinson and Huntington Research,the Strong Research Environment MultiPark(Multidisciplinary research on Parkinson’s disease),the Swedish Parkinson Foundation(Parkinsonfonden),Torsten Söderbergs Foundation,Olle Engkvist Byggmästere Foundation;W.L.is supported by a scholarship from the China Scholarship Council;TFO is supported by the DFG Center for Nanoscaly Microscopy and Molecular Physiology of the Brain(CNMPB).
Background:Progressive accumulation ofα-synuclein is a key step in the pathological development of Parkinson’s disease.Impaired protein degradation and increased levels ofα-synuclein may trigger a pathological aggr...
关键词：chaperone-mediated autophagy MACROAUTOPHAGY ALPHA-SYNUCLEIN protein aggregation Parkinson disease lysosomal-associated membrane protein 
Increased Macroautophagy in Interferon-Gamma-Producing T Cells from Patients with Newly Diagnosed Systemic Lupus Erythematosus被引量：3
《Chinese Medical Journal》2018年第13期1527-1532,共6页Xiong-Yan Luo Jia-Li Yuan Jing Liu Cai-Nan Luo Ming-Hui Yang Qin Wei Min Yang Yong Chen Yi Liu Guo-Hua Yuan 
Background： Imbalance of interferon-gamma （IFN-γ）, interleukin （IL）-4, and IL-17 producing by T cells is confirmed to contribute to the pathogenesis of systemic lupus erythematosus （SLE）. Autophagy is now emer...
关键词：AUTOPHAGY Lupus Erythematosus SYSTEMIC T Helper cells 
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