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SYSTEMIC: 作品数：713被引量：1781H指数：18; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：杨再兴仲人前郑捷梁艳朱元倩更多>>; 相关机构：中山大学北京大学第二军医大学浙江大学医学院附属第二医院更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划中国博士后科学基金广东省自然科学基金更多>>

Gene therapy for spinal muscular atrophy:perspectives on the possibility of optimizing SMN1 delivery to correct all neurological and systemic perturbations: 《Neural Regeneration Research》2025年第7期2011-2012,共2页Sharon J.Brown Rafael J.Yáñez-Muñoz Heidi R.Fuller; supported by the Faculty Research Fund(Faculty of Medicine&Health Science,Keele University)Career Development Award–(April 2022)(to SJB)。; Spinal muscular atrophy(SMA)is a genetic condition that results in selective lower motor neuron loss with concomitant muscle weakness and atrophy.The genetic cause of SMA was understood in 1995 when loss or impairment...; 关键词：ATROPHY traditionally absolute

The synergistic antitumor effect of Karanahan technology and in situ vaccination using anti-OX40 antibodies: 《Oncology Research》2025年第5期1229-1248,共20页VERA RUZANOVA ANASTASIA PROSKURINA GENRIKH RITTER EVGENIYA DOLGOVA SOFYA OSHIKHMINA SVETLANA KIRIKOVICH EVGENIY LEVITES YAROSLAV EFREMOV OLEG TARANOV ALEXANDR OSTANIN ELENA CHERNYKH NIKOLAY KOLCHANOV SERGEY BOGACHEV; supported by Inga N.Zaitseva;“Karanahan”LLC and the Ministry of Science and Higher Education of the Russian Federation via the Institute of Cytology and Genetics(State Budget Project No.FWNR-2022-0016).; Objectives:Currently,there exist two approaches to the treatment of malignant neoplasms:the Karanahan technology and in situ vaccination,which are based on chronometric delivery of therapeutic agents to the tumor depe...; 关键词：Karanahan technology OX40 Antitumor immunity Tumor-initiating stem cells Systemic inflammatory reaction

Systemic immune indicators for predicting renal damage in newly diagnosed type 1 diabetic children: 《World Journal of Diabetes》2025年第5期148-158,共11页Lan-Fang Cao Qing-Bo Xu Li Yang; Supported by Jiangxi Provincial Health Commission Science and Technology Plan,No.SKJP220212334。; BACKGROUND Early kidney damage is a significant complication in children with newly diagnosed type 1 diabetes mellitus(T1DM).Systemic inflammation plays a key role in the development of diabetic nephropathy.Several in...; 关键词：Pediatric type 1 diabetes mellitus Systemic immune inflammation index Kidney injury Urinary albumin-tocreatinine ratio Inflammatory markers

Prognostic value of the preoperative systemic immune-inflammation nutritional index in patients with gastric cancer: 《World Journal of Clinical Oncology》2025年第4期130-141,共12页Li-Jing Wang Cai-Lu Lei Ting-An Wang Zhi-Feng Lin Shi-Jie Feng Tao Wei Yan-Qin Li Meng-Ru Shen Yan Li Liu-Feng Liao; Supported by the Scientific Research Project of Hospital Pharmacy of Guangxi Pharmaceutical Association in 2022,No.GXYXH1-202202.; BACKGROUND Gastric cancer(GC)is the fifth most common cancer and the third leading cause of cancer-related deaths in China.Many patients with GC frequently experience symptoms related to the disease,including anorexia...; 关键词：Systemic immune-inflammatory-nutritional index Prognostic nutritional index Nutritional risk index Gastric cancer Prognosis

A new framework for rural development assessment from a systemic perspective: A case from karst mountainous areas in southwest China: 《Journal of Mountain Science》2025年第4期1169-1188,共20页Zhang Yiyi LI Yangbing; supported by the National Natural Science Foundation of China(Grant No.42061035);the Guizhou Provincial Program on Commercialization of Scientific and Technological Achievements([2022]010)。; The mountainous rural regions of China are undergoing enormous changes in space and time.To a certain extent,this change has increased the difficulties in our understanding of rural development in mountainous areas an...; 关键词：Karst mountains Rural development rural regional system Rural revitalization

Systemic thrombosis with prothrombin Belgrade mutation in a Chinese patient:A case report: 《World Journal of Clinical Cases》2025年第10期35-39,共5页Yan-Feng Wu Yan Huang Bao-Hui Weng Shan Deng Li-Ya Pan Zhen Li; BACKGROUND Thrombophilia contributes to a significant increased risk of venous thromboembolism and can be either inherited or acquired.Hereditary thrombophilia may arise from various gene mutations,some of which have ...; 关键词：Arg596Gln Belgrade mutation THROMBOPHILIA PROTHROMBIN Case report

Systemic immune inflammation index as a predictor for atrial fibrillation recurrence after catheter ablation: 《World Journal of Cardiology》2025年第3期7-11,共5页Panayotis K Vlachakis Panagiotis Theofilis Athanasios Kordalis Dimitris Tousoulis; Atrial fibrillation(Afib)is a common arrhythmia with significant public health implications,affecting millions of individuals worldwide.Catheter ablation(CA)is an established treatment for drug-resistant Afib,yet recu...; 关键词：Atrial fibrillation Catheter ablation INFLAMMATION C-reactive protein Systemic immune inflammation index

Evaluating inflammatory status to predict atrial fibrillation recurrence following ablation:The role of systemic immuneinflammation index: 《World Journal of Cardiology》2025年第3期101-106,共6页Amedeo Tirandi Federico Carbone Luca Liberale Fabrizio Montecucco; Atrial fibrillation(AF)is the most common arrhythmia in humans,affecting more than 40 million people worldwide.Radiofrequency catheter ablation(RFCA)was first introduced as a treatment for AF by Haïssaguerre M in the ...; 关键词：Inflammation Atrial fibrillation Radiofrequency catheter ablation Systemic immune inflammation index APPLE score

Serologic parameters in young patients with retinal vein occlusion treated with anti-vascular endothelial growth factor: 《International Journal of Ophthalmology(English edition)》2025年第3期424-434,共11页Tong-Tong Niu Yun Xiao Wen-Juan Lyu Hao Zhou; Supported by Youth Cultivation Research Program of Beijing Road Medical Area,Xinjiang Military Region General Hospital,Xinjiang,China(No.2022jzbj105);Science and Technology Program of Urumqi Municipal Health and Wellness Commission(No.202360).; AIM:To assess the relationship between serological parameters and the prognosis of young patients with retinal vein occlusion(RVO)after intravitreal conbercept injection(IVC).METHODS:This study enrolled 100 young pati...; 关键词：retinal vein occlusion anti-vascular endothelial growth factor systemic immune-inflammatory index neutrophil-to-lymphocyte ratio

Risk factors of developing non-arteric ischemic optic neuropathy in patients with type 2 diabetes mellitus:a single-center retrospective cohort study: 《International Journal of Ophthalmology(English edition)》2025年第2期290-296,共7页Parinee Kemchoknatee Duanghathai Tangon Thansit Srisombut; AIM:To determine the risk factors and time to non-arteric ischemic optic neuropathy(NAION)occurrence among Thai type 2 diabetes mellitus(T2DM)patients.METHODS:A retrospective review of 266 newly diagnosed T2DM cases a...; 关键词：non-arteric ischemic optic neuropathy systemic vascular disease type 2 diabetes mellitus HYPERTENSION DYSLIPIDEMIA

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