From macroautophagy to mitophagy:Unveiling the hidden role of mitophagy in gastrointestinal disorders  

作　　者：Duo-Lun Gao Meng-Ran Lin Nan Ge Jin-Tao Guo Fan Yang Si-Yu Sun 

机构地区：[1]Department of Gastroenterology,Engineering Research Center of Ministry of Education for Minimally Invasive Gastrointestinal Endoscopic Techniques,Shengjing Hospital of China Medical University,Shenyang 110004,Liaoning Province,China

出　　处：《World Journal of Gastroenterology》2024年第23期2934-2946,共13页世界胃肠病学杂志（英文版）

基　　金：Supported by the National Natural Science Foundation of China,No.82100700;Fundamental Scientific Research Project from the Educational Department of Liaoning Province,No.LJKMZ20221191;High-quality Development Fund Project from the Science and Technology of Liaoning Province,No.2023JH2 and No.20200063;345 Talent Project of Shengjing Hospital,No.52-30B.

摘　　要：In this editorial,we comment on an article titled“Morphological and biochemical characteristics associated with autophagy in gastrointestinal diseases”,which was published in a recent issue of the World Journal of Gastroenterology.We focused on the statement that“autophagy is closely related to the digestion,secretion,and regeneration of gastrointestinal cells”.With advancing research,autophagy,and particularly the pivotal role of the macroautophagy in maintaining cellular equilibrium and stress response in the gastrointestinal system,has garnered extensive study.However,the significance of mitophagy,a unique selective autophagy pathway with ubiquitin-dependent and independent variants,should not be overlooked.In recent decades,mitophagy has been shown to be closely related to the occurrence and development of gastrointestinal diseases,especially inflammatory bowel disease,gastric cancer,and colorectal cancer.The interplay between mitophagy and mitochondrial quality control is crucial for elucidating disease mechanisms,as well as for the development of novel treatment strategies.Exploring the pathogenesis behind gastrointestinal diseases and providing individualized and efficient treatment for patients are subjects we have been exploring.This article reviews the potential mechanism of mitophagy in gastrointestinal diseases with the hope of providing new ideas for diagnosis and treatment.

关 键 词：MITOPHAGY Gastrointestinal diseases PARKIN Autophagic receptor Colorectal cancer Gastric cancer Inflammatory bowel disease 

分 类 号：R285[医药卫生—中药学]