Adaptive immunity at the crossroads of autophagy and metabolism  

作　　者：Shree Padma Metur Daniel J.Klionsky 

机构地区：[1]University of Michigan,Life Sciences Institute and Department of Molecular,Cellular and Developmental Biology,Ann Arbor,MI,USA

出　　处：《Cellular & Molecular Immunology》2021年第5期1096-1105,共10页中国免疫学杂志（英文版）

摘　　要：The function of lymphocytes is dependent on their plasticity,particularly their adaptation to energy availability and environmental stress,and their protein synthesis machinery.Lymphocytes are constantly under metabolic stress,and macroautophagy/autophagy is the primary metabolic pathway that helps cells overcome stressors.The intrinsic role of autophagy in regulating the metabolism of adaptive immune cells has recently gained increasing attention.In this review,we summarize and discuss the versatile roles of autophagy in regulating cellular metabolism and the implications of autophagy for immune cell function and fate,especially for T and B lymphocytes.

关 键 词：IMMUNOLOGY LYSOSOME MACROAUTOPHAGY STRESS 

分 类 号：R392[医药卫生—免疫学]