Mitochondrial dysfunction and mitophagy:crucial players in burn trauma and wound healing  

作　　者：Harshini Sheeja Prabhakaran Dongxue Hu Weifeng He Gaoxing Luo Yih-Cherng Liou 

机构地区：[1]Department of Biological Sciences,Faculty of Science,National University of Singapore,14 Science drive 4,117543 Singapore,Singapore [2]State Key Laboratory of Trauma,Burn and Combined Injury,Institute of Burn Research,Southwest Hospital,Third Military Medical University(Army Medical University),Gao Tan Yan Zheng Street,Sha Ping Ba District,Chongqing,400038,People’s Republic of China [3]Chongqing Key Laboratory for Disease Proteomics,Gao Tan Yan Zheng Street,Sha Ping Ba District,Chongqing,400038,People’s Republic of China

出　　处：《Burns & Trauma》2023年第1期595-610,共16页烧伤与创伤（英文）

基　　金：supported by the Ministry of Education(MOE),Singapore,Tier 2(MOE-000395-01);Tier1(A-8000412-00-00)grants awarded to YCL.

摘　　要：Burn injuries are a significant cause of death worldwide,leading to systemic inflammation,multiple organ failure and sepsis.The progression of burn injury is explicitly correlated with mitochondrial homeostasis,which is disrupted by the hyperinflammation induced by burn injury,leading to mitochondrial dysfunction and cell death.Mitophagy plays a crucial role in maintaining cellular homeostasis by selectively removing damaged mitochondria.A growing body of evidence from various disease models suggest that pharmacological interventions targeting mitophagy could be a promising therapeutic strategy.Recent studies have shown that mitophagy plays a crucial role in wound healing and burn injury.Furthermore,chemicals targeting mitophagy have also been shown to improve wound recovery,highlighting the potential for novel therapeutic strategies based on an in-depth exploration of the molecular mechanisms regulating mitophagy and its association with skin wound healing.

关 键 词：MITOPHAGY MITOCHONDRIA Wound healing Burn trauma MACROAUTOPHAGY 

分 类 号：R641[医药卫生—外科学]