Vanishing cerebral vasculitis in a patient with Lewy pathology  

作　　者：Natalia Liapounova Kamran H.Azar J.Max Findlay Jian-Qiang Lu 

机构地区：[1]Division of Pediatric Neurology,University of Alberta,Edmonton,Alberta,Canada [2]Department of Pathology,The North East Health Services Delivery Area,Fort St.John,British Columbia,Canada [3]Division of Neurosurgery,University of Alberta,Edmonton,Alberta,Canada [4]Neuropathology Section,Department of Laboratory Medicine and Pathology,University of Alberta,University of Alberta,Edmonton,Alberta,Canada

出　　处：《The Journal of Biomedical Research》2017年第6期559-562,共4页生物医学研究杂志（英文版）

摘　　要：Immune-mediated mechanisms are involved in the pathogenesis of both cerebral vasculitis and Parkinson’s disease（PD, brainstem-predominant Lewy pathology）, but the presentation of cerebral vasculitis with comorbid Lewy pathology has not yet been reported. Here we present a case of pathologically confirmed vasculitis in a 73-year-old male patient whose postmortem examination revealed Lewy pathology diagnostic of PD. This case study suggests a comorbidity of cerebral vasculitis and Lewy pathology, as well as potential pathogenic interactions between these two disorders with immune-mediated mechanisms.Immune-mediated mechanisms are involved in the pathogenesis of both cerebral vasculitis and Parkinson’s disease（PD, brainstem-predominant Lewy pathology）, but the presentation of cerebral vasculitis with comorbid Lewy pathology has not yet been reported. Here we present a case of pathologically confirmed vasculitis in a 73-year-old male patient whose postmortem examination revealed Lewy pathology diagnostic of PD. This case study suggests a comorbidity of cerebral vasculitis and Lewy pathology, as well as potential pathogenic interactions between these two disorders with immune-mediated mechanisms.

关 键 词：VASCULITIS cerebrovascular disease Parkinson’s disease Lewy pathology SYNUCLEINOPATHY immune pathogenesis 

分 类 号：R742.5[医药卫生—神经病学与精神病学]