CLEARANCE

作品数：334被引量：1108H指数：16
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Targeting the glymphatic system to promoteα-synuclein clearance:a novel therapeutic strategy for Parkinson's disease
《Neural Regeneration Research》2026年第1期233-247,共15页Xiaoyue Lian Zhenghao Liu Zuobin Gan Qingshan Yan Luyao Tong Linan Qiu Yuntao Liu Jiang-fan Chen Zhihui Li 
supported by the National Natural Science Foundation of China,No.81971031(to ZL);the National Key Research and Development Program of China,No.2022YFE0210100(to JFC);the National Natural Science Foundation of China(Original Exploration Project),No.82151308(to JFC);the National Natural Science Foundation of China(Research Fund for International Senior Scientists),No.82150710558(to JFC);Science&Technology Initiative STI2030-Major Projects,No.2021ZD0203400(to JFC);Key Research and Development Program of Zhejiang Province,No.2023C03079(to JFC);Scientific Research Starting Foundation of Oujiang Laboratory(Zhejiang Laboratory for Regenerative Medicine,Vision and Brain Health),No.OJQDSP2022007(to JFC);Project of State Key Laboratory of Ophthalmology,Optometry and Visual Science,Wenzhou Medical University,No.J01-20190101(to JFC);Scientific Research Starting Foundation of Wenzhou Medical University,No.QTJ12003(to JFC);Department of Science and Technology of Zhejiang Province,No.2023ZY1011(to JFC)。
The excessive buildup of neurotoxicα-synuclein plays a pivotal role in the pathogenesis of Parkinson's disease,highlighting the urgent need for innovative therapeutic strategies to promoteα-synuclein clearance,parti...
关键词：AQUAPORIN-4 ASTROCYTES cerebrospinal fluid glymphatic system interstitial fluid neurotoxic protein clearance Parkinson's disease perivascular spaces sleep disturbance Α-SYNUCLEIN 
Systematic review of amyloid-beta clearance proteins from the brain to the periphery:implications for Alzheimer's disease diagnosis and therapeutic targets
《Neural Regeneration Research》2025年第12期3574-3590,共17页Letian Huang Mingyue Liu Ze Li Bing Li Jiahe Wang Ke Zhang 
supported by the National Natural Science Foundation of China,No.81571046(to KZ);Key Project of Educational Department of Liaoning Province,No.LJKZ0755(to KZ);Project of Department of Science&Technology of Liaoning Province,No.2023JH2/20200116(to KZ);Shenyang Young and Middleaged Innovative Talents Support Program,No.RC210240(to KZ);the 345 Talent Project of Shengjing Hospital of China Medical University(to LH)。
Amyloid-beta clearance plays a key role in the pathogenesis of Alzheimer's disease.H oweve r,the variation in functional proteins involved in amyloid-beta clearance and their correlation with amyloid-beta levels remai...
关键词：Alzheimer’s disease amyloid-β blood‒brain barrier cerebrospinal fluid diagnostic biomarker meta-analysis mild cognitive impairment peripheral blood systematic review therapeutic targets 
Effect and Safety of Fuzheng Huazhuo Decoction against Prolonged SARS-CoV-2 Clearance:A Retrospective Cohort Study
《Chinese Journal of Integrative Medicine》2025年第5期387-393,共7页ZHANG Wen WU Hong-ze XU Xiang-ru PU Yu-ting CHEN Cai-yu DENG Rou CAO Min SUN Ding YI Hui ZHOU Shuang FANG Bang-jiang 
Supported by the State Administration of Traditional Chinese Medicine;Traditional Chinese Medicine for the Prevention and Treatment of Novel Coronavirus Pneumonia Emergency and Special Project (No. 2022ZYLCYJ05-4);Shanghai University of Traditional Chinese Medicine,Traditional Chinese Medicine on Prevention and Treatment of Novel Coronavirus Pneumonia Emergency and Special Project (Nos. 2022YJ-03 and 2022YJ-06)。
Objective To evaluate the effect and safety of Chinese medicine(CM)Fuzheng Huazhuo Decoction(FHD)in treating patients with coronavirus disease 2019(COVID-19)who persistently tested positive for severe acute respirator...
关键词：Chinese medicine Fuzheng Huazhuo Decoction coronavirus disease 2019 prolonged viral clearance 
Design Strategies for Reconstruction and Expansion of Insufficient Clearance Sections in Highway Interchanges
《Journal of World Architecture》2025年第2期1-7,共7页Shuai Li Zhipan Yang Jianchao Xu China 
Combining practical engineering projects, this article analyzes the design strategies for the reconstruction and expansion of insufficient clearance sections in highway interchanges. This includes an overview of the p...
关键词：HIGHWAY INTERCHANGE Insufficient clearance Reconstruction and expansion design Design scheme 
Pathways Related to ROS Production, Clearance, and Signal Transduction during Cold Response in Brassica napus L.with Strong Cold Resistance
《Phyton-International Journal of Experimental Botany》2025年第3期739-762,共24页Weiliang Qi Wancang Sun Li Ma Xiaolong Li Haiqing Liu Cairong Yang Ziyao Wei 
supported by the National Nature Science Foundation Regional Fund Project(32360455);QingyangCity Joint Research Fund Project—Major Project(QY-STK-2024A-046);Doctoral Foundation of Longdong University(XYBYZK2107);University Teachers Innovation Fund Project of Gansu Province(2025A-198).
Brassica napus L. (B. napus), recognized as a significant cash and oil crop, faces challenges in popularization and application in northern China due to its limited cold resistance. Clarifying the mechanism of cold st...
关键词：Brassica napus L. cold stress comparative transcriptome ROS 
Blade Cutting Influence on Centrifugal Pump Noise Reduction
《Fluid Dynamics & Materials Processing》2025年第3期623-644,共22页Tianpeng Li Yujun Duan Qianghu Ji 
A centrifugal pump with a specific speed ns=67 is considered in this study to investigate the impact of blade cutting(at the outlet edge)on the fluid-induced noise,while keeping all the other geometric parameters unch...
关键词：Centrifugal pump IMPELLER cutting distance CLEARANCE sound field 
Copper-Bearing Metal-Organic Framework with Mucus-Penetrating Function for the Multi-Effective Clearance of Mucosal Colonized Helicobacter pylori
《Research》2025年第1期164-180,共17页Chunxi Shu Wei Zhang Yiwei Zhang Yu Li Xinbo Xu Yanan Zhou Yue Zhang Qin Zhong Cong He Yin Zhu Xiaolei Wang 
funded by the National Natural Science Foundation of China(grant no.82170580 to Y.Z.);the Key Research and Development Program of Jiangxi Province(20212BBG73004 to X.W.);the Postdoctoral Fellowship Program of CPSF(GZB20230283 to W.Z.).
Helicobacter pylori colonizes over 50%of people worldwide.Biofilm formation through penetrating gastric mucus and resistance acquired by H.pylori markedly reduces the efficacy of traditional antibiotics.The present tr...
关键词：triple therapy mucus penetrating function penetrating gastric mucus mucosal colonized Helicobacter pylori copper bearing metal organic framework helicobacter pylori multi effective clearance traditional antibioticsthe 
Liver as a new target organ in Alzheimer's disease:insight from cholesterol metabolism and its role in amyloid-beta clearance
《Neural Regeneration Research》2025年第3期695-714,共20页Beibei Wu Yuqing Liu Hongli Li Lemei Zhu Lingfeng Zeng Zhen Zhang Weijun Peng 
financially supported by the Science and Technology Innovation Program of Hunan Province,No.2022RC1220(to WP);China Postdoctoral Science Foundation,No.2022M711733(to ZZ);the National Natural Science Foundation of China,No.82160920(to ZZ);Hebei Postdoctoral Scientific Research Project,No.B2022003040(to ZZ);Hunan Flagship Department of Integrated Traditional Chinese and Western Medicine(to WP)。
Alzheimer's disease,the primary cause of dementia,is characterized by neuropathologies,such as amyloid plaques,synaptic and neuronal degeneration,and neurofibrillary tangles.Although amyloid plaques are the primary ch...
关键词：ABCA1 Alzheimer's disease AMYLOID-BETA apolipoprotein E cholesterol metabolism LIVER liver X receptor low-density lipoprotein receptor-related protein 1 peripheral clearance tauroursodeoxycholic acid 
Neuronal activities drive brain waste clearance through the glymphatic system
《Acta Pharmaceutica Sinica B》2025年第2期1193-1195,共3页Lin-jian Wang Xiwen Ma Jianping Ye 
supported by the National Natural Science Foundation of China(Grant No.32271220).
Neurons are the main organizers of neurological activities in the brain.However,its role remains largely unknown in regulating waste clearance in the brain.This issue is addressed in a recent study published in Nature...
关键词：Alzheimer disease NEURON Glymphatic system Cerebrospinal fluid perfusion Brain clearance 
Enhanced radiotheranostic targeting of integrinα5β1 with PEGylation-enabled peptide multidisplay platform(PEGibody):A strategy for prolonged tumor retention with fast blood clearance
《Acta Pharmaceutica Sinica B》2025年第2期692-706,共15页Siqi Zhang Xiaohui Ma Jiang Wu Jieting Shen Yuntao Shi Xingkai Wang Lin Xie Xiaona Sun Yuxuan Wu Hao Tian Xin Gao Xueyao Chen Hongyi Huang Lu Chen Xuekai Song Qichen Hu Hailong Zhang Feng Wang Zhao-Hui Jin Ming-Rong Zhang Rui Wang Kuan Hu 
supported by the National Natural Science Foundation of China(No.82372002);the Nonprofit Central Research Institute Fund of the Chinese Academy of Medical Sciences(No.2022-RC350-04,China);the CAMS Innovation Fund for Medical Sciences(Nos.2021-I2M-1-026(2023),2022-I2M-2-002-2,and 2021-I2M-3-001(2023),China);the National Key Research and Development Program of China(No.2022YFE0111700);the Beijing Nova Program to Kuan Hu(No.0104002,China);supported by the Beijing Natural Science Foundation(No.L234044,China);the Fundamental Research Funds for the Central Universities(Nos.3332023044 and 3332023151,China);the CIRP Open Fund of Radiation Protection Laboratories(No.ZHYLYB2021005,China);the China National Nuclear Corporation Young Talent Program.
Peptide-based radiopharmaceuticals targeting integrinα5β1 show promise for precise tumor diagnosis and treatment.However,current peptide-based radioligands that targetα5β1 demonstrate inadequate in vivo performanc...
关键词：Integrinα5β1 PEPTIDE PET imaging Targeted radionuclide therapy PEGYLATION TUMOR Multidisplay PEGibody 
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