AMYLOID-BETA

作品数：82被引量：283H指数：9
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相关领域：医药卫生生物学更多>>
相关作者：崔进曹立宁钟勇裴刚王丽威更多>>
相关机构：河南省农业科学院动物免疫学重点实验室同济大学北京大学厦门大学更多>>
相关期刊：《Bioactive Materials》《China Medical Abstracts(Internal Medicine)》《Current Medical Science》《Neuroscience Bulletin》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划中国博士后科学基金北京市自然科学基金更多>>
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Systematic review of amyloid-beta clearance proteins from the brain to the periphery:implications for Alzheimer's disease diagnosis and therapeutic targets
《Neural Regeneration Research》2025年第12期3574-3590,共17页Letian Huang Mingyue Liu Ze Li Bing Li Jiahe Wang Ke Zhang 
supported by the National Natural Science Foundation of China,No.81571046(to KZ);Key Project of Educational Department of Liaoning Province,No.LJKZ0755(to KZ);Project of Department of Science&Technology of Liaoning Province,No.2023JH2/20200116(to KZ);Shenyang Young and Middleaged Innovative Talents Support Program,No.RC210240(to KZ);the 345 Talent Project of Shengjing Hospital of China Medical University(to LH)。
Amyloid-beta clearance plays a key role in the pathogenesis of Alzheimer's disease.H oweve r,the variation in functional proteins involved in amyloid-beta clearance and their correlation with amyloid-beta levels remai...
关键词：Alzheimer’s disease amyloid-β blood‒brain barrier cerebrospinal fluid diagnostic biomarker meta-analysis mild cognitive impairment peripheral blood systematic review therapeutic targets 
Misfolded amyloid-beta conformational variants(strains)as drivers of Alzheimer's disease neuropathology
《Neural Regeneration Research》2025年第11期3219-3220,共2页Salvatore Saieva Rodrigo Morales 
supported by a grant from NIH(R01AI132695)to RM。
Pathological and clinical variability in Alzheimer's disease(AD):AD is clinically cha racterized by progressive memory loss and cognitive impairment.From a pathological point of view,the main features of AD are the de...
关键词：AMYLOID ALZHEIMER clinical 
Treadmill exercise in combination with acousto-optic and olfactory stimulation improves cognitive function in APP/PS1 mice through the brain-derived neurotrophic factor-and Cygb-associated signaling pathways被引量：1
《Neural Regeneration Research》2025年第9期2706-2726,共21页Biao Xiao Chaoyang Chu Zhicheng Lin Tianyuan Fang Yuyu Zhou Chuxia Zhang Jianghui Shan Shiyu Chen Liping Li 
supported by the National Natural Science Foundation of China,No.82001155(to LL);the Natural Science Foundation of Zhejiang Province,No.LY23H090004(to LL);the Natural Science Foundation of Ningbo,No.2023J068(to LL);the Fundamental Research Funds for the Provincial Universities of Zhejiang Province,No.SJLY2023008(to LL);the College Students'Scientific and Technological Innovation Project(Xin Miao Talent Plan)of Zhejiang Province,No.2022R405A045(to CC);the Student Research;Innovation Program(SRIP)of Ningbo University,Nos.20235RIP1919(to CZ),2023SRIP1938(to YZ);the K.C.Wong Magna Fund in Ningbo University。
A reduction in adult neurogenesis is associated with behavioral abnormalities in patients with Alzheimer's disease.Consequently,enhancing adult neurogenesis represents a promising therapeutic approach for mitigating d...
关键词：acousto-optic stimulation adult neurogenesis Alzheimer's disease amyloid precursor protein/presenilin 1 mice amyloid-beta deposition brain cell apoptosis cognitive impairment depression-like behavior involuntary treadmill exercise olfactory stimulation serum metabolites 
FUBP3 mediates the amyloid-β-induced neuronal NLRP3 expression
《Neural Regeneration Research》2025年第7期2068-2083,共16页Jing Yao Yuan Li Xi Liu Wenping Liang Yu Li Liyong Wu Zhe Wang Weihong Song 
supported by a grant from Key Laboratory of Alzheimer's Disease of Zhejiang Province,Institute of Aging,Wenzhou Medical University,No.ZJAD-2021002(to ZW)。
Alzheimer's disease is characterized by deposition of amyloid-β,which forms extracellular neuritic plaques,and accumulation of hyperphosphorylated tau,which aggregates to form intraneuronal neurofibrillary tangles,in...
关键词：5′end trimming Alzheimer's disease AMYLOID-BETA amyloid-β-dependent transcription FUBP3 INFLAMMASOME inflammation neuron NLRP3 tau transcription factor 
Amyloid-beta pathology-induced nanoscale synaptic disruption:the case of the GABA_B-GIRK assembly
《Neural Regeneration Research》2025年第5期1409-1410,共2页Rafael Lujan Alejandro Martín-Belmonte Sergi Ferré Francisco Ciruela 
Alzheimer's disease (AD) is characterized by an imbalance between excitatory and inhibitory brain networks,leading to aberrant homeostatic synaptic plasticity.AD has progressively been recognized as syna ptopathy and ...
关键词：ALZHEIMER PATHOLOGY 
Corrigendum: Activation of autophagy by Citri Reticulatae Semen extract ameliorates amyloid-beta-induced cell death and cognition deficits in Alzheimer’s disease
《Neural Regeneration Research》2025年第4期1041-1041,共1页
In the article titled“Activation of autophagy by Citri Reticulatae Semen extract ameliorates amyloid-beta-induced cell death and cognition deficits in Alzheimer’s disease”published on pages 2467-2479,Issue 11,Volum...
关键词：SEMEN ALZHEIMER AMYLOID 
Liver as a new target organ in Alzheimer's disease:insight from cholesterol metabolism and its role in amyloid-beta clearance
《Neural Regeneration Research》2025年第3期695-714,共20页Beibei Wu Yuqing Liu Hongli Li Lemei Zhu Lingfeng Zeng Zhen Zhang Weijun Peng 
financially supported by the Science and Technology Innovation Program of Hunan Province,No.2022RC1220(to WP);China Postdoctoral Science Foundation,No.2022M711733(to ZZ);the National Natural Science Foundation of China,No.82160920(to ZZ);Hebei Postdoctoral Scientific Research Project,No.B2022003040(to ZZ);Hunan Flagship Department of Integrated Traditional Chinese and Western Medicine(to WP)。
Alzheimer's disease,the primary cause of dementia,is characterized by neuropathologies,such as amyloid plaques,synaptic and neuronal degeneration,and neurofibrillary tangles.Although amyloid plaques are the primary ch...
关键词：ABCA1 Alzheimer's disease AMYLOID-BETA apolipoprotein E cholesterol metabolism LIVER liver X receptor low-density lipoprotein receptor-related protein 1 peripheral clearance tauroursodeoxycholic acid 
A systematic review of salivary biomarkers in Parkinson's disease被引量：2
《Neural Regeneration Research》2024年第12期2613-2625,共13页Maria Ilenia De Bartolo Daniele Belvisi Romina Mancinelli Matteo Costanzo Claudia Caturano Giorgio Leodori Alfredo Berardelli Giovanni Fabbrini Giorgio Vivacqua 
The search fo r reliable and easily accessible biomarkers in Parkinson's disease is receiving a growing emphasis,to detect neurodegeneration from the prodromal phase and to enforce disease-modifying therapies.Despite ...
关键词：ALPHA-SYNUCLEIN AMYLOID-BETA autophagy DJ-1 NEURODEGENERATION NEUROINFLAMMATION Parkinson's disease salivary biomarkers tau 
Activation of autophagy by Citri Reticulatae Semen extract ameliorates amyloid-beta-induced cell death and cognition deficits in Alzheimer’s disease被引量：4
《Neural Regeneration Research》2024年第11期2467-2479,共13页Yong Tang Jing Wei Xiao-Fang Wang Tao Long Xiaohong Xiang Liqun Qu Xingxia Wang Chonglin Yu Xingli Xiao Xueyuan Hu Jing Zeng Qin Xu Anguo Wu Jianming Wu Dalian Qin Xiaogang Zhou Betty Yuen-Kwan Law 
supported by FDCT grants from the Macao Science and Technology Development Fund,China,No.002/2023/ALC(to BYKL);Foshan Medicine Dengfeng Project of China 2019-2021(to BYKL);the Science and Technology Program of Sichuan Province,Nos.2022YFS0620(to DQ)and MZGC20230041(to XFW);the TCMs Commission of Sichuan Province,No.2021MS469(to YT);the Science and Technology Program of Luzhou,No.2022-WGR-194(to YT);the Southwest Medical University Science and Technology Program,No.2021NJXNYD04(to DQ).
Amyloid-beta-induced neuronal cell death contributes to cognitive decline in Alzheimer’s disease.Citri Reticulatae Semen has diverse beneficial effects on neurodegenerative diseases,including Parkinson’s and Hunting...
关键词：Alzheimer’s disease AMYLOID-BETA apoptosis AUTOPHAGY Caenorhabditis elegans Citri Reticulatae Semen 
Suppression of mature TAU isoforms prevents Alzheimer's disease-like amyloid-beta oligomer-induced spine loss in rodent neurons被引量：1
《Neural Regeneration Research》2024年第8期1655-1657,共3页Sarah Buchholz Hans Zempel 
supported by the Deutsche Forschungsgemeinschaft and the Else-Kroner-Fresenius-Stiftung(to HZ)。
Introduction:TAU isoforms as disease mediators:The microtubule-associated protein TAU is predominantly present in the axons of neurons under physiological conditions.In Alzheimer’s disease(AD)and related tauopathies,...
关键词：Alzheimer Zimmer TAU 
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