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Recent advances in immunotherapy targeting amyloid-beta and tauopathies in Alzheimer’s disease: 《Neural Regeneration Research》2026年第2期577-587,共11页Sha Sha Lina Ren Xiaona Xing Wanshu Guo Yan Wang Ying Li Yunpeng Cao Le Qu; supported by the Nature Science Foundation of Liaoning Province,Nos.2022-MS-211,2021-MS-064,and 2024-MS-048(all to YC).; Alzheimer’s disease,a devastating neurodegenerative disorder,is characterized by progressive cognitive decline,primarily due to amyloid-beta protein deposition and tau protein phosphorylation.Effectively reducing the...; 关键词：Alzheimer’s disease amyloid deposits AMYLOID-BETA antibody cognitive dysfunction dementia IMMUNOTHERAPY OLIGOMER preventive immunization tau hyperphosphorylation

Control of H_(2)S synthesis by the monomer-oligomer transition of OsCBSX3 for modulating rice growth-immunity balance: 《Molecular Plant》2025年第2期350-365,共16页Haimiao Zhang Baolong Sun Muhammad Zunair Latif Yang Liu Lei Lv Tao Wu Yang Li Ziyi Yin Chongchong Lu Haipeng Zhao Lingguang Kong Xinhua Ding; supported by the National Natural Science Foundation of China(32272557 and 32072500);the Major Basic Research Project of the Natural Science Foundation of Shandong Province(ZR2022ZD23 and ZR2024ZD07);the Shandong Province Key Research and Development Plan(2024CXGC010908 and 2024LZGCQY009);the Taishan Scholar Program of Shandong Province(tstp20221117);the“First Class Discipline"Construction Project of Shandong Agricultural University(811)。; Hydrogen sulfide(H_(2)S)is recognized as an important gaseous signaling molecule,similar to nitric oxide and carbon monoxide.However,less is known about the biosynthetic mechanism of H_(2)S in plants and its role in p...; 关键词：hydrogen sulfide bacterial leaf streak bacterial blight Xanthomonas oryzae OLIGOMERIZATION

Revisit the Gibbs-Thomson Equation Fitting of Poly(butylene succinate)Based on Oligomer Extended-Chain Crystals: 《Chinese Journal of Polymer Science》2025年第2期392-398,共7页Na Li Yu-Pei Tian Tian-Yu Wu Qiong Zhou Hai-Mu Ye; financially supported by the National Natural Science Foundation of China(Nos.22473113 and 22173116).; The equilibrium melting point(T_(m)^(0))is a crucial thermodynamic parameter for characterizing the crystallization and melting behavior of semi-crystalline polymers.However,the direct measurement of T_(m)^(0) poses a...; 关键词：Equilibrium melting point Extended-chain crystal Gibbs-Thomson equation Inclusion complex

Suppression of mature TAU isoforms prevents Alzheimer's disease-like amyloid-beta oligomer-induced spine loss in rodent neurons被引量：1: 《Neural Regeneration Research》2024年第8期1655-1657,共3页Sarah Buchholz Hans Zempel; supported by the Deutsche Forschungsgemeinschaft and the Else-Kroner-Fresenius-Stiftung(to HZ)。; Introduction:TAU isoforms as disease mediators:The microtubule-associated protein TAU is predominantly present in the axons of neurons under physiological conditions.In Alzheimer’s disease(AD)and related tauopathies,...; 关键词：Alzheimer Zimmer TAU

Synthesis of Long-Chain Oligomeric Donor and Acceptors via Direct Arylation for Organic Solar Cells: 《Chinese Journal of Chemistry》2024年第5期523-532,共10页Yu Wu Xin-Yu He Xu-Min Huang Ling-Jun Yang Peng Liu Na Chen Chang-Zhi Li Shi-Yong Liu; The National Natural Science Foundation of China(No.22169009);Jiangxi Provincial Natural Science Foundation(No.20212ACB204007);Jiangxi Provincial Key Laboratory of Functional Molecular Materials Chemistry(20212BCD42018)are appreciated for financial support。; The rapid synthesis of structurally complicated electron donors&acceptors still remains a major challenge in organic solar cells(OSC).In this work,we developed a highly efficient strategy to access long-chain oligomer...; 关键词：Long-chainπ-conjugated oligomer Organic solar cells Direct arylation Atom-economical synthesis CYCLOPENTADITHIOPHENE BENZOTHIADIAZOLE C—H activation CONJUGATION Oligomers

Human islet amyloid polypeptide oligomers stabilized and probed by MAS NMR: 《Magnetic Resonance Letters》2024年第1期61-62,共2页Ziwei Chang Zhengfeng Zhang; The capture and characterization of oligomers are extremely important in the studies of amyloid aggregation of proteins and peptides.Oligomers are critical intermediates that can impact the structures of amyloid fibri...; 关键词：AGGREGATION OLIGOMER STABILIZED

De novo design of highly efficient type-Ⅰphotosensitizer based onπ-conjugated oligomer for photodynamic eradication of multidrug-resistant bacterial infections: 《Chinese Chemical Letters》2024年第3期389-393,共5页Qi Zhao Guangchao Qing Jie Yu Ying Liu Jianliang Shen Yang Luo Xingjie Zan Shengliang Li; financially supported by the National Natural Science Foundation of China(Nos.82125022,82072383,31800833,21977081,52173135 and 22207024);Zhejiang Provincial Natural Science of Foundation of China(No.LZ19H180001);Wenzhou Medical University(No.KYYW201901);University of Chinese Academy of Science(Nos.WIBEZD2017001-03 and WIUCASYJ2020001)。; Traditional photosensitizers show limited singlet oxygen generation in hypoxic infection lesions,which greatly suppress their performance in antibacterial therapy.Meanwhile,there still is lack of feasible design strat...; 关键词：Photodynamic therapy Antibacterial Type-Ⅰphotosensitizers Multidrug-resistant bacteria Conjugated oligomers

Design and synthesis of thiol-terminated imidothioether oligomer as thermally latent hardener and modifier for high-performance epoxy/thiol thermosets: 《Science China Chemistry》2024年第2期632-641,共10页Xing Liu Jianjun Zhou Shumei Liu Jianqing Zhao; supported by the project for Enterprise Innovation Plan-High level Enterprise Research Institute’s Program of Guangzhou (202205110010)。; Conventional base-catalyzed epoxy/aliphatic thiol systems have a poor storage stability,and are impossible to be one-pot systems.A widely accepted solution is to use the latent catalysts,which are usually insoluble an...; 关键词：thiol-terminated imidothioether oligomer epoxy systems thiol exchange reaction thermal latency high performance

Plasma amyloid-beta oligomer and phosphorylated tau:diagnostic tools for progressive Alzheimer's disease被引量：3: 《Neural Regeneration Research》2023年第11期2391-2392,共2页Seong Soo A.An John P.Hulme; National Research Foundation of Korea (NRF) by the Korean Government (2020R1A2B5B01002463&2021R1A6A1A03038996)(to JPH)。; Introduction:Spanning the three stages of the Alzheimer’s disease (AD) continuum,amyloid-beta(Aβ40and Aβ42) oligomers (AβO’s) and tau protein constitute a set of biomarkers ideally suited for the non-invasive mon...; 关键词：AMYLOID TAU ALZHEIMER

Flame-retardant oligomeric electrolyte additive for self-extinguishing and highly-stable lithium-ion batteries:Beyond small molecules: 《Journal of Energy Chemistry》2023年第9期374-384,共11页Yi-Zhou Quan Qing-Song Liu Mei-Chen Liu Guo-Rui Zhu Gang Wu Xiu-Li Wang Yu-Zhong Wang; supported by the National Natural Science Foundation of China (51773134, U19A2095);the Sichuan Science and Technology Program (2019YFH0112);the Fundamental Research Funds for the Central Universities;Institutional Research Fund from Sichuan University (2021SCUNL201);the 111 Project (B20001)。; Preparing both safe and high-performance lithium-ion batteries(LIBs) based on commonly used commercial electrolytes is highly desirable,yet challenging.To overcome the poor compatibility of conventional small-molecula...; 关键词：Flame-retardant oligomer Safety Compatibility Graphite anodes Lithium-ion batteries

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