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EGFR-mediated crosstalk between vascularendothelial cells and hepatocytes promotesPiezo1-dependent liver regeneration
《Genes & Diseases》2025年第3期411-427,共17页Yuelei Hu Guifang Du Chao Li Rui Wang Juan Liu Yunfang Wang Jiahong Dong 
supported by the National Key Research and Development Program of China(No.2022YFA1103400);the CAMS Innovation Fund for Medical Sciences(No.2019-I2M-5e056);the National Natural Science Foundation of China(No.81930119,92168207,32371477,82090051);the Precision Medicine Research Program of Tsinghua University(No.10001020612);the National High Level Hospital Clinical Research Funding(China)(No.2022-NHLHCRF-LX-03-0102).
Hepatocyte proliferation is essential for recovering liver function after injury. Inliver surgery, the mechanical stimulation induced by hemodynamic changes triggers vascularendothelial cells (VECs) to secrete large a...
关键词：EGFR Hemodynamic changes Liver regeneration Piezo1 Vascular endothelial cells 
Apolipoprotein A-I binding protein-mediated neuroprotection in glaucomatous neuroinflammation and neurodegeneration
《Neural Regeneration Research》2025年第5期1414-1415,共2页Sinwoo Hwang Seunghwan Choi Soo-Ho Choi Keun-Young Kim Yury I.Miller Won-Kyu Ju 
supported by the National Institutes of Health grants EY034116 (to WKJ, KYK, and SHC) and AG081037 (to YIM and WKJ)。
Glaucoma is a multifactorial eye disorder that can cause vision loss and irreversible blindness,affecting individ uals aged 40 to 80 yea rs worldwide.Due to the aging population,it is expected that the number of peopl...
关键词：IRREVERSIBLE PASS primarily 
Bacterial-mediated recovery of copper from low-grade copper sulfide using fly ash and bacterial community dynamics
《International Journal of Minerals,Metallurgy and Materials》2025年第5期1044-1055,共12页Wei Chen Ming Zhang Shenghua Yin Yun Zhou 
supported by China National Postdoctoral Program for Innovative Talents(No.BX20230041);China Postdoctoral Science Foundation(No.2024M750186);the Key Program of National Natural Science Foundation of China(No.52034001);Open Foundation of State Envir-onmental Protection Key Laboratory of Mineral Metallurgic-al Resources Utilization and Pollution Control(No.HB202303).
Bioleaching is confronted with problems,such as low efficiency,long production cycle length,and vegetation destruction.In order to solve problems above,fly ash and low-grade copper sulfide ores were used to investigat...
关键词：low-grade copper sulfides fly ash bioleaching behavior bacterial community succession 
Shenfushu granules attenuate diabetic kidney disease by inhibiting PIK3R1/protein kinase B/heparanase-mediated endothelialmesenchymal transition
《World Journal of Diabetes》2025年第5期297-316,共20页Xi-Ding Yang Si-Jia Ma Da-Xiong Xiang Yong-Yu Yang 
Supported by the Changsha Science and Technology Major Project,No.kh2205035;the Hunan Traditional Chinese Medicine Science and Technology Project,No.2021061;the Natural Science Foundation of Hunan Province,No.2025JJ80080。
BACKGROUND Injury to the glomerular filtration barrier causes diabetic kidney disease(DKD),and glomerular endothelial-mesenchymal transition damages the filtration barrier of glomerular endothelial cells.Shenfushu gra...
关键词：Diabetic kidney disease Glomerular filtration barrier GLYCOCALYX Shenfushu granules PIK3R1 Heparanase-1 Endothelial-mesenchymal transition 
Streamlined Agrobacterium rhizogenes-mediated hairy root transformation for efficient CRISPR/Cas9-based gene editing evaluation in diverse Citrullus cultivars
《Horticultural Plant Journal》2025年第2期816-826,共11页Yong Zhao Hongju Zhu Xuqiang Lu Muhammad Anees Nan He Dongdong Yang Zihao Chen Zonglie Hong Junhong Zhang Wenge Liu 
supported by the Basic Research Funds of Chinese Academy of Agricultural Sciences(Grant No.1610192023201);the National Key Research and Development Program of China(Grant No.SQ2023YFE0201239);China Agriculture Research System of MOF and MARA(Grant No.CARS-25-03);the Major Science and Technology Projects of Henan Province(Grant No.221100110400);the Funding of Joint Research on Agricultural Variety Improvement of Henan Province(Grant No.2022010503);the Agricultural Science and Technology Innovation Program(Grant No.CAAS-ASTIP-2021-ZFRI)。
The CRISPR/Cas9 genome-editing system serves as a pivotal tool for enhancing crop genetics.Within this system,single guide RNAs(sgRNAs)are instrumental in the precise cleavage of DNA double strands.However,the efficie...
关键词：Citrullus lanatus sgRNAs Agrobacterium rhizogenes Hairy root transformation CRISPR/Cas9 
STT3-mediated aberrant N-glycosylation of CD24 inhibits paclitaxel sensitivity in triple-negative breast cancer
《Acta Pharmacologica Sinica》2025年第4期1097-1110,共14页Jun Wang Hui-min Zhang Guan-hua Zhu Li-li Zhao Ji Shi Zhou-tong Dai Jia-peng Li Xing-rui Li Fan Sun Yuan Wu Shao-yong Chen Han-ning Li Xing-hua Liao Yuan Xiang 
financially supported by the National Natural Science Foundation of China(32170578 and 82203497);Hubei Natural Science Foundation(2024AFB905 and 2024AFD011);Hubei Province Key R&D Program(2022BCA007);Department of Education Scientific Research Program guidance project(B2023014);“The 14th Five Year Plan”Hubei Provincial advantaged characteristic disciplines(groups)project of Wuhan University of Science and Technology(2023C0303);Natural Science Foundation Exploration Program of Wuhan(2024040801020310);the Hunan Natural Science Foundation(2023JJ50310 and 2023JJ50296).
Paclitaxel is one of the main chemotherapic medicines against triple-negative breast cancer(TNBC)in clinic.However,it has been perplexed by paclitaxel resistance in TNBC patients,resulting in a poor prognosis.Abnormal...
关键词：triple-negative breast cancer PACLITAXEL CD24 N-GLYCOSYLATION ferroptosis STT3 
Plantamajoside mitigates endoplasmic reticulum stress-mediated pancreatic β-cell apoptosis in type 2 diabetes via DNAJC1 upregulation
《World Journal of Diabetes》2025年第4期318-325,共8页Md Abdul Alim Al-Bari Fabian Davamani Payal Bhatnagar Nabil Eid 
Diabetes mellitus(DM)is a metabolic disorder characterized by persistent hyperglycemia and other symptoms,which pose significant challenges to individual health,life expectancy,and public healthcare systems.The escala...
关键词：Plantamajoside Type 2 diabetes mellitus PI3K/AKT/NF-κB pathway Endoplasmic stress METFORMIN DNAJC1 Apoptosis AUTOPHAGY 
Pioneering rheumatoid arthritis treatment:Magnesium ionmediated natural multi-component hydrogel synergistically regulates macrophage polarization,pannus formation,and bone regeneration
《Nano Research》2025年第4期346-363,共18页Luping Yang Xiang Zhang Yihang Zhao Zhijia Wang Xinru Tan Yuxin Zhang Zhiwei Wang Jihui Lu Shuchang Yao Jingyi Jiao Xuemei Huang Penglong Wang 
funded by the National Natural Science Foundation of China(Nos.82274072 and 82474059);the Beijing Municipal Natural Science Foundation(Nos.7242221 and 7254503);Beijing Nova Programme Interdisciplinary Cooperation Project(No.20240484578);the Fundamental Research Funds for the Central Universities(China,Nos.2023-JYB-JBZD-049,2022-XJKYQD-008,and 2024-JYB-XJSJJ004);Beijing Key Laboratory for Basic and Development Research on Chinese Medicine(Beijing,No.100102).
Rheumatoid arthritis(RA)is a chronic inflammatory autoimmune disease that affects millions of people worldwide.Current therapeutic drugs for RA are often limited by poor solubility,unresponsive to monotherapy,low bioa...
关键词：magnesium ion-mediated natural multi-component hydrogel rheumatoid arthritis macrophages polarization PI3K/AKT/NF-κB signaling pathway 
Safener-mediated increase in yield components of common buckwheat
《The Crop Journal》2025年第2期597-606,共10页Qi Wang Yixin Wu Xinyue Lei Yaxin Li Xiaoyi Han Jiahao Ge Rong Zhong Jincai Tao Chenxi Wan Xiaoli Gao Pu Yang Jinfeng Gao 
supported by the Science and Technology Key Research&Development Project of Shaanxi Province(2022NY-178);the Technical System of Minor Cereals Industry in Shaanxi Province(NYKJ-2022-YL(XN)28);the Special Fund for Seed Industrial Development in Shaanxi Province(K3031223130).
Herbicide safeners alleviate herbicide toxicity while preserving weed-control efficacy in common buckwheat.A three-year field experiment was performed to measure the effects of quizalofop-P-ethyl(QPE)alone or in combi...
关键词：QUIZALOFOP-P-ETHYL Safeners Physiological characteristics Soil enzyme activities Common buckwheat growth and yield 
Targeting chaperone-mediated autophagy in neurodegenerative diseases:mechanisms and therapeutic potential
《Acta Pharmacologica Sinica》2025年第4期816-828,共13页Jin Wu Wan Xu Ying Su Guang-hui Wang Jing-jing Ma 
supported by the National Natural Science Foundation of China(grants 32400789 and 32070970);the Natural Science Foundation of Jiangsu Province(grants BK20240436);the Suzhou Science and Technology Development Plan(SZM2023006 and SKYD2023179);the Gusu Key Health Talent Program of Suzhou(GSWS2022122).
The pathological hallmarks of various neurodegenerative diseases including Parkinson’s disease and Alzheimer’s disease prominently feature the accumulation of misfolded proteins and neuroinflammation.Chaperone-media...
关键词：neurodegenerative diseases chaperone-mediated autophagy neuronal proteostasis NEUROINFLAMMATION CMA modulators 
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