Tauopathy promotes spinal cord-dependent production of toxic amyloid-beta in transgenic monkeys  

作　　者：Zhuchi Tu Sen Yan Bofeng Han Cajuan Li Weien Liang Yingqi Lin Yongyan Ding Huiyi Wei Lu Wang Hao Xu Jianmeng Ye Bang Li Shihua Li Xiao-Jiang Li 

机构地区：[1]Guangdong Key Laboratory of Non-human Primate Research,Key Laboratory of CNS Regeneration(Ministry of Education),GHM Institute of CNS Regeneration,Jinan University,Guangzhou 510632,China [2]Center of Cyclotron and PET Radiopharmaceuticals,Department of Nuclear Medicine and PET/CT-MRI Center,the First Affliated Hospital of Jinan University,Guangzhou 510630,China [3]Guangdong Landau Biotechnology Co.Ltd,Guangzhou 510555,China

出　　处：《Signal Transduction and Targeted Therapy》2023年第10期5023-5035,共13页信号转导与靶向治疗（英文）

基　　金：This work was supported by the Guangzhou Key Research Program on Brain Science(202007030008,202007030003);The National Natural Science Foundation of China(32170981,81830032,31872779,81922026,82071421,82171244);National Key Research and Development Program of China(2021YFA0805300,2021YFA0805200);Department of Science and Technology of Guangdong Province(2021ZT09Y007,2020B121201006);Key Field Research and Development Program of Guangdong province(2018B030337001).

摘　　要：Tauopathy,characterized by the hyperphosphorylation and accumulation of the microtubule-associated protein tau,and the accumulation of Aβ oligomers,constitute the major pathological hallmarks of Alzheimer's disease.However,the relationship and causal roles of these two pathological changes in neurodegeneration remain to be defined,even though they occur together or independently in several neurodegenerative diseases associated with cognitive and movement impairment.

关 键 词：PATHOLOGICAL CONSTITUTE MARKS 

分 类 号：R-332[医药卫生]