MUCIN

作品数:132被引量:365H指数:9
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相关作者:许焕丽王庆杰邵倩倩曲迅高文娟更多>>
相关机构:山东大学温州医科大学中国农业科学院学研究院更多>>
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Runchangningshen paste activates NLRP6 inflammasome-mediated autophagy to stimulate colonic mucin-2 secretion and modulates mucosal microbiota in functional constipation
《World Journal of Gastroenterology》2025年第9期100-134,共35页Xue-Jiao Liu Ye-li-ya Ye-er-tai Yue-Bo Jia Chen-Heng Wu Xiang-Xiang Wang Ke-Ming Yang Xuan Yao Jiang-Hong Ling 
Supported by National Natural Science Foundation of China,No.82174309;and Shanghai Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine Siming Fund Special Project for Scientific Research,No.SGKJ-202304.
BACKGROUND Runchangningshen paste(RCNSP)is a paste made of four medicinal and edible homologous Chinese medicine mixed with honey.It is known for its ability to nourish yin and blood as well as to loosen the bowel to ...
关键词:Traditional Chinese medicine Functional constipation NLRP6 AUTOPHAGY Mucosal microbiota MUCIN Goblet cells 
Relationship between gastric mucosal atrophy by endoscopy and non-ampullary duodenal epithelial tumors
《World Journal of Gastrointestinal Oncology》2025年第2期84-92,共9页Kazuya Ohno Eiji Nakatani Takafumi Kurokami Asami Kawai Ryosuke Itai Masanori Matsuda Yuichi Masui Tatsunori Satoh Shinya Ikeda Taiyo Hirata Shodai Takeda Makoto Suzuki Ken Haruma 
BACKGROUND The pathogenesis of non-ampullary duodenal epithelial tumors(NADETs)is not fully understood.NADETs that express gastric-type mucin phenotypes(GNADETs)are noteworthy because of their high malignancy.Gastric ...
关键词:Gastric acidity Gastric foveolar metaplasia Gastric mucosal atrophy Helicobacter pylori Mucin phenotype Nonampullary duodenal epithelial tumor 
Lactobacillus acidophilus FCQHC4L1 strengthens the intestinal mucus barrier and inhibits endoplasmic reticulum stress
《Food Science and Human Wellness》2025年第1期78-90,共13页Yuli Qi Leilei Yu Fengwei Tian Wei Chen Xiaoming Liu Qixiao Zhai 
funded by the Guangdong Province Key Research and Development Project(2022B111107006);the National Natural Science Foundation of China(32021005 and 31820103010);the Fundamental Research Funds for the Central Universities(JUSRP622013)。
Mucin 2(MUC2)is a critical component of the intestinal mucus barrier.Lactic acid bacteria(LAB)strains can improve mucosal homeostasis.In this study,we determined the expression of Muc2 induced by dead bacteria and cel...
关键词:MUCIN Probiotic Lactobacillus acidophilus Gut microbiota Endoplasmic reticulum(ER)stress 
Molecular mechanisms of bitterness and astringency in the oral cavity induced by soyasaponin
《Food Science and Human Wellness》2024年第6期3424-3433,共10页Lijie Zhu Yueying Pan Yingyan Li Yingjie Zhou He Liu Xiuying Liu 
supported by the Natural Science Foundation of Liaoning Province(2021-MS-311);National Natural Science Foundation of China(31601510).
The interaction mechanism between soyasaponin(Ssa)and bitter receptors/mucin,as well as the saliva interface behavior of Ssa,were investigated to explore the presentation mechanism of Ssa bitterness and astringency(BA...
关键词:SOYASAPONIN Bitterness and astringency Bitter taste receptor MUCIN 
Moxibustion inhibits the macrophage M1 polarization toll-like receptor 4/myeloid differentiation factor 88/nuclear factor kappa B signaling pathway by regulating T-cell immunoglobulin and mucin-containing protein-3 in rheumatoid arthritis
《Journal of Traditional Chinese Medicine》2024年第6期1227-1235,共9页LUO Kun ZHONG Yumei GUO Yanding ZHANG Linlin HU Danhui MA Wenbin YANG Xin ZHOU Haiyan 
the National Natural Science Foundation of China:Study on Immunoregulatory Mechanism of Moxibustion"Regulating Weiqi"to Regulate the Intrasynovial Environment Steady State in Rheumatoid Arthritis Model Rats based on the Skin-resident Memory T cells-Growth Arrest-specific 6/Mer Tyrosine Kinase (No. 82374587);the National Natural Science Foundation of China:Study on the Immune Mechanisms of Macrophage M1/M2 Polarization in the Treatment of Rheumatoid Arthritis by Moxibustion"Strengthening Body Resistance and Eliminating Evil"(No. 81973959);the National Key R&D Program of China:Research on the Functional Characteristics of"Special Effects"and"Common Effects"of Acupoints (No. 2019YFC1709001);Science and Technology Innovation Seedling Project of Sichuan Province:based on Macrophage M1 Polarization Signaling Pathway Toll-like receptor 4/Myeloid differentiation factor 88/Nuclear factor kappa B and its Regulatory Molecule T-cell Immunoglobulin and Mucin-containing Protein-3 Exploring the Effect Mechanism of Moxibustion on Experimental Rheumatoid Arthritis Model (No. 2022037)。
OBJECTIVE: To explore whether moxibustion exerts therapeutic effects on rheumatoid arthritis(RA) by regulating the expression of T-cell immunoglobulin and mucin-containing protein-3(TIM-3) and subsequently modulating ...
关键词:MOXIBUSTION ARTHRITIS RHEUMATOID TIM-3 macrophage polarization toll-like receptor 4 myeloid differentiation factor 88 nuclear factor kappa B signal transduction 
Cirsium japonicum mitigates allergic nasal inflammation by regulating NRF2-mediated mucin production: Systematic transcriptome and molecular docking analyses
《Journal of Pharmaceutical Analysis》2024年第10期1527-1530,共4页Bo-Jeong Pyun Su-Jin Baek Kyuhyung Jo Ik Soo Lee Musun Park Hye Jin Kim Joo Young Lee Susanna Choi Yun Hee Kim Taesoo Kim 
This work was supported by the Korea Institute of Oriental Medicine,Republic of Korea(Grant No.:KSN2023331).
Allergic rhinitis(AR)is an immunoglobulin(Ig)E-mediated allergic disease frequently recurring following seasonal changes and significantly impacting quality of life[1].Worsening AR symptoms can lead to more severe con...
关键词:ALLERGIC INFLAMMATION protective 
Abelmoschus manihot polysaccharide fortifies intestinal mucus barrier to alleviate intestinal inflammation by modulating Akkermansia muciniphila abundance被引量:1
《Acta Pharmaceutica Sinica B》2024年第9期3901-3915,共15页Yumeng Wang Chengxi Li Jianping Li Shu Zhang Qinyu Zhang Jinao Duan Jianming Guo 
the National Natural Science Foundation of China(82074136);High level key discipline construction project of the National Administration of Traditional Chinese Medicine-Resource Chemistry of Chinese Medicinal Materials(No.zyyzdxk-2023083,China).
The intestinal mucus barrier is an important line of defense against gut pathogens.Damage to this barrier brings bacteria into close contact with the epithelium,leading to intestinal inflammation.Therefore,its restora...
关键词:Plant polysaccharide Abelmoschus manihot Intestinal inflammation Mucus barrier Interleukin 10 Gut microbiota A.muciniphila Mucin 2 
Progress on immuno-microenvironment and immune-related therapies in patients with pseudomyxoma peritonei
《Cancer Biology & Medicine》2024年第7期586-605,共20页Qidi Zhao Tian Wei Ru Ma Yubin Fu Rui Yang Yandong Su Yang Yu Bing Li Yan Li 
supported by the General Program of the National Natural Science Foundation of China (Grant No. 82073376)。
Pseudomyxoma peritonei(PMP) is an indolent malignant syndrome. The standard treatment for PMP is cytoreductive surgery combined with intraperitoneal hyperthermic chemotherapy(CRS + HIPEC). However, the high recurrence...
关键词:Pseudomyxoma peritonei tumor immuno-microenvironment immune-related therapy mucin 2 GNAS mutation 
Establishment of a cholangiocarcinoma risk evaluation model based on mucin expression levels被引量:1
《World Journal of Gastrointestinal Oncology》2024年第4期1344-1360,共17页Chun-Yuan Yang Li-Mei Guo Yang Li Guang-Xi Wang Xiao-Wei Tang Qiu-Lu Zhang Ling-Fu Zhang Jian-Yuan Luo 
BACKGROUND Cholangiocarcinoma(CCA)is a highly malignant cancer,characterized by frequent mucin overexpression.MUC1 has been identified as a critical oncogene in the progression of CCA.However,the comprehensive underst...
关键词:MUCIN CHOLANGIOCARCINOMA Single-cell RNA sequencing Spatial transcriptomics PROGNOSIS 
Basis for the diversity and extent in loss of digestible nutrients created by dietary phytin:Emphasis on fowl and swine
《Animal Nutrition》2024年第1期422-428,共7页Edwin T.Moran Michael R.Bedford 
Phytin is the Ca^(2+)-Mg^(2+)-K^(+)salt of phytic acid that is created and deposited in the aleurone layer and/or germ of grains and legumes.Its high presence in feedstuffs for fowl and swine diets results in it being...
关键词:Digestive enzyme Calcium Endogenous protein MUCIN PHYTIN 
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