Abelmoschus manihot polysaccharide fortifies intestinal mucus barrier to alleviate intestinal inflammation by modulating Akkermansia muciniphila abundance  

作　　者：Yumeng Wang Chengxi Li Jianping Li Shu Zhang Qinyu Zhang Jinao Duan Jianming Guo 

机构地区：[1]Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization,Nanjing University of Chinese Medicine,Nanjing 210023,China [2]Jiangsu Key Laboratory for High Technology Research of TCM Formulae,Nanjing University of Chinese Medicine,Nanjing 210023,China

出　　处：《Acta Pharmaceutica Sinica B》2024年第9期3901-3915,共15页药学学报（英文版）

基　　金：the National Natural Science Foundation of China(82074136);High level key discipline construction project of the National Administration of Traditional Chinese Medicine-Resource Chemistry of Chinese Medicinal Materials(No.zyyzdxk-2023083,China).

摘　　要：The intestinal mucus barrier is an important line of defense against gut pathogens.Damage to this barrier brings bacteria into close contact with the epithelium,leading to intestinal inflammation.Therefore,its restoration is a promising strategy for alleviating intestinal inflammation.This study showed that Abelmoschus manihot polysaccharide(AMP)fortifies the intestinal mucus barrier by increasing mucus production,which plays a crucial role in the AMP-mediated amelioration of colitis.IL-10-deficient mouse models demonstrated that the effect of AMP on mucus production is dependent on IL-10.Moreover,bacterial depletion and replenishment confirmed that the effects of AMP on IL-10 secretion and mucus production were mediated by Akkermansia muciniphila.These findings suggest that plant polysaccharides fortify the intestinal mucus barrier by maintaining homeostasis in the gut microbiota.This demonstrates that targeting mucus barrier is a promising strategy for treating intestinal inflammation.

关 键 词：Plant polysaccharide Abelmoschus manihot Intestinal inflammation Mucus barrier Interleukin 10 Gut microbiota A.muciniphila Mucin 2 

分 类 号：R574[医药卫生—消化系统]