Progress on immuno-microenvironment and immune-related therapies in patients with pseudomyxoma peritonei  

作　　者：Qidi Zhao Tian Wei Ru Ma Yubin Fu Rui Yang Yandong Su Yang Yu Bing Li Yan Li 

机构地区：[1]School of Clinical Medicine,Tsinghua University,Beijing 100084,China [2]Department of Surgical Oncology,Beijing Tsinghua Changgung Hospital,School of Clinical Medicine,Tsinghua University,Beijing 102218,China [3]Department of Peritoneal Cancer Surgery,Bejing Shijitan Hospital,Capital Medical University,Bejing 100038,China

出　　处：《Cancer Biology & Medicine》2024年第7期586-605,共20页癌症生物学与医学（英文版）

基　　金：supported by the General Program of the National Natural Science Foundation of China (Grant No. 82073376)。

摘　　要：Pseudomyxoma peritonei(PMP) is an indolent malignant syndrome. The standard treatment for PMP is cytoreductive surgery combined with intraperitoneal hyperthermic chemotherapy(CRS + HIPEC). However, the high recurrence rate and latent clinical symptoms and signs are major obstacles to further improving clinical outcomes. Moreover, patients in advanced stages receive little benefit from CRS + HIPEC due to widespread intraperitoneal metastases. Another challenge in PMP treatment involves the progressive sclerosis of PMP cell-secreted mucus, which is often increased due to activating mutations in the gene coding for guanine nucleotide-binding protein alpha subunit(GNAS). Consequently, the development of other PMP therapies is urgently needed. Several immune-related therapies have shown promise, including the use of bacterium-derived non-specific immunogenic agents, radioimmunotherapeutic agents, and tumor cell-derived neoantigens, but a well-recognized immunotherapy has not been established. In this review the roles of GNAS mutations in the promotion of mucin secretion and disease development are discussed. In addition, the immunologic features of the PMP microenvironment and immune-associated treatments are discussed to summarize the current understanding of key features of the disease and to facilitate the development of immunotherapies.

关 键 词：Pseudomyxoma peritonei tumor immuno-microenvironment immune-related therapy mucin 2 GNAS mutation 

分 类 号：R735.5[医药卫生—肿瘤]