Exosomes in stroke management:A promising paradigm shift in stroke therapy  

作　　者：Bo Wang Pinzhen Chen Wenyan Li Zhi Chen 

机构地区：[1]Department of Neurosurgery,The First Hospital Affiliated to Army Medical University,Chongqing,China [2]Department of Radiology,The First Hospital Affiliated to Army Medical University,Chongqing,China

出　　处：《Neural Regeneration Research》2026年第1期6-22,共17页中国神经再生研究(英文版)

基　　金：supported by the Natural Science Foundation of Chongqing,No.CSTB2023NSCQ-mSX0561(to WL).

摘　　要：Effective treatment methods for stroke,a common cerebrovascular disease with a high mortality rate,are still being sought.Exosome therapy,a form of acellular therapy,has demonstrated promising efficacy in various diseases in animal models;however,there is currently insufficient evidence to guide the clinical application of exosome in patients with stroke.This article reviews the progress of exosome applications in stroke treatment.It aims to elucidate the significant potential value of exosomes in stroke therapy and provide a reference for their clinical translation.At present,many studies on exosome-based therapies for stroke are actively underway.Regarding preclinical research,exosomes,as bioactive substances with diverse sources,currently favor stem cells as their origin.Due to their high plasticity,exosomes can be effectively modified through various physical,chemical,and genetic engineering methods to enhance their efficacy.In animal models of stroke,exosome therapy can reduce neuroinflammatory responses,alleviate oxidative stress damage,and inhibit programmed cell death.Additionally,exosomes can promote angiogenesis,repair and regenerate damaged white matter fiber bundles,and facilitate the migration and differentiation of neural stem cells,aiding the repair process.We also summarize new directions for the application of exosomes,specifically the exosome intervention through the ventricular-meningeal lymphatic system.The review findings suggest that the treatment paradigm for stroke is poised for transformation.

关 键 词：angiogenesis animal model cerebrovascular disorder extracellular vesicle mortality rates neural stem cell NEUROINFLAMMATION oxidative stress programmed cell death therapy 

分 类 号：R73[医药卫生—肿瘤]