supported by Chinese Academy of Medical Sciences(CAMS)Innovation Fund for Medical Sciences(2022-I2M-2-002,2021-I2M-1-016,and 2022-I2M-1-014,China);the Beijing Outstanding Young Scientist Program(BJJWZYJH01201910023028,China);Chinese Academy of Medical Sciences(CAMS)Central Public-interest Scientific Institution Basal Research Fund(2018PT35004,Molecular Mechanism and Target Discovery of Metabolic Disorder and Tumorigenesis,CAMS Key Laboratory).
Zhigancao decoction is a traditional prescription for treating irregular pulse and palpitations in China.As the monarch drug of Zhigancao decoction,the bioactive molecules of licorice against heart diseases remain elu...
supported by the National Natural Science Foundation of China(82173808,U21A20419,82270500);Natural Science Foundation of Guangdong Province(2021B1515020100,China);Guangzhou Basic and Applied Basic Research Project(202206080007,China);Local Innovative and Research Teams Project of Guangdong Pearl River Talents Program(2017BT01Y093,China);Guangdong Provincial Key Laboratory of Construction Foundation(2017B030314030,China);Academic promotion program of Shandong First Medical University(2019LJ003,China).
The clinical utilization of doxorubicin(Dox)in various malignancies is restrained by its major adverse effect:irreversible cardiomyopathy.Extensive studies have been done to explore the prevention of Dox cardiomyopath...