子宫内膜癌组织TFRC表达及其预后价值  

TFRC Expression in Endometrial Cancer Tissues and Its Prognostic Value

作　　者：米婷婷 张裕民 张维娜[2] 张萍[2] 

机构地区：[1]青岛大学青岛医学院,山东 青岛 [2]青岛市市立医院妇科,山东 青岛 [3]菏泽市食品药品检验检测研究院质量科,山东 菏泽

出　　处：《临床医学进展》2025年第2期163-170,共8页Advances in Clinical Medicine

基　　金：青岛市自然科学基金(23-2-1-187-zyyd-jch);山东省医学会临床科研资金(YXH2022ZX02155)。

摘　　要：目的:探讨转铁蛋白受体(TFRC)在子宫内膜癌及癌旁组织中的表达、临床病理特征及预后价值。方法:以青岛市市立医院接受手术治疗的50例子宫内膜癌患者术后收集的子宫内膜癌组织及癌旁组织制备的石蜡切片为研究样本,利用免疫组化技术来评估转铁蛋白受体(TFRC)和Bcl-2在这两类组织中的表达特征,分析TFRC表达水平与子宫内膜癌患者预后之间的关联。结果:转铁蛋白受体(TFRC)在50例子宫内膜癌样本中的阳性表达率为68%,而在对应的癌旁组织中,该比率降至36%,两组之间的表达差异显示出显著的统计学意义(P Objective: To investigate the expression, clinicopathological characteristics and prognostic value of transferrin receptor (TFRC) in endometrial cancer and paracancerous tissues. Methods: Paraffin sections of endometrial cancer tissues and paracancerous tissues collected from 50 endometrial cancer patients who underwent surgery in Qingdao Municipal Hospital were used as study samples, and immunohistochemistry was used to evaluate the expression characteristics of transferrin receptor (TFRC) and Bcl-2 in these tissues, and to analyze the correlation between the expression level of TFRC and the prognosis of patients with endometrial cancer. Results: The positive expression rate of transferrin receptor (TFRC) in 50 endometrial cancer tissue samples was 68%, while in the corresponding paracancerous tissues, the rate decreased to 36%, and the difference in expression between the two groups showed a statistically significant (P < 0.01), and the positive expression rate of Bcl-2 in 50 endometrial cancer tissue samples was 62%, while in the corresponding paracancerous tissues, the positive expression rate was 42%. The difference between the two groups was statistically significant (P < 0.05), and the expression of TFRC and BCl-2 in endometrial cancer tissues was significantly higher than that in paracarcinoma tissues, with a positive correlation between the two expressions

关 键 词：子宫内膜癌 转铁蛋白受体 BCL-2 预后 

分 类 号：R73[医药卫生—肿瘤]