CALYCOSIN

作品数：17被引量：130H指数：6
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相关领域：医药卫生更多>>
相关作者：王平梁逸曾更多>>
相关机构：大连医科大学中南大学南京中医药大学桂林医学院更多>>
相关期刊：《Acta Biochimica et Biophysica Sinica》《Journal of Traditional Chinese Medicine》《Intelligent Medicine》《Food Science and Human Wellness》更多>>
相关基金：国家自然科学基金广西壮族自治区自然科学基金辽宁省教育厅高等学校科学研究项目湖北省自然科学基金更多>>
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Calycosin improves atherosclerosis by reshaping the interaction between the gut microbiome and bile acid metabolism
《Food Science and Human Wellness》2025年第4期1369-1386,共18页Jiaqi Fu Donghua Yu Yuqin Liang Xin Gao Yunhe Shi Yu Wang Pingping Chen Fang Lu Shumin Liu 
supported by Heilongjiang Postdoctoral Program(ZHY2022-114);General program of Heilongjiang Province(LBHZ22251);Young Elite Scientists Sponsorship Program(2022-QNRC1-27)。
Calycosin,Astragali Radix most prominent ingredient,has drawn more attention as a result of its ability to treat atherosclerosis(AS).However,the mechanism of action has not been fully elucidated.We investigated the ef...
关键词：CALYCOSIN Atherosderosis Bile acid metabolism Gut microbiota 
Anti-hepatic carcinoma mechanisms of calycosin through targeting ferroptosis
《Intelligent Medicine》2023年第3期173-179,共7页Litao Nie Yimei Liao Rui Zhou Xiao Liang Xiaowei Wan Xin Li Min Su 
supported by the National Natural Science Foundation of Guangxi (Grant No.2020GXNSFBA159066).
Background Ferroptosis,a pathologic state induced by lipid-driven oxidative stress,is associated with the development of human cancers.Calycosin,a natural compound with antioxidant and anti-inflammatory activities,has...
关键词：Hepatic carcinoma Ferroptosis CALYCOSIN BIOINFORMATICS Pharmacologic target 
Calycosin attenuates the inflammatory damage of microglia induced by oxygen and glucose deprivation through the HMGB1/TLR4/NF-κB signaling pathway被引量：5
《Acta Biochimica et Biophysica Sinica》2023年第9期1415-1424,共10页Xiang Li Xin Yang Huiling Lu Wenbo Wang Le Cai Jian Chen Yong Wang 
supported by the grants from the National Natural Science Foundation of China(Nos.81860231 and 82260711);the Guangxi Natural Science Foundation(Nos.2018GXNSFAA050054 and 2018GXNSFAA294138);the Scientific Research Ability Enhancement Project for Young and Middle-aged Faculty of Guilin Medical University(No.20502018006).
Stroke seriously threatens human life and health worldwide,but only very few effective stroke medicines are currently available.Our previous studies have indicated that the phytoestrogen calycosin exerts neuroprotecti...
关键词：CALYCOSIN HMGB1/TLR4/NF-κB signaling pathway MICROGLIA oxygen and glucose deprivation NEUROINFLAMMATION 
Synergism of calycosin and bone marrow-derived mesenchymal stem cells to combat podocyte apoptosis to alleviate adriamycininduced focal segmental glomerulosclerosis被引量：1
《World Journal of Stem Cells》2023年第6期617-631,共15页Qiong-Dan Hu Rui-Zhi Tan Yuan-Xia Zou Jian-Chun Li Jun-Ming Fan Fahsai Kantawong Li Wang 
the National Natural Science Foundation of China(General Program),No.82205002;Science and Technology Project of Sichuan Province,No.2022YFS0621,No.21ZDYF0348,and No.2022NSFSC1459;Luzhou-Southwest Medical University Science and Technology Strategic Cooperation Project,No.2021LZXNYD-P04;Southwest Medical University of Affiliated Traditional Medicine Hospital Project,No.2022-CXTD-03.
BACKGROUND Bone marrow-derived mesenchymal stem cells(MSCs)show podocyte-protective effects in chronic kidney disease.Calycosin(CA),a phytoestrogen,is isolated from Astragalus membranaceus with a kidney-tonifying effe...
关键词：CALYCOSIN Mesenchymal stem cells Focal segmental glomerulosclerosis APOPTOSIS SMAD3 
Inhibitory effect of calycosin on breast cancer cell progression through downregulating lncRNA HOTAIR and downstream targets:HuR and IGF2BP1
《Acta Biochimica et Biophysica Sinica》2023年第2期225-236,共12页Yuhong Li Hui Miao Wei Wei Jing Tian Jian Chen 
This work was supported by the grants from the Natural Science Foundation of Guangxi(No.2019GXNSFFA245001);the Innovation Project of Guangxi Graduate Education(No.YCSW2022383)。
Breast cancer is the most commonly diagnosed cancer worldwide.Previously,we reported that calycosin,a typical isoflavone phytoestrogen,triggers apoptosis and is associated with lncRNA HOTAIR in the estrogen receptor(E...
关键词：lncRNA HOTAIR HUR IGF2BP1 CALYCOSIN breast cancer 
In-silico analysis reveals the core targets and mechanisms of CA028,a new derivative of calycosin,in the treatment of colorectal cancer
《Intelligent Medicine》2022年第3期127-133,共7页Feiying Yin Xing Zhang Yu Li Xiao Liang Rong Li Jian Chen 
the National Natural Science Founda-tion of China(Grant Nos.81973574,82174082,and 82060736);Guangxi Natural Science Foundation(Grant Nos.2019GXNSFFA245001 and 2018GXNSFAA281334);Innovation Project of Guangxi Graduate Education(Grant No.YCSW2021253).
Background Colorectal cancer(CRC)is a type of malignant gastroenteric tumors associated with a high mortal-ity rate worldwide.Calycosin,a natural phytoestrogen,possesses potent anti-cancer properties.We structurally m...
关键词：Colorectal cancer CALYCOSIN CA028 Networking pharmacology Function Mechanism 
Calycosin attenuates severe acute pancreatitis-associated acute lung injury by curtailing high mobility group box 1-induced inflammation被引量：6
《World Journal of Gastroenterology》2021年第44期7669-7686,共18页Chang-Ju Zhu Wan-Guang Yang De-Jian Li Yao-Dong Song San-Yang Chen Qiao-Fang Wang Yan-Na Liu Yan Zhang Bo Cheng Zhong-Wei Wu Zong-Chao Cui 
BACKGROUND Acute lung injury(ALI)is a common and life-threatening complication of severe acute pancreatitis(SAP).There are currently limited effective treatment options for SAP and associated ALI.Calycosin(Cal),a bioa...
关键词：Severe acute pancreatitis Acute lung injury CALYCOSIN Mouse model Highmobility group box 1 Nuclear factor-kappa B 
Systems pharmacology dissection of action mechanisms for herbs in osteoporosis treatment被引量：6
《Chinese Herbal Medicines》2021年第3期313-331,共19页Ying Huai Wen-juan Zhang Wei Wang Kai Dang Shan-feng Jiang Dan-ming Li Meng Li Qiang Hao Zhi-ping Miao Yu Li Ai-rong Qian 
supported by the National Natural Science Foundation of China under No.81901917 and No.31570940;the key grant BKJ17J004 and the Key Research and Development Project of Shaanxi Province under No.2018SF-363;China’s Post-doctoral Science Fund under No.2017M623249;the Fundamental Research Funds for the Central Universities under No.3102017OQD050。
Objective:Osteoporosis has become the biggest cause of non-fatal health issue.Currently,the limitations of traditional anti-osteoporosis drugs such as long-term ill-effects and drug resistance,have raised concerns tow...
关键词：asperosaponinⅥ betulinic acid CALYCOSIN HEDERAGENIN LUTEOLIN drug discovery osteoporosis SYSTEMS 
The cardiovascular protective effect and mechanism of calycosin and its derivatives被引量：6
《Chinese Journal of Natural Medicines》2020年第12期907-915,共9页PAN Li ZHANG Xuan-Fen WEI Wan-Sheng ZHANG Jing LI Zhen-Zhen 
Cardiovascular disease is the main cause of mortality and morbidity in the world,especially in developing countries.Drug therapy is one of the main ways to treat cardiovascular diseases.Among them,great progress has b...
关键词：Cardiovascular disease CALYCOSIN Cadiac myocytes Vascular endothelial cells Protective effect 
Study on Pharmacological Effects of Calycosin in Astragali Radix被引量：3
《Medicinal Plant》2020年第2期38-40,43,共4页Yu ZHANG Tong ZHANG Shinong WANG Yannan LI Hui XUE Wenbo ZUO Chenghao JIN 
the Heilongjiang Farms&Land Reclamation Administration Support Project for Key Scientific Research(HKKYZD190705);The Heilongjiang Bayi Agricultural University Support Program for"San Zong"(TDJH201905);Heilongjiang Touyan Innovation Team Program(2019HTY078).
Calycosin is an important isoflavone compound in traditional Chinese medicine Astragali Radix.It not only has remarkable anti-oxidation,anti-inflammatory and anti-tumor functions,but also has the characteristics of sm...
关键词：CALYCOSIN PHARMACOLOGICAL EFFECT ANTI-OXIDATION ANTI-INFLAMMATORY ANTI-TUMOR 
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