PHARMACOLOGICAL

作品数：470被引量：1309H指数：18
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相关机构：北京大学华中农业大学华中科技大学中国药科大学更多>>
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Pharmacological targeting cGAS/STING/NF-κB axis by tryptanthrin induces microglia polarization toward M2 phenotype and promotes functional recovery in a mouse model of spinal cord injury
《Neural Regeneration Research》2025年第11期3287-3301,共15页Ziwei Fan Mengxian Jia Jian Zhou Zhoule Zhu Yumin Wu Xiaowu Lin Yiming Qian Jiashu Lian Xin Hua Jianhong Dong Zheyu Fang Yuqing Liu Sibing Chen Xiumin Xue Juanqing Yue Minyu Zhu Ying Wang Zhihui Huang Honglin Teng 
supported by the National Natural Science Foundation of China,Nos.82071387(to HT),81971172(to YW);the Natural Science Foundation of Zhejiang Province,China,No.LY22H090012(to HT);the Basic Research Project of Wenzhou City,China,No.Y20220923(to MZ)。
The M1/M2 phenotypic shift of microglia after spinal cord injury plays an important role in the regulation of neuroinflammation during the secondary injury phase of spinal cord injury.Regulation of shifting microglia ...
关键词：cGAS/STING functional recovery MICROGLIA neuroinflammation neuroprotection nuclear factor-κB POLARIZATION spinal cord injury TRYPTANTHRIN 
Enhancing the outcomes of diabetic vitrectomy with pharmacological adjuvants
《World Journal of Methodology》2025年第2期15-20,共6页Chun-Yao Cheng Wen-Rui Hao Tzu-Hurng Cheng 
This editorial offers insights from a minireview by Venkatesh et al,who explored pharmacological adjuvants for diabetic vitrectomy.Specifically,they synthesized current knowledge and evaluated the efficacy of various ...
关键词：Diabetic vitrectomy Pharmacological adjuvants Surgical outcomes Diabetic retinopathy Clinical implications 
Pharmacological intervention for chronic phase of spinal cord injury
《Neural Regeneration Research》2025年第5期1377-1389,共13页Chihiro Tohda 
Spinal cord injury is an intractable traumatic injury. The most common hurdles faced during spinal cord injury are failure of axonal regrowth and reconnection to target sites. These also tend to be the most challengin...
关键词：axonal growth chronic phase clinical study PHARMACOTHERAPY spinal cord injury 
Pharmacological role of Herba Patriniae and Coix seed in colorectal cancer
《World Journal of Gastrointestinal Oncology》2025年第3期1-8,共8页Yu-Xin Zhang Hui Wan Guan-Yue Shan Jun-Ya Cheng Yi-Ying Liu Wen-Na Shi Hai-Jun Li 
National Natural Science Foundation of China,No.81970529;The Natural Science Foundation of Jilin Province,No.20230508074RC and No.YDZJ202401218ZYTS.
Colorectal cancer(CRC)is the most prevalent cancer globally,and its traditional treatment modalities commonly encompass radiation therapy,chemotherapy,surgery and the administration of cytotoxic drugs.Currently,novel ...
关键词：Colorectal cancer Herba Patriniae Coix seed ANTITUMOR Chinese medicine 
Advances in management strategies for enteral nutrition-related gastric retention in adult patients with nasogastric tubes
《World Journal of Gastrointestinal Surgery》2025年第3期38-46,共9页Li-Fei Feng Xiang-Wei Li Xiao-Qiu Zhu Lin-Na Jin 
Supported by Zhejiang Province Medical and Health Technology Planning Project,No.2019332856.
Gastric retention is a common complication in individuals receiving enteral nutrition(EN)via a nasogastric tube,increasing the risk of aspiration pneumonia and causing unnecessary interruptions in nutritional support....
关键词：Enteral nutrition Gastric retention Management strategies Gastric residual volume Bedside ultrasound General intervention Pharmacological intervention Traditional Chinese medicine 
Effect of pharmacological pupil changes on intraocular lens power calculation:a systematic review and Metaanalysis
《International Journal of Ophthalmology(English edition)》2025年第3期518-525,共8页Si-Yi Tan Dian-Feng Liu Wei-Qi Wang Bing-Song Wang 
Supported by Beijing Natural Science Foundation from Beijing Municipal Government(No.7202030).
AIM:To investigate the effect of pharmacological pupil alterations on intraocular lens(IOL)power calculations.METHODS:A systematic review and Meta-analysis of studies published before December 2023 in the PubMed,Embas...
关键词：ocular biometry intraocular lens power calculation CATARACT pharmacological pupil alterations 
Review on the research progress into the traditional Chinese medicinal Jing Fang granules:chemical composition,pharmacological effects and clinical applications
《Integrative Medicine Discovery》2025年第6期1-13,共13页Rui Zhao Tai-Li Zhao Hong-Hua Li Pei-Pei Zhao Meng-Meng Wang Yi-Wei Meng Jing-Li Ren Xin Yin Jing-Chun Yao 
supported by the Key R&D Program of Shandong Province,China(No.2024TZXD067,2022SFGC0105);Natural Science Foundation of Shandong Province(No.ZR2023QB021);Young Taishan Scholarship to Xuekui Xia(No.tsqn202103100);Jinan Talent Project for Universities(No.2021GXRC062,202228088);Key innovation Project and Science,Education and Industry Integration Innovation Pilot Project of Qilu University of Technology(Shandong Academy of Sciences)(No.2022JBZ01-06,2024ZDZX03,2023RCKY214).
Jing Fang granules(JFG)are a modern Chinese medicinal formulation derived from Jing Fang Defeating Toxin San(JFDS).JFG primarily contains bioactive compounds such as flavonoids/flavonoid glycosides,coumarins and other...
关键词：chemical composition clinical application Jing Fang granules pharmacological effect traditional Chinese herbal formula 
Metabolomics as an emerging tool for the pharmacological and toxicological studies on Aconitum alkaloids
《Chinese Journal of Natural Medicines》2025年第2期182-190,共9页Han Ding Yamin Liu Sifan Wang Yuqi Mei Linnan Li Aizhen Xiong Zhengtao Wang Li Yang 
supported by the National Natural Science Foundation of China (No.82274223)。
Aconitum(Ranunculaceae)has a long-standing history in traditional Chinese medicine(TCM),where it has been widely used to treat conditions such as rheumatoid arthritis(RA),myocardial infarction,and heart failure.Howeve...
关键词：Metabolomics Aconitum alkaloids Biomarkers METABOLITES Metabolic pathway 
Advances in understanding prevention and treatment of alzheimer’s disease:A comprehensive review
《遵义医科大学学报》2025年第1期77-97,共21页Surendra Sarsaiya Liu Bo Archana Jain Pan Hong Shi Jingshan 
国家自然科学基金资助项目(NO:U1812403)。
Objective Alzheimer’s disease(AD)presents a significant global health challenge with a steadily increasing prevalence and impact.This comprehensive review aimed to delve into the epidemiology,pathophysiology,pharmaco...
关键词：alzheimer’s disease EPIDEMIOLOGY PATHOPHYSIOLOGY pharmacological therapies treatment prevention 
Chinese Medicine for Treatment of COVID-19:A Review of Potential Pharmacological Components and Mechanisms
《Chinese Journal of Integrative Medicine》2025年第1期83-95,共13页XU Qian-qian YU Dong-dong FAN Xiao-dan CUI He-rong DAI Qian-qian ZHONG Xiao-ying ZHANG Xin-yi ZHAO Chen YOU Liang-zhen SHANG Hong-cai 
Supported by the State Administration of Traditional Chinese Medicine(No.GZY-KJS-2021-055)。
Coronavirus disease 2019(COVID-19)is an acute infectious respiratory disease that has been prevalent since December 2019.Chinese medicine(CM)has demonstrated its unique advantages in the fight against COVID-19 in the ...
关键词：Chinese medicine COVID-19 SARS-CoV-2 substance component mechanism experimental method 
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