TRYPTANTHRIN

作品数：4被引量：7H指数：2
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相关领域：医药卫生更多>>
相关作者：刘小卒更多>>
相关机构：遵义医学院更多>>
相关期刊：《广东化工》《Cellular & Molecular Immunology》《Acta Pharmacologica Sinica》《Neural Regeneration Research》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划更多>>
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Pharmacological targeting cGAS/STING/NF-κB axis by tryptanthrin induces microglia polarization toward M2 phenotype and promotes functional recovery in a mouse model of spinal cord injury
《Neural Regeneration Research》2025年第11期3287-3301,共15页Ziwei Fan Mengxian Jia Jian Zhou Zhoule Zhu Yumin Wu Xiaowu Lin Yiming Qian Jiashu Lian Xin Hua Jianhong Dong Zheyu Fang Yuqing Liu Sibing Chen Xiumin Xue Juanqing Yue Minyu Zhu Ying Wang Zhihui Huang Honglin Teng 
supported by the National Natural Science Foundation of China,Nos.82071387(to HT),81971172(to YW);the Natural Science Foundation of Zhejiang Province,China,No.LY22H090012(to HT);the Basic Research Project of Wenzhou City,China,No.Y20220923(to MZ)。
The M1/M2 phenotypic shift of microglia after spinal cord injury plays an important role in the regulation of neuroinflammation during the secondary injury phase of spinal cord injury.Regulation of shifting microglia ...
关键词：cGAS/STING functional recovery MICROGLIA neuroinflammation neuroprotection nuclear factor-κB POLARIZATION spinal cord injury TRYPTANTHRIN 
天然产物Tryptanthrin和Phaitanthrin A的全合成研究
《广东化工》2018年第13期284-285,共2页刘小卒 杨思倚 
以邻氨基苯甲酸为原料,通过酰氯化、与吲哚生成酰胺以及氢化还原合成了关环前体(2-氨基苯)(1H-吲哚)甲酮。以丙酮为溶剂,四丁基碘化铵为催化剂,过氧叔丁醇为氧化剂,冰醋酸为添加剂的条件下,(2-氨基苯)(1H-吲哚)甲酮发生串联反应生成色胺...
关键词：色胺酮 天然产物全合成 串联反应 一锅煮反应 催化反应 
Cytotoxicity and reversal of multidrug resistance by tryptanthrin-derived indoloquinazolines被引量：2
《Acta Pharmacologica Sinica》2010年第2期259-264,共6页Sung-tsai YU Ji-wang CHERN Tzer-ming CHEN Yi-fan CHIU Hui-ting CHEN Yen-hui CHEN 
Aim： To evaluate the effects and elucidate the mechanisms of a series of indoloquinazolines as novel anticancer agents. Methods： Condensation of the substituted isatoic anhydride with the substituted isatin was perf...
关键词：apoptosis CYTOTOXICITY drug resistance MCF-7 TRYPTANTHRIN 
Modulatory Effects and Action Mechanisms of Tryptanthrin on Murine Myeloid Leukemia Cells被引量：6
《Cellular & Molecular Immunology》2009年第5期335-342,共8页Hoi-Ling Chan Hon-Yan Yip Nai-Ki Mak Kwok-Nam Leung 
Leukemia is the disorder of hematopoietic cell development and is characterized by an uncoupling of cell proliferation and differentiation. There is a pressing need for the development of novel tactics for leukemia th...
关键词：Ban-Lan-Gen TRYPTANTHRIN myeloid leukemia cell differentiation 
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