Early Postnatal Pharmacological Intervention Rescues the Disruption of Developmental Connectivity in MAO-A KO Mice  

作　　者：Qian Xue Hanpeng Xu Muye Zhu Bin Qian Lei Gao Lin Gou Houri Hintiryan Jean C.Shih Hong-Wei Dong 

机构地区：[1]Department of Pharmacology and Pharmaceuticals Sciences,Mann School of Pharmacy,University of Southern California,Los Angeles,CA,90033,USA [2]Department of Neurobiology,David Geffen School of Medicine,University California Los Angeles,Los Angeles,CA,90089,USA [3]of Integrative Anatomical Sciences,Keck School of Medicine,University of Southern California,Los Angeles,CA,90032,USA

出　　处：《Neuroscience Bulletin》2025年第2期339-343,共5页神经科学通报(英文版)

基　　金：support JCS,QX,and BQ,as well as covering all experimental and material costs for this project,NIH/NIMH R01 MH094360-06(HWD)grant to support HX,MZ,Lei Gao,Lin Gou,HH and HWD.

摘　　要：Dear Editors,The term“developmental disconnection syndromes”(DDSs)was first coined by Geshwind and Levitt in 2007[1]to describe the weakening of already formed connections or an absence of certain connections to establish correct organization de novo in early developmental stages.DDSs include a number of neuropsychiatric diseases,such as autistic spectrum disorder(ASD)[1,2],which is characterized by impaired social communication and repetitive and stereotyped behaviors.Nevertheless,the exact etiology underlying these“disconnections”and their abnormal developmental trajectory remains largely unclear.Even less known is whether developmental disconnections relevant to autism can be rescued by early intervention thereby preventing neuropsychiatric and repetitive symptoms in later stages.This study addresses these important questions.

关 键 词：impaired social communication Developmental Disconnection Syndromes Neuropsychiatric Diseases Early Postnatal disconnection syndromes ddss Pharmacological Intervention MAOA KO Mice weakening already formed connections 

分 类 号：R749.94[医药卫生—神经病学与精神病学]