Acquired sensorineural hearing loss,oxidative stress,and microRNAs  

作　　者：Desmond A.Nunez Ru C.Guo 

机构地区：[1]Division of Otolaryngology–Head&Neck Surgery,Department of Surgery,Faculty of Medicine,The University of British Columbia,Vancouver,BC,Canada [2]Division of Otolaryngology–Head&Neck Surgery,Gordon&Leslie Diamond Health Care Centre,Vancouver General Hospital,Vancouver,BC,Canada [3]Faculty of Medicine–The University of British Columbia,Vancouver,BC,Canada

出　　处：《Neural Regeneration Research》2025年第9期2513-2519,共7页中国神经再生研究（英文版）

摘　　要：Hearing loss is the third leading cause of human disability.Age-related hearing loss,one type of acquired sensorineural hearing loss,is largely responsible for this escalating global health burden.Noise-induced,ototoxic,and idiopathic sudden sensorineural are other less common types of acquired hearing loss.The etiology of these conditions is complex and multi-fa ctorial involving an interplay of genetic and environmental factors.Oxidative stress has recently been proposed as a likely linking cause in most types of acquired sensorineural hearing loss.Short non-coding RNA sequences known as microRNAs(miRNAs)have increasingly been shown to play a role in cellular hypoxia and oxidative stress responses including promoting an apoptotic response.Sensory hair cell death is a central histopathological finding in sensorineural hearing loss.As these cells do not regenerate in humans,it underlies the irreversibility of human age-related hearing loss.Ovid EMBASE,Ovid MEDLINE,Web of Science Core Collection,and ClinicalTrials.gov databases over the period August 1,2018 to July 31,2023 were searched with"hearing loss,""hypoxamiRs,""hypoxia,""microRNAs,""ischemia,"and"oxidative stress"text words for English language primary study publications or registered clinical trials.Registe red clinical trials known to the senior author we re also assessed.A total of 222studies were thus identified.After excluding duplicates,editorials,retra ctions,secondary research studies,and non-English language articles,39 primary studies and clinical trials underwent full-text screening.This resulted in 11 animal,in vitro,and/or human subject journal articles and 8 registered clinical trial database entries which form the basis of this narrative review.MiRNAs miR-34a and miR-29b levels increase with age in mice.These miRNAs were demonstrated in human neuroblastoma and murine cochlear cell lines to target Sirtuin 1/peroxisome proliferato r-activated receptor gamma coactivator-1-alpha(SIRT1/P GC-1α),SIRT1p53,and SIRT1/hypoxia-inducible factor 1-alpha

关 键 词：hearing loss HYPOXIA MICRORNAS oxidative stress SENSORINEURAL 

分 类 号：R764.431[医药卫生—耳鼻咽喉科]