Inside help for brain tumors: macrophage-mediated myelin recycling promotes cell state-specific glioblastoma progression  

作　　者：Antonio C.Pagano Zottola Thomas Daubon Varun Venkataramani 

机构地区：[1]University of Bordeaux,INSERM,U1312 BRIC,Pessac,France [2]University of Bordeaux,CNRS,IBGC UMR 5095,Bordeaux,France [3]Neurology Clinic and National Center for Tumor Diseases,University Hospital Heidelberg,Heidelberg,Germany

出　　处：《Signal Transduction and Targeted Therapy》2025年第1期1-2,共2页信号转导与靶向治疗(英文)

摘　　要：In a recent paper published in Cell, Kloosterman et al. uncovered how lipid-laden macrophages in brain tumor called glioblastomas engage in myelin recycling, demonstrating that these cells process myelin debris into lipid resources that fuel the growth of mesenchymal-like glioblastoma cells while simultaneously maintaining an immunosuppressive microenvironment1 (Fig. 1). This finding suggests a promising therapeutic strategy, as pharmacological inhibition of lipid uptake through CD36 blockade improved survival in preclinical models and could potentially enhance the efficacy of existing treatments, including immunotherapy.

关 键 词：MYELIN CD36 GLIOBLASTOMA 

分 类 号：R73[医药卫生—肿瘤]