Nanoscale“precision strike”:Tumor microenvironment-responsive smart micelles for efficient targeted drug delivery  

作　　者：Dong Wan Yarong Song Xiujuan Lu Yanfeng Huang Jianxin Zhang Yonghui Liu Yi Liu Jie Pan 

机构地区：[1]School of Chemistry,Tiangong University,Tianjin 300387,China [2]School of Chemical Engineering and Technology,Tiangong University,Tianjin 300387,China

出　　处：《Nano Research》2024年第9期8360-8367,共8页纳米研究（英文版）

基　　金：financial support from National Natural Science Foundation of China(Nos.22178270,22078246,82103984,and U23A2089).

摘　　要：To address the limitations of conventional nanotechnology-based drug delivery systems,this work developed enzyme and reduction dual-responsive polymeric micelles.These micelles were synthesized with copolymers composed of TPGS_(3350)-PVGLIG-DOX(TPD)and FA-SS-DOX(FSD),which endow them with tumor-targeted drug delivery capabilities.TPGS_(3350)contributes to extending the circulation of micelles in body,augmenting their accumulation in tumor tissues via the enhanced permeability and retention(EPR)effect.Upon localized the tumor site,matrix metalloproteinase 2(MMP2)cleaves the PVGLIG peptide moiety within the micelles,thereby releasing TPGS_(3350)and exposing the targeting ligand of folate.This approach enables the subsequent internalization of the micelles by tumor cells through folate receptor-mediated endocytosis.After internalization,the high intracellular concentration of glutathione(GSH)triggers the reduction of the disulfide bond within the FA-SS-DOX,leading to the release of the anticancer-drug doxorubicin(DOX),which promotes apoptosis in the tumor cells and enhances the efficacy of chemotherapy.

关 键 词：CANCER PEPTIDE MICELLE dual-responsive folate 

分 类 号：TB383[一般工业技术—材料科学与工程]