Psoriasis,metabolic syndrome and methotrexate:Is this association suitable for a new subcategory in steatotic liver disease?  

作　　者：Luciana Agoglia Maria Chiara Chindamo Cristiane Villela-Nogueira 

机构地区：[1]Department of Internal Medicine,School of Medicine,Section of Gastroenterology,Hospital Universitário Antônio Pedro,Federal University Fluminense,Niterói 24033-900,Rio de Janeiro,Brazil [2]Department of Internal Medicine,School of Medicine and Hepatology Division,Hospital Universitário Clementino Fraga Filho,Federal University of Rio de Janeiro,Rio de Janeiro 21941-913,Brazil

出　　处：《World Journal of Hepatology》2025年第4期11-18,共8页世界肝病学杂志(英文)

摘　　要：Psoriasis is a prevalent inflammatory disease that shares chronic inflammation pathways with the pathophysiology of metabolic syndrome(MetS),type-2 diabetes mellitus and atherosclerosis.A high prevalence of steatosis and advanced liver fibrosis has been described in psoriasis.The influence of MetS and its compounds,patatin-like phospholipase domain containing 3 and transmembrane 6 superfamily member 2 gene polymorphisms and the cumulative dose of methotrexate(MTX)in the progression of steatotic disease are still under debate.A suitable new classification for psoriasis-related liver disease,under the umbrella of steatotic liver disease(SLD),might be evaluated due to the potential impact of MTX on liver steatosis.Considering the interplay between the MetS,steatosis and MTX,a new definition for this complex disease might be discussed since it is not entirely addressed under the umbrella of SLD and metabolic-dysfunction associated SLD.Hence,shortly,a discussion could be raised on the feasible term“Met-Drug SLD”,metabolic and drug-induced SLD,which comprises both metabolic dysfunction and drug-related SLD.This review aims to report the best evidence to accurately classify liver disease in psoriasis,considering the new definition of SLD,allowing appropriate management once it is carefully defined.

关 键 词：PSORIASIS Genetic polymorphisms METHOTREXATE Metabolic dysfunctionassociated steatotic liver disease Liver fibrosis Transient elastography 

分 类 号：R575[医药卫生—消化系统]