Science and Technology Key Project of Xuzhou Municipal Health Commission,Jiangsu Province,China(XWKYHT20210531);Pengcheng Yingcai-Medical Young Reserve Talent Programme(XWRCHT20220013).
Objective:To investigate whether angiotensinⅡtype 1 receptor(AGTR1 A1166C)gene polymorphism was associated with the effectiveness of valsartan monotherapy in Chinese patients with essential hypertension.Methods:This ...
Objective To evaluate the efficacy and safety of sacubitril-valsartan (SV) in reducing blood pressure in patients with non-dialysis-dependent chronic kidney disease(NDD-CKD) stage 3-5 and concomitant hypertension.
supported by the First People’s Hospital of Lianyungang Talent Fund(QN202003);the Research and Development Fund of Kangda College of Nanjing Medical University(KD2022KYJJZD068).
Objective:The risk of acute kidney injury(AKI)is high in patients with acute decompensated heart failure(ADHF).The aim of this study is to analyze the role of urinary neutrophil gelatinase-associated lipocalin(uNGAL)i...
Supported by National Natural Science Foundation of China(81774229);Nanjing Chinese Medicine Young Talent Cultivation Program(ZYQ20027);Natural Science Foundation of Nanjing University of Chinese Medicine(XZR2021052);Discipline(Academic)Reserve Talent Training Program of Nanjing Hospital of Chinese Medicine(YRC2016-CZL);Nanjing Traditional Chinese Medicine Science and Technology Special Fund Project(ZYQN202203);Traditional Chinese Medicine Preparation Research Project in Nanjing Medical Institutions(NJCC-ZJ-202315).
[Objectives]To observe the effect of Guanxin-V Mixture combined with Sacubitril Valsartan on cardiac function in patients after PCI for acute ST-segment elevation myocardial infarction(STE-MI).[Methods]41 cases of STE...
Objective:To investigate the effectiveness and efficiency of combining levamlodipine besylate and valsartan in the treatment of hypertension.Methods:This study selected 28 patients with hypertension as observation sub...
supported by the National Natural Science Foundation of China(No.81873516&No.821704-63);the National Key Research and Development Program of China(2021YFF0501404&2021YFF0501403&2017YFC1308303);the Natural Science Foundation of Shandong Province(ZR2019PH030&ZR2019BH052);the China International Medical Foundation(Z-2019-42-1908-2).
BACKGROUND It is not clear whether sacubitril/valsartan is beneficial for patients with heart failure(HF)with reduced ejec-tion fraction(HFrEF)and low systolic blood pressure(SBP).This study aimed to investigate the e...
National Natural Science Foundation of China (No.81803925);National Key Research and Development Program (No.2017YFC1700102)。
Objective:To systematically evaluate the clinical efficacy of oral Chinese patent medicine combined with sacubitril/valsartan in treating chronic heart failure(CHF).Methods:CNKI,CSPD,CCD,CBM,PubMed,Web of Science,Coch...
The authors thank the Shiyanjia Lab(www.shiyanjia.com)for TEM measurements.The authors are grateful to Ms.Xiao Guo at the Joint Live Small Animal Imaging Laboratory of Fudan University Shanghai Medical College-PerkinElmer Company,for her technical support with the use of the in vivo imaging system.This work was financially supported by the National Key Research and Development Program of China(No.2016YFC1301200);the National Natural Science Foundation of China(Nos.82070281,81870269,and 82170524);Shanghai Clinical Research Center for Interventional Medicine(No.19MC1910300).
Activation of the local renin-angiotensin system(RAS)promotes cardiomyocyte apoptosis and cardiac remodeling after acute myocardial infarction(AMI).As an anti-RAS drug,the effect of Valsartan in the early stage of acu...
With the launch of sacubitril/valsartan(ARNI),there are new options for the treatment of heart failure(HF).However,ARNI is currently only used in HF patients with reduced ejection fraction(HFrEF).No evidence shows tha...
Objective: To investigate the effect of sacubitril-valsartan combined with Zhenyuan capsule in the treatment of chronic heart failure comorbid anxiety and depression and its effect on the level of inflammatory factors...