AGTR1 A1166C gene polymorphism is associated with the effectiveness of valsartan monotherapy in Chinese patients with essential hypertension:A retrospective analysis  

作　　者：Hanzhong Yu Lei Li Shuyao Wei Qianqian Kong Wei Nu Bo Dong Yuewu Zhao Li Wang 

机构地区：[1]Department of Clinical Laboratory,the Affiliated Xuzhou Municipal Hospital of Xuzhou Medical University,Xuzhou,Jiangsu 221116,China [2]Department of Clinical Laboratory,Xuzhou Tumor Hospital,Xuzhou,Jiangsu 221005,China [3]Department of Cardiovascular Medicine,the Affiliated Xuzhou Municipal Hospital of Xuzhou Medical University,Xuzhou,Jiangsu 221116,China

出　　处：《Asian Pacific Journal of Tropical Medicine》2024年第9期418-424,共7页亚太热带医药杂志（英文版）

基　　金：Science and Technology Key Project of Xuzhou Municipal Health Commission,Jiangsu Province,China(XWKYHT20210531);Pengcheng Yingcai-Medical Young Reserve Talent Programme(XWRCHT20220013).

摘　　要：Objective:To investigate whether angiotensinⅡtype 1 receptor(AGTR1 A1166C)gene polymorphism was associated with the effectiveness of valsartan monotherapy in Chinese patients with essential hypertension.Methods:This retrospective analysis included 198 patients(≥18 years of age)who received valsartan monotherapy(80 mg/day)for newly developed essential hypertension at the authors’center between January 1,2020 and December 31,2023.Genotyping for AGTR1 A1166C gene polymorphism was done by polymerase chain reaction(PCR)-melting curve analysis of genomic DNA from peripheral blood samples.A dominant genetic model for AGTR1 A1166C(AA genotype versus AC+CC genotype)was used.Multivariate regression analysis of baseline variables and AGTR1 polymorphism was conducted to identify predictors of target blood pressure attainment(<140/90 mmHg)at the 4-week follow-up.Results:The median age of the 198 patients was(53.7±13.5)years,and 58%were men.Genotyping assays showed that 164 patients had the AA genotype,and 34 patients were of the AC/CC genotype,including 30 with the AC genotype and 4 with the CC genotype.Allele distribution was consistent with Hardy Weinberg equilibrium.109 Patients(55.1%)attained the blood pressure target.Multivariate analysis showed that smoking(versus no smoking,HR 0.314,95%CI 0.159-0.619,P=0.001)and AGTR1 A1166C AA genotype(versus AC/CC,HR 2.927,95%CI 1.296-6.611,P=0.023)were significant and independent predictors of target attainment.25 Patients(73.5%)with AGTR1 A1166C AC/CC genotype attained the target versus 51.2%(51/164)of patients with AGTR1 A1166C AA genotype(P=0.017).Patients with AGTR1 A1166C AC/CC genotype had a significantly greater reduction in systolic blood pressure[(33.1±10.8)mmHg versus(29.2±11.7)mmHg in AA carriers;(P=0.029)].Conclusions:Hypertensive patients carrying one or two C alleles of the AGTR1 A1166C gene were more responsive to valsartan treatment.

关 键 词：Essential hypertension AngiotensinⅡtype 1 receptor antagonist VALSARTAN AGTR1 A1166C Gene polymorphism 

分 类 号：R544.1[医药卫生—心血管疾病]