supported by the First People’s Hospital of Lianyungang Talent Fund(QN202003);the Research and Development Fund of Kangda College of Nanjing Medical University(KD2022KYJJZD068).
Objective:The risk of acute kidney injury(AKI)is high in patients with acute decompensated heart failure(ADHF).The aim of this study is to analyze the role of urinary neutrophil gelatinase-associated lipocalin(uNGAL)i...
Supported by National Natural Science Foundation of China:Mechanism of Protective Effects of Moxibustion on Regulating m TOR Signaling Pathway and Inhibiting Autophagy in Rats(No.81574084);Key Research and Development Program of Anhui Province:Mechanism and Clinical Application of Moxibustion in that Treatment of Chronic Heart Failure(No.202004j07020045);Open Fund Project of Key Laboratory of Xin’an Medical Education Ministry:Effect of Moxibustion on Myocardial Cell Energy Metabolism in Chronic Heart Failure Patients Based on Xin’an Physician’s Theory of Strengthening the Foundation and Cultivating the Original(No.2020xayx07);Key Natural Science Projects of Anhui Provincial Education Department:Mechanism of Moxibustion Against CHF Fibrosis Based on mi R-21/PTEN/m TOR Signaling Pathway-mediated Regulation of Autophagy in Myocardial Cells by circ PAN3(No.KJ2021A0570)。
OBJECTIVE:To observe the effects of moxibustion at bilateral Feishu(BL13)and Xinshu(BL15)combined with benazepril on myocardial cells apoptosis index,the expression levels of apoptosis-related proteins cytochrome c(Cy...
Natural Science Foundation-funded Project:Role of HMGB-1-TLR4/RAGE Pathway Over-Expression in Increased Offspring's Pyelonephritis Sensitivity Induced by Pregnant Inflammatory Stimulation(No.81703522);the Role and Mechanisms of Decidual NK Cell Abnormality in Prenatal Inflammation-Induced Offspring's Immune System Dysfunction and Hypertension(No.81520108029);Role of AMPK/NK-ΚB Signal Pathway Imbalance in Offspring's Hypertension Induced by Pregnant Inflammatory Stimulation(No.81703521);Roles and Mechanisms of Mitochondrial Dyshomeostasis in the Hypersensitivity of Cardiac Damage Responding to Cardiac Risk Factors in Offspring of Prenatal Inflammatory Stimulation(No.81773742)。
OBJECTIVE:To assess the protective role of benazepril,an angiotensin-converting enzyme inhibitor,in renal damage caused by prenatal inflammation.METHODS:Saline or lipopolysaccharide were administered intraperitoneally...
Objective:To explore the protective effect of calcium dobesilate combined with benazepril therapy on renal injury in patients with early diabetic nephropathy and the possible molecular mechanisms.Methods:A total of 50...
A stability indicating LC method was developed for the simultaneous determination of Amlodipine and Benazepril capsules in pharmaceutical dosage form. Efficient chromatographic separation was achieved on Symmetry C18 ...
Background Combination therapy is an effective method to reduce the blood pressure (BP) for patients with hypertension.This study was performed to evaluate the efficacy and safety of benazepril/lercanidipine compare...
supported by grants from the Department of Public Health of Hubei Province of China (No. 2012Z-B08);the Health Bureau of Wuhan City of China (No. WX12C10)
Summary: This study investigated the effects of benazepril administered in the morning or evening on the diurnal variation of renin-angiotensin-aldosterone system (RAAS) and clock genes in the kidney. The male Wist...
Background The role of angiotensin-converting enzyme inhibitors (ACEI) in contrast-induced acute kidney injury (CI-AKI) is controversial. Some studies pointed out that it was effective in the prevention of CI-AKI,...
Background Marked interindividual variation exists in blood pressure response to benazepril, which is considered to have genetic basis. Our objectives were to evaluate whether the E112D polymorphism in the prolylcarbo...