Efficacy and safety of Nephritis rehabilitation tablet combined with Valsartan for chronic glomerulonephritis:A system review and metaanalysis  

作　　者：Qiao Liu Tai-Wei Dong Feng Gao Yan-Li Guo Feng Miao Pei-Feng Wei 

机构地区：[1]Shannxi University of Chinese Medicine,Xianyang 712000,China [2]The Second Affiliated Hospital of Shaanxi University of Chinese Medicine,Xianyang 712000,China

出　　处：《Journal of Hainan Medical University》2022年第8期36-44,共9页海南医学院学报（英文版）

基　　金：The Second Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine(No.2020XKTD-A04);Disciplinary Innovation Team Plan of Shaanxi University of Traditional Chinese Medicine(No.2019-QN02)。

摘　　要：Objective:To systematically evaluate the efficacy and safety of Nephritis Rehabilitation Tablet(NRT)combined with valsartan in treatment of chronic glomerulonephritis(CGN).Methods:Computer search databases such as CNKI,CBM,VIP,wanfang,Embase,PubMed and Cochrane library,and find all randomized controlled trials(RCTs)comparing NRT combined with valsartan versus valsartan in treatment of chronic glomerulonephritis.The search time limit is to build the database until October 2020.RCTs were screened according to the inclusion and exclusion criteria.After data extraction and quality assessment,the Cochrane risk of bias tool was used to evaluate the methodological quality of these studies.Meta-analysis was performed by Review Manager 5.2,and GRADE system for evidence quality evaluation.Results:We have identified a total of 24 eligible RCTs with 2082 participants and completed a meta-analysis based on these RCTs.The results of the meta-analysis showed that compared with valsartan,NRT combined with valsartan treatment showed effective curative effect in terms of effective treatment rate(OR=4.72;95%CI,3.67,6.08;P<0.00001),24h urine protein quantification(MD=-0.52;95%CI,-0.59,-0.44;P<0.00001),serum creatinine(Scr)(MD=-10.33;95%CI,-14.00,-6.66;P<0.00001),Systolic blood pressure(SBP)(MD=-11.42;95%CI,-17.67,-5.17;P=0.0003),Diastolic blood pressure(DBP)(MD=-6.28;95%CI,-9.14,-3.42;P<0.0001),Blood urine nitrogen(BUN)(MD=-0.02;95%CI,-0.41,0.37;P=0.93),plasma albumin(ALB)(MD=5.05;95%CI,4.27,5.84;P<0.00001),and adverse reactions(OR=0.93,95%CI,0.54,1.60;P=0.78).No serious adverse events were mentioned in these studies.And based on the results of the systematic review,the GRADE system recommended ranking method was used to evaluate the quality of evidence and the recommendation level.The results showed that the level of evidence was moderate and the recommendation intensity was weak recommendation.Conclusions:NRT combined with valsartan has a significant effect on the treatment of CGN,and the treatment effect is better than valsartan

关 键 词：Nephritis rehabilitation tablet VALSARTAN Chronic glomerulonephritis Randomized controlled trial META-ANALYSIS 

分 类 号：R73[医药卫生—肿瘤]