Antibody and complement levels in patients with hypersplenism associated with cirrhotic portal hypertension and therapeutic principles  

作　　者：Kun Zhang Min Zeng Ye-Juan Li Hong-Fei Wu Jin-Cai Wu Zhen-Sheng Zhang Jin-Fang Zheng Yun-Fu Lv 

机构地区：[1]Department of Geriatric Center,Hainan General Hospital,Haikou 570311,Hainan Province,China [2]Reproductive Medicine Center,Maternal and Child Health Care Hospital of Hainan Province,Haikou 570311,Hainan Province,China [3]Department of General Surgery,Hainan General Hospital,Haikou 570311,Hainan Province,China

出　　处：《World Journal of Clinical Cases》2022年第36期13208-13215,共8页世界临床病例杂志

基　　金：Supported by Hainan Provincial Department of Science and Technology,Qiongke[2020]256。

摘　　要：BACKGROUND Hypersplenism associated with cirrhotic portal hypertension is a common condition often resulting from hepatitis B-related cirrhosis.However,the levels of immunoglobulin(Ig)and complement in patients with hypersplenism associated with cirrhotic portal hypertension remain unclear.This study was undertaken to determine the levels of Ig and complement in these patients,the relationship between these levels and Child-Pugh class and their clinical significance.AIM To investigate the antibody(Ig)and complement levels in patients with hypersplenism associated with cirrhotic portal hypertension and their clinical significance.METHODS Clinical data of 119 patients with hypersplenism associated with cirrhotic portal hypertension were statistically analyzed and compared with those of 128 control patients.RESULTS IgA and IgG levels in patients with hypersplenism were significantly higher than controls(P<0.001).There was no significant difference in IgM between the two groups(P=0.109).C3 and C4 levels in patients with hypersplenism were significantly lower than controls(P<0.001).As liver function decreased,IgA and IgG levels increased(P<0.001),and C3 and C4 levels decreased(P<0.001).CONCLUSION Patients with hypersplenism associated with cirrhotic portal hypertension have significantly higher antibody(IgA and IgG)levels and significantly lower complement(C3 and C4)levels,which are both related to liver damage.Clinically,the administration of anti-hepatitis virus agents and protection of liver function should be strengthened.

关 键 词：Hypersplenism associated with cirrhotic portal hypertension COMPLEMENT Treatment HEPATITIS B-immunoglobulin 

分 类 号：R575.2[医药卫生—消化系统]