INTERLEUKIN-21

作品数：14被引量：48H指数：4
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相关领域：医药卫生更多>>
相关作者：王福生张纪元冯国华邹正升金磊更多>>
相关机构：北京大学解放军第三0二医院泉州市第一医院东南大学更多>>
相关期刊：《Cellular & Molecular Immunology》《Acta Pharmacologica Sinica》《World Journal of Hematology》《World Journal of Gastroenterology》更多>>
相关基金：国家自然科学基金更多>>
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C-X-C chemokine receptor type 5+CD8+T cells as immune regulators in hepatitis Be antigen-positive chronic hepatitis B under interferonalpha treatment
《World Journal of Gastroenterology》2025年第3期73-83,共11页Zhen-Yu Xu Zhong-Shang Dai Guo-Zhong Gong Min Zhang 
Supported by Changsha Science and Technology Program,No.kq2022397;Natural Science Foundation of Hunan Province(Departmental Joint Fund),No.2023JJ60440;Research Program of Health Commission of Hunan Province,No.202303088786;Clinical Medical Research Center for Viral Hepatitis of Hunan Province,No.2023SK4009;the Scientific Research Program of FuRong Laboratory,No.2023SK2108.
BACKGROUND C-X-C chemokine receptor type 5(CXCR5)^(+)CD8^(+)T cells represent a unique immune subset with dual roles,functioning as cytotoxic cells in persistent viral infections while promoting B cell responses.Despi...
关键词：C-X-C chemokine receptor type 5 Programmed death-ligand 1 INTERLEUKIN-21 Pegylated interferon-alpha Chronic hepatitis B 
Review of the potential value of serum interleukin levels as prognostic biomarkers of liver failure被引量：1
《World Journal of Clinical Cases》2024年第27期6045-6056,共12页Yong Lin Geng-Jie Yan Mei-Yan Liu Yin Cao Kan Zhang Na Wang Fu-Li Long De-Wen Mao 
The National Natural Science Foundation of China,No.82260907,No.82260899,and No.82274434.
Liver failure(LF)is prevalent in China and is characterized by complex path-ogenesis,challenging clinical management,poor prognosis,and rising incidence and mortality rates.The immune status is an important factor aff...
关键词：INTERLEUKIN-21 INTERLEUKIN-22 Interleukin-31 Liver failure Biological markers Potential value 
Correlation between thrombopoietin and inflammatory factors,platelet indices,and thrombosis in patients with sepsis:A retrospective study被引量：1
《World Journal of Clinical Cases》2022年第13期4072-4083,共12页Wan-Hua Xu Li-Chan Mo Mao-Hua Shi Hui Rao Xiao-Yong Zhan Mo Yang 
Supported by the Guangdong Province Medical Science and Technology Research Foundation,No.B2014377;the Medical Scientific Research Project of Foshan,No.20190036.
BACKGROUND Thrombopoietin(TPO)is a primary regulator of thrombopoiesis in physiological conditions.TPO,in combination with its specific cytokine receptor c-Mpl,drives platelet production by inducing the proliferation ...
关键词：SEPSIS THROMBOPOIETIN INTERLEUKIN-21 PLATELETS THROMBOSIS 
Association between interleukin-21 gene rs907715 polymorphism and gastric precancerous lesions in a Chinese population被引量：3
《World Journal of Gastrointestinal Oncology》2020年第3期289-300,共12页Xiao-Qin Wang Yang Li Paul D Terry Wen-Jing Kou Yue Zhang Zhao-Zhao Hui Xiao-Han Ren Ming-Xu Wang 
Supported by the Fundamental Research Funds for the Central Universities,No.zdyf2017007;Project of Shaanxi Health and Culture Research Center,No.JKWH2019-Z02
BACKGROUND The single nucleotide polymorphisms of interleukin-21(IL-21)gene were confirmed to be related to various diseases,but no studies have examined the possible role of IL-21 single nucleotide polymorphisms(SNPs...
关键词：Interleukin-21 gene Single nucleotide polymorphisms rs907715 Gastric precancerous lesions Intestinal metaplasia 
Advances in the role of follicular T helper cells in graft versus host diseases
《Liver Research》2017年第2期131-134,共4页Maogen Chen Xiaohong Lin Julie Wang Nancy Olsen Song Guo Zheng 
This work was in part supported by the National Natural Science Foundation of China(81373156,81570587,81401324,81671611);Science and Technology Planning Project of Guangdong Province(2016A020215048,2014A030308005);Guangdong Provincial Key Laboratory of Organ Donation and Transplant Immunology(2013A061401007);Guangdong Provincial International Cooperation Base of Science and Technology(Organ Transplantation)(2015B050501002),China.
Graft versus host disease(GVHD)is a refractory complication of allogeneic hematopoietic stem cell transplantation for the treatment of malignant and non-malignant hematopoietic diseases.Inflammatory cascade responses ...
关键词：Graft versus host disease(GVHD) Allogeneic hematopoietic stem cell transplantation INTERLEUKIN-21 Follicular T helper(Tfh)cell 
Prednisone treatment inhibits the differentiation of B Iymphocytes into plasma cells in MRL/MpSlac-lpr mice被引量：4
《Acta Pharmacologica Sinica》2015年第11期1367-1376,共10页Shang-xue YAN Xiao-mei DENG Qing-tong WANG Xiao-jing SUN Wei WEI 
Acknowledgements This work was financially supported by the National Natural Science Foundation of China （No 81173075, 81330081, and 81202541） and the Natural Science Foundation of Anhui Prov- ince （No KJ2011A177）.
Aim： A number of evidence shows that the differentiation of B lymphocytes into plasma cells plays an important role in lupus pathogenesis. In this study we investigated how prednisone, a classical therapeutic drug fo...
关键词：upus erythematosus MRL/Ipr mice PREDNISONE plasma cell differentiation INTERLEUKIN-21 interleukin-10 BLIMP-1 Bcl-6 
Interleukin-21 gene polymorphisms and chronic hepatitis B infection in a Chinese population被引量：7
《World Journal of Gastroenterology》2015年第14期4232-4239,共8页Jia-Yan Yao Kang Chao Min-Rui Li Yan-Qing Wu Bi-Hui Zhong 
Supported by National Natural Science Foundation of China,No.81170392
AIM: To investigate the relationship between inter-leukin-21(IL21) gene polymorphisms and chronic hepatitis B virus(HBV) infection in a Chinese population.METHODS: In this case-control study, 366 Chinese HBV-infected ...
关键词：Chinese population CHRONIC HEPATITIS B VIRUS infec 
Role of interleukin-21 in HBV infection： friend or foe？被引量：7
《Cellular & Molecular Immunology》2015年第3期303-308,共6页Yongyin Li 
The authors express their sincere thanks to Drs Xiaoyong Zhang and Chris Kafai Li for their critical comments. This work was supported by the Major Science and Technology Special Project of China （2008ZX10002-004, 2012ZX10002-003 and 2011CB946100） and the National Natural Science Foundation of China （81270025）.
I nterleukin （I L）-21, a cytokine produced by activated CD4＋ T cells, has broad pleiotropic actions that affect the functions of a variety of lymphoid cells. The roles of IL-21 in modulating immunity to infections ...
关键词：hepatitis B virus IMMUNOMODULATORY INTERLEUKIN-21 
Follicular helper T lymphocytes in health and disease
《World Journal of Hematology》2014年第4期118-127,共10页Cecilia Parodi María Noel Badano Nora Galassi Ana Coraglia Patricia Baré Alejandro Malbrán María Marta de Elizalde de Bracco 
Supported by Consejo Nacional de Investigaciones Científicas y Técnicas,CONICET,PIP Nos.0032 and 11220120100619CO
A correct antibody response requires the participation of both B and T lymphocytes and antigen presenting cells. In this review we address the role of follicular helper T lymphocytes(T FH) in this reaction. We shall f...
关键词：FOLLICULAR helper T(TFH)lymphocytes TFH development Chemokine(C-X-C motif)receptor 5 INTERLEUKIN-21 Programmed CELL death-1/Programmed CELL death ligand 1(PDL-1)or PDL-2 Primary IMMUNODEFICIENCIES Autoimmunity Chronic viral INFECTIONS Protozoan INFECTIONS 
酒精性肝病患者血浆白细胞介素-21水平及重组IL-21对LX-2肝星状细胞增殖和活化的影响被引量：1
《实用肝脏病杂志》2014年第1期18-21,共4页郝书理 张纪元 金磊 孙颖 李保森 冯国华 王福生 邹正升 
国家自然科学基金面上项目(81273249)
目的：分析酒精性肝病患者血浆白细胞介素-21（IL-21）水平及重组IL-21体外对LX-2肝星状细胞增殖和活化的影响。方法采用ELISA法检测17例酒精性肝炎、51例酒精性肝硬化患者和20例健康人血浆IL-21水平；体外培养LX-2肝星状细胞，以IL-21...
关键词：酒精性肝病 肝星状细胞 白细胞介素-21 细胞活化 INTERLEUKIN-21 
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