Advances in the role of follicular T helper cells in graft versus host diseases  

作　　者：Maogen Chen Xiaohong Lin Julie Wang Nancy Olsen Song Guo Zheng 

机构地区：[1]Division of Immunology and Rheumatology,Keck School of Medicine at University of Southern California,CA,USA [2]Organ Transplant Center,First Affiliated Hospital of Sun Yat-sen University,Guangzhou,China [3]Guangdong Provincial Key Laboratory of Organ Donation and Transplant Immunology,Guangzhou,China [4]Guangdong Provincial International Cooperation Base of Science and Technology(Organ Transplantation),Guangzhou,China [5]Center for Clinical Immunology at Sun Yat-sen University,Guangzhou,China [6]Division of General Surgery,The Eastern Hospital of the First Affiliated Hospital of Sun Yat-sen University,Guangzhou,China [7]Division of Rheumatology,Penn State Milton S.Hershey Medical Center,Hershey,PA,USA

出　　处：《Liver Research》2017年第2期131-134,共4页肝脏研究（英文）

基　　金：This work was in part supported by the National Natural Science Foundation of China(81373156,81570587,81401324,81671611);Science and Technology Planning Project of Guangdong Province(2016A020215048,2014A030308005);Guangdong Provincial Key Laboratory of Organ Donation and Transplant Immunology(2013A061401007);Guangdong Provincial International Cooperation Base of Science and Technology(Organ Transplantation)(2015B050501002),China.

摘　　要：Graft versus host disease(GVHD)is a refractory complication of allogeneic hematopoietic stem cell transplantation for the treatment of malignant and non-malignant hematopoietic diseases.Inflammatory cascade responses and cellular immune reactions are the major factors underlying GVHD pathogenesis.Cells producing the cytokine,interleukin(IL)-21 are crucial players involved in injured tissues in GVHD patients.Besides T helper 17 cells,follicular T helper(Tfh)cells are a new source of IL-21 and play a vital role in GVHD pathogenesis.Tfh cell function is mostly regulated by T-follicular regulatory(Tfr)cells that are also located in the germinal center.This review highlights recent advances in the role of Tfh and Tfr cell function in GVHD pathogenesis.New insights are provided into the potential for clinical application in GVHD prevention and treatment.

关 键 词：Graft versus host disease(GVHD) Allogeneic hematopoietic stem cell transplantation INTERLEUKIN-21 Follicular T helper(Tfh)cell 

分 类 号：R73[医药卫生—肿瘤]